Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological med...

Autores
Matesanz, Ana I.; Jimenez Faraco, Eva; Ruiz, María Carolina; Balsa, Lucía Mariana; Navarro Ranninger, Carmen; León, Ignacio Esteban; Quiroga, Adoración G.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
Puede accederse a los datos primarios de este trabajo haciendo clic en "Documentos relacionados".
Facultad de Ciencias Exactas
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/109054
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/109054
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological mediaMatesanz, Ana I.Jimenez Faraco, EvaRuiz, María CarolinaBalsa, Lucía MarianaNavarro Ranninger, CarmenLeón, Ignacio EstebanQuiroga, Adoración G.Ciencias ExactasQuímicamononuclear structuresbiological interactionsPd(II) complexPt(II) complexTwo Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.Puede accederse a los datos primarios de este trabajo haciendo clic en "Documentos relacionados".Facultad de Ciencias ExactasCentro de Química Inorgánica2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf73-83http://sedici.unlp.edu.ar/handle/10915/109054enginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/QI/C7QI00446Jinfo:eu-repo/semantics/altIdentifier/issn/2052-1553info:eu-repo/semantics/altIdentifier/doi/10.1039/C7QI00446Jinfo:eu-repo/semantics/reference/hdl/10915/109060info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:24:42Zoai:sedici.unlp.edu.ar:10915/109054Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:24:43.014SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
spellingShingle Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
Matesanz, Ana I.
Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
title_short Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_fullStr Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full_unstemmed Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_sort Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
dc.creator.none.fl_str_mv Matesanz, Ana I.
Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author Matesanz, Ana I.
author_facet Matesanz, Ana I.
Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author_role author
author2 Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
topic Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
dc.description.none.fl_txt_mv Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
Puede accederse a los datos primarios de este trabajo haciendo clic en "Documentos relacionados".
Facultad de Ciencias Exactas
Centro de Química Inorgánica
description Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/109054
url http://sedici.unlp.edu.ar/handle/10915/109054
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2018/QI/C7QI00446J
info:eu-repo/semantics/altIdentifier/issn/2052-1553
info:eu-repo/semantics/altIdentifier/doi/10.1039/C7QI00446J
info:eu-repo/semantics/reference/hdl/10915/109060
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
73-83
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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