Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology
- Autores
- Bouzat, Cecilia
- Año de publicación
- 2005
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Ligand binding and channel gating are dynamic processes that require precise and coordinated movements of the protein, which have recently begun to be unraveled. Desensitization still remains a complex and mysterious process. If the goal of designing new ligands targeted to specific LGICs subtypes or to mutated receptors at the origin of the disease states is to be fulfilled, we require an intimate knowledge of the structure-function relationship of them. There is hope that the new understanding of the molecular pharmacology of Cys-loop receptors will led to a new generation of more selective drugs with improved safety profiles.
Sociedad Argentina de Fisiología - Materia
-
Ciencias Médicas
Fisiología
Chemical synapses
Pentameric neurotransmitter-gated ion channels - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/146972
Ver los metadatos del registro completo
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Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathologyBouzat, CeciliaCiencias MédicasFisiologíaChemical synapsesPentameric neurotransmitter-gated ion channelsLigand binding and channel gating are dynamic processes that require precise and coordinated movements of the protein, which have recently begun to be unraveled. Desensitization still remains a complex and mysterious process. If the goal of designing new ligands targeted to specific LGICs subtypes or to mutated receptors at the origin of the disease states is to be fulfilled, we require an intimate knowledge of the structure-function relationship of them. There is hope that the new understanding of the molecular pharmacology of Cys-loop receptors will led to a new generation of more selective drugs with improved safety profiles.Sociedad Argentina de Fisiología2005-12info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/146972enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol1_n5_december_1_.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:29:22Zoai:sedici.unlp.edu.ar:10915/146972Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:29:22.755SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| title |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| spellingShingle |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology Bouzat, Cecilia Ciencias Médicas Fisiología Chemical synapses Pentameric neurotransmitter-gated ion channels |
| title_short |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| title_full |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| title_fullStr |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| title_full_unstemmed |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| title_sort |
Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology |
| dc.creator.none.fl_str_mv |
Bouzat, Cecilia |
| author |
Bouzat, Cecilia |
| author_facet |
Bouzat, Cecilia |
| author_role |
author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas Fisiología Chemical synapses Pentameric neurotransmitter-gated ion channels |
| topic |
Ciencias Médicas Fisiología Chemical synapses Pentameric neurotransmitter-gated ion channels |
| dc.description.none.fl_txt_mv |
Ligand binding and channel gating are dynamic processes that require precise and coordinated movements of the protein, which have recently begun to be unraveled. Desensitization still remains a complex and mysterious process. If the goal of designing new ligands targeted to specific LGICs subtypes or to mutated receptors at the origin of the disease states is to be fulfilled, we require an intimate knowledge of the structure-function relationship of them. There is hope that the new understanding of the molecular pharmacology of Cys-loop receptors will led to a new generation of more selective drugs with improved safety profiles. Sociedad Argentina de Fisiología |
| description |
Ligand binding and channel gating are dynamic processes that require precise and coordinated movements of the protein, which have recently begun to be unraveled. Desensitization still remains a complex and mysterious process. If the goal of designing new ligands targeted to specific LGICs subtypes or to mutated receptors at the origin of the disease states is to be fulfilled, we require an intimate knowledge of the structure-function relationship of them. There is hope that the new understanding of the molecular pharmacology of Cys-loop receptors will led to a new generation of more selective drugs with improved safety profiles. |
| publishDate |
2005 |
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2005-12 |
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info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/146972 |
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eng |
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eng |
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