Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells

Autores
Pérez Vidakovics, María Laura Anabella; Lamberti, Yanina Andrea; Serra, Diego; Berbers, Guy A. M.; Pol, W. Ludo van der; Rodríguez, María Eugenia
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/83149
Acceder
id SEDICI_d92f15204ba09868acbc1ea65e0ec3f4
oai_identifier_str oai:sedici.unlp.edu.ar:10915/83149
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cellsPérez Vidakovics, María Laura AnabellaLamberti, Yanina AndreaSerra, DiegoBerbers, Guy A. M.Pol, W. Ludo van derRodríguez, María EugeniaCiencias ExactasAttachmentBordetella pertussisIron stressWhooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.Centro de Investigación y Desarrollo en Fermentaciones Industriales2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf414-421http://sedici.unlp.edu.ar/handle/10915/83149enginfo:eu-repo/semantics/altIdentifier/issn/0928-8244info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2007.00320.xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T16:56:32Zoai:sedici.unlp.edu.ar:10915/83149Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 16:56:32.511SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
spellingShingle Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
Pérez Vidakovics, María Laura Anabella
Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
title_short Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_full Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_fullStr Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_full_unstemmed Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
title_sort Iron stress increases Bordetella pertussis mucin-binding capacity and attachment to respiratory epithelial cells
dc.creator.none.fl_str_mv Pérez Vidakovics, María Laura Anabella
Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
author Pérez Vidakovics, María Laura Anabella
author_facet Pérez Vidakovics, María Laura Anabella
Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
author_role author
author2 Lamberti, Yanina Andrea
Serra, Diego
Berbers, Guy A. M.
Pol, W. Ludo van der
Rodríguez, María Eugenia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
topic Ciencias Exactas
Attachment
Bordetella pertussis
Iron stress
dc.description.none.fl_txt_mv Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description Whooping cough is a reemerging infectious disease of the respiratory tract caused by Bordetella pertussis. The incomplete understanding of the molecular mechanisms of host colonization hampers the efforts to control this disease. Among the environmental factors that commonly determine the bacterial phenotype, the concentration of essential nutrients is of particular importance. Iron, a crucial and scarce nutrient in the natural environment of B. pertussis, has been found to induce substantial phenotypic changes in this pathogen. However, the relevance of this phenotype for the interaction with host cells was never investigated. Using an in vitro model for bacterial attachment, it was shown that the attachment capacity of B. pertussis to epithelial respiratory cells is enhanced under iron stress conditions. Attachment is mediated by iron-induced surface-exposed proteins with sialic acid-binding capacity. The results further suggest that some of these iron-induced surface-associated proteins are immunogenic and may represent attractive vaccine candidates.
publishDate 2007
dc.date.none.fl_str_mv 2007
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/83149
url http://sedici.unlp.edu.ar/handle/10915/83149
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0928-8244
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2007.00320.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
414-421
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.982451

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