A Novel Sulfonamidoglycosylation of Glycals

Autores
Colinas, Pedro Alfonso; Bravo, Rodolfo Daniel
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.
Laboratorio de Estudio de Compuestos Orgánicos
Materia
Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/129282
Acceder
id SEDICI_d3507d7c8f34cfbdd176e52e51ae789e
oai_identifier_str oai:sedici.unlp.edu.ar:10915/129282
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling A Novel Sulfonamidoglycosylation of GlycalsColinas, Pedro AlfonsoBravo, Rodolfo DanielQuímicaAddition reactionsCatalystsInhibitorsSulfonesPharmaceuticalsThe sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.Laboratorio de Estudio de Compuestos Orgánicos2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf4509-4511http://sedici.unlp.edu.ar/handle/10915/129282enginfo:eu-repo/semantics/altIdentifier/issn/1523-7060info:eu-repo/semantics/altIdentifier/issn/1523-7052info:eu-repo/semantics/altIdentifier/doi/10.1021/ol035838ginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-26T10:09:03Zoai:sedici.unlp.edu.ar:10915/129282Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-26 10:09:03.541SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A Novel Sulfonamidoglycosylation of Glycals
title A Novel Sulfonamidoglycosylation of Glycals
spellingShingle A Novel Sulfonamidoglycosylation of Glycals
Colinas, Pedro Alfonso
Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
title_short A Novel Sulfonamidoglycosylation of Glycals
title_full A Novel Sulfonamidoglycosylation of Glycals
title_fullStr A Novel Sulfonamidoglycosylation of Glycals
title_full_unstemmed A Novel Sulfonamidoglycosylation of Glycals
title_sort A Novel Sulfonamidoglycosylation of Glycals
dc.creator.none.fl_str_mv Colinas, Pedro Alfonso
Bravo, Rodolfo Daniel
author Colinas, Pedro Alfonso
author_facet Colinas, Pedro Alfonso
Bravo, Rodolfo Daniel
author_role author
author2 Bravo, Rodolfo Daniel
author2_role author
dc.subject.none.fl_str_mv Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
topic Química
Addition reactions
Catalysts
Inhibitors
Sulfones
Pharmaceuticals
dc.description.none.fl_txt_mv The sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.
Laboratorio de Estudio de Compuestos Orgánicos
description The sulfonamidoglycosylation of benzylated glycals using a catalytic amount of triphenylphosphine hydrobromide proceeded in a highly stereoselective fashion to give the β anomers with good to high yields. This process was demonstrated with D-galactal and D-glucal. Two of the new N-2-(deoxyglycosyl)sulfonamides were tested as inhibitors of tumor cell growth in vitro and showed antiproliferative properties in the micromolar range.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/129282
url http://sedici.unlp.edu.ar/handle/10915/129282
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1523-7060
info:eu-repo/semantics/altIdentifier/issn/1523-7052
info:eu-repo/semantics/altIdentifier/doi/10.1021/ol035838g
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
4509-4511
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.011256

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