Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from bio...

Autores
Matesanz, Ana I.; Jimenez Faraco, Eva; Ruiz, María Carolina; Balsa, Lucía Mariana; Navarro Ranninger, Carmen; León, Ignacio Esteban; Quiroga, Adoración G.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
conjunto de datos
Estado
versión publicada
Descripción
Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
Fil: Balsa, Lucía Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina.
Fil: León, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino";Argentina
Fil: León, Ignacio Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ruiz, María Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina
Facultad de Ciencias Exactas
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/109060
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/109060
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological mediaMatesanz, Ana I.Jimenez Faraco, EvaRuiz, María CarolinaBalsa, Lucía MarianaNavarro Ranninger, CarmenLeón, Ignacio EstebanQuiroga, Adoración G.Ciencias ExactasQuímicahttps://purl.org/becyt/ford/1.4mononuclear structuresbiological interactionsPd(II) complexPt(II) complexTwo Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.Fil: Balsa, Lucía Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina.Fil: León, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino";ArgentinaFil: León, Ignacio Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Ruiz, María Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; ArgentinaFacultad de Ciencias ExactasCentro de Química Inorgánica2017info:eu-repo/semantics/publishedVersionConjunto de datoshttp://purl.org/coar/resource_type/c_ddb1info:ar-repo/semantics/conjuntoDeDatosinfo:eu-repo/semantics/dataSetapplication/octet-streamData were collected on a Bruker Kappa Apex II diffractometer. The software package SHELXTL was used for space group determination, structure solution, and refinement. The structure was solved by direct methods, completed with difference Fourier syntheses, and refined with anisotropic displacement parameters.http://sedici.unlp.edu.ar/handle/10915/109060https://doi.org/10.35537/10915/109060enginfo:eu-repo/semantics/reference/hdl/10915/109054info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:24:42Zoai:sedici.unlp.edu.ar:10915/109060Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:24:43.035SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
spellingShingle Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
Matesanz, Ana I.
Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
title_short Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_fullStr Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_full_unstemmed Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
title_sort Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
dc.creator.none.fl_str_mv Matesanz, Ana I.
Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author Matesanz, Ana I.
author_facet Matesanz, Ana I.
Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author_role author
author2 Jimenez Faraco, Eva
Ruiz, María Carolina
Balsa, Lucía Mariana
Navarro Ranninger, Carmen
León, Ignacio Esteban
Quiroga, Adoración G.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
topic Ciencias Exactas
Química
mononuclear structures
biological interactions
Pd(II) complex
Pt(II) complex
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
dc.description.none.fl_txt_mv Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
Fil: Balsa, Lucía Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina.
Fil: León, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino";Argentina
Fil: León, Ignacio Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ruiz, María Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina
Facultad de Ciencias Exactas
Centro de Química Inorgánica
description Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
Conjunto de datos
http://purl.org/coar/resource_type/c_ddb1
info:ar-repo/semantics/conjuntoDeDatos
info:eu-repo/semantics/dataSet
status_str publishedVersion
format dataSet
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/109060
https://doi.org/10.35537/10915/109060
url http://sedici.unlp.edu.ar/handle/10915/109060
https://doi.org/10.35537/10915/109060
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/reference/hdl/10915/109054
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/octet-stream
Data were collected on a Bruker Kappa Apex II diffractometer. The software package SHELXTL was used for space group determination, structure solution, and refinement. The structure was solved by direct methods, completed with difference Fourier syntheses, and refined with anisotropic displacement parameters.
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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