The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease

Autores
Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Crohn?s disease is an idiopathic disorder of the gut thought to be caused by a combination
of environmental and genetic factors in susceptible individuals. It is characterized by
chronic transmural inflammation of the terminal ileum and colon, with typical transmural
lesions. Complications, including fibrosis, mean that between 40 and 70% of patients
require surgery in the first 10 years after diagnosis. Presently, there is no evidence that
the current therapies which dampen inflammation modulate or reverse intestinal fibrosis.
In this review, we focus on cytokines that may lead to fibrosis and stenosis and the
contribution of experimental models for understanding and treatment of gut fibrosis.
Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Queen Mary University of London; Reino Unido
Fil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: MacDonald, Thomas T.. Queen Mary University of London; Reino Unido
Materia
CROHN´S DISEASE
FIBROSIS
FIBROSTENOSIS
CYTOKINES
STRICTURES
EXTRACELLULAR MATRIX
CHRONIC INFLAMATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/48715
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The Role of Cytokines in the Fibrotic Responses in Crohn’s DiseaseCurciarello, RenataDocena, Guillermo H.MacDonald, Thomas T.CROHN´S DISEASEFIBROSISFIBROSTENOSISCYTOKINESSTRICTURESEXTRACELLULAR MATRIXCHRONIC INFLAMATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Crohn?s disease is an idiopathic disorder of the gut thought to be caused by a combination<br />of environmental and genetic factors in susceptible individuals. It is characterized by<br />chronic transmural inflammation of the terminal ileum and colon, with typical transmural<br />lesions. Complications, including fibrosis, mean that between 40 and 70% of patients<br />require surgery in the first 10 years after diagnosis. Presently, there is no evidence that<br />the current therapies which dampen inflammation modulate or reverse intestinal fibrosis.<br />In this review, we focus on cytokines that may lead to fibrosis and stenosis and the<br />contribution of experimental models for understanding and treatment of gut fibrosis.Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Queen Mary University of London; Reino UnidoFil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; ArgentinaFil: MacDonald, Thomas T.. Queen Mary University of London; Reino UnidoFrontiers Research Foundation2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/48715Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.; The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease; Frontiers Research Foundation; Frontiers in Medicine; 4; 8-20172296-858XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2017.00126/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2017.00126info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:36:47Zoai:ri.conicet.gov.ar:11336/48715instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:36:47.336CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
title The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
spellingShingle The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
Curciarello, Renata
CROHN´S DISEASE
FIBROSIS
FIBROSTENOSIS
CYTOKINES
STRICTURES
EXTRACELLULAR MATRIX
CHRONIC INFLAMATION
title_short The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
title_full The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
title_fullStr The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
title_full_unstemmed The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
title_sort The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease
dc.creator.none.fl_str_mv Curciarello, Renata
Docena, Guillermo H.
MacDonald, Thomas T.
author Curciarello, Renata
author_facet Curciarello, Renata
Docena, Guillermo H.
MacDonald, Thomas T.
author_role author
author2 Docena, Guillermo H.
MacDonald, Thomas T.
author2_role author
author
dc.subject.none.fl_str_mv CROHN´S DISEASE
FIBROSIS
FIBROSTENOSIS
CYTOKINES
STRICTURES
EXTRACELLULAR MATRIX
CHRONIC INFLAMATION
topic CROHN´S DISEASE
FIBROSIS
FIBROSTENOSIS
CYTOKINES
STRICTURES
EXTRACELLULAR MATRIX
CHRONIC INFLAMATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Crohn?s disease is an idiopathic disorder of the gut thought to be caused by a combination<br />of environmental and genetic factors in susceptible individuals. It is characterized by<br />chronic transmural inflammation of the terminal ileum and colon, with typical transmural<br />lesions. Complications, including fibrosis, mean that between 40 and 70% of patients<br />require surgery in the first 10 years after diagnosis. Presently, there is no evidence that<br />the current therapies which dampen inflammation modulate or reverse intestinal fibrosis.<br />In this review, we focus on cytokines that may lead to fibrosis and stenosis and the<br />contribution of experimental models for understanding and treatment of gut fibrosis.
Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina. Queen Mary University of London; Reino Unido
Fil: Docena, Guillermo H.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Estudios Inmunológicos y Fisiopatológicos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Estudios Inmunológicos y Fisiopatológicos; Argentina
Fil: MacDonald, Thomas T.. Queen Mary University of London; Reino Unido
description Crohn?s disease is an idiopathic disorder of the gut thought to be caused by a combination<br />of environmental and genetic factors in susceptible individuals. It is characterized by<br />chronic transmural inflammation of the terminal ileum and colon, with typical transmural<br />lesions. Complications, including fibrosis, mean that between 40 and 70% of patients<br />require surgery in the first 10 years after diagnosis. Presently, there is no evidence that<br />the current therapies which dampen inflammation modulate or reverse intestinal fibrosis.<br />In this review, we focus on cytokines that may lead to fibrosis and stenosis and the<br />contribution of experimental models for understanding and treatment of gut fibrosis.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/48715
Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.; The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease; Frontiers Research Foundation; Frontiers in Medicine; 4; 8-2017
2296-858X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/48715
identifier_str_mv Curciarello, Renata; Docena, Guillermo H.; MacDonald, Thomas T.; The Role of Cytokines in the Fibrotic Responses in Crohn’s Disease; Frontiers Research Foundation; Frontiers in Medicine; 4; 8-2017
2296-858X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmed.2017.00126/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2017.00126
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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