Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies
- Autores
- Rodríguez, María Eugenia; Hellwig, Sandra M.M.; Pérez Vidakovics, María Laura Anabella; Berbers, Guy A.M.; Van De Winkel, Jan G.J.
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon.
Centro de Investigación y Desarrollo en Fermentaciones Industriales - Materia
-
Biología
Antibody
Bordetella pertussis
Fimbriae
Host protection - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/83112
Ver los metadatos del registro completo
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Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodiesRodríguez, María EugeniaHellwig, Sandra M.M.Pérez Vidakovics, María Laura AnabellaBerbers, Guy A.M.Van De Winkel, Jan G.J.BiologíaAntibodyBordetella pertussisFimbriaeHost protectionBordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon.Centro de Investigación y Desarrollo en Fermentaciones Industriales2006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf39-47http://sedici.unlp.edu.ar/handle/10915/83112enginfo:eu-repo/semantics/altIdentifier/issn/0928-8244info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2005.00001.xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:46Zoai:sedici.unlp.edu.ar:10915/83112Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:46.79SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| title |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| spellingShingle |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies Rodríguez, María Eugenia Biología Antibody Bordetella pertussis Fimbriae Host protection |
| title_short |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| title_full |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| title_fullStr |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| title_full_unstemmed |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| title_sort |
Bordetella pertussis attachment to respiratory epithelial cells can be impaired by fimbriae-specific antibodies |
| dc.creator.none.fl_str_mv |
Rodríguez, María Eugenia Hellwig, Sandra M.M. Pérez Vidakovics, María Laura Anabella Berbers, Guy A.M. Van De Winkel, Jan G.J. |
| author |
Rodríguez, María Eugenia |
| author_facet |
Rodríguez, María Eugenia Hellwig, Sandra M.M. Pérez Vidakovics, María Laura Anabella Berbers, Guy A.M. Van De Winkel, Jan G.J. |
| author_role |
author |
| author2 |
Hellwig, Sandra M.M. Pérez Vidakovics, María Laura Anabella Berbers, Guy A.M. Van De Winkel, Jan G.J. |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Biología Antibody Bordetella pertussis Fimbriae Host protection |
| topic |
Biología Antibody Bordetella pertussis Fimbriae Host protection |
| dc.description.none.fl_txt_mv |
Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon. Centro de Investigación y Desarrollo en Fermentaciones Industriales |
| description |
Bordetella pertussis attachment to host cells is a crucial step in colonization. In this study, we investigated the specificity of antibodies, induced either by vaccination or infection, capable of reducing bacterial adherence to respiratory epithelial cells. Both sera and purified anti-B. pertussis IgG or IgA fractions efficiently reduced attachment. This effect was found to be mediated mainly by fimbriae-specific antibodies. Antibodies with other specificities did not significantly interfere in the interaction of B. pertussis with respiratory epithelial cells, with the exception of antifilamentous hemaglutinin antibodies, which reduced bacterial attachment. However, this effect was smaller in magnitude than that observed in the presence of fimbriae-specific antibodies. The strong agglutinating activity of antifimbriae antibodies seems to be involved in this phenomenon. |
| publishDate |
2006 |
| dc.date.none.fl_str_mv |
2006 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/83112 |
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eng |
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eng |
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info:eu-repo/semantics/altIdentifier/issn/0928-8244 info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1574-695X.2005.00001.x |
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http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
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