Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
- Autores
- Pérez Vidakovics, María Laura Anabella; Lamberti, Yanina Andrea; Serra, Diego; Berbers, Guy A. M.; Pol, W. Ludo van der; Rodríguez, María Eugenia
- Año de publicación
- 2007
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/83149
Ver los metadatos del registro completo
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Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cellsPérez Vidakovics, María Laura AnabellaLamberti, Yanina AndreaSerra, DiegoBerbers, Guy A. M.Pol, W. Ludo van derRodríguez, María EugeniaCiencias ExactasAttachmentBordetella pertussisIron stressWhooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.Centro de Investigación y Desarrollo en Fermentaciones Industriales2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf414-421http://sedici.unlp.edu.ar/handle/10915/83149enginfo:eu-repo/semantics/altIdentifier/issn/0928-8244info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2007.00320.xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:41Zoai:sedici.unlp.edu.ar:10915/83149Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:42.041SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
title |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
spellingShingle |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells Pérez Vidakovics, María Laura Anabella Ciencias Exactas Attachment Bordetella pertussis Iron stress |
title_short |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
title_full |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
title_fullStr |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
title_full_unstemmed |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
title_sort |
Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells |
dc.creator.none.fl_str_mv |
Pérez Vidakovics, María Laura Anabella Lamberti, Yanina Andrea Serra, Diego Berbers, Guy A. M. Pol, W. Ludo van der Rodríguez, María Eugenia |
author |
Pérez Vidakovics, María Laura Anabella |
author_facet |
Pérez Vidakovics, María Laura Anabella Lamberti, Yanina Andrea Serra, Diego Berbers, Guy A. M. Pol, W. Ludo van der Rodríguez, María Eugenia |
author_role |
author |
author2 |
Lamberti, Yanina Andrea Serra, Diego Berbers, Guy A. M. Pol, W. Ludo van der Rodríguez, María Eugenia |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Attachment Bordetella pertussis Iron stress |
topic |
Ciencias Exactas Attachment Bordetella pertussis Iron stress |
dc.description.none.fl_txt_mv |
Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
description |
Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/83149 |
url |
http://sedici.unlp.edu.ar/handle/10915/83149 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/0928-8244 info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2007.00320.x |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 414-421 |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
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Universidad Nacional de La Plata |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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alira@sedici.unlp.edu.ar |
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