The Influence of MicroRNAs on Mitochondrial Calcium

Autores
Jaquenod De Giusti, Carolina; Román, Bárbara Soledad; Das, Samarjit
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abnormal mitochondrial calcium ([Ca2+]m) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca2+]m uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca2+]m levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca2+]m handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca2+]m handling.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
Materia
Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107839
Acceder
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network_name_str SEDICI (UNLP)
spelling The Influence of MicroRNAs on Mitochondrial CalciumJaquenod De Giusti, CarolinaRomán, Bárbara SoledadDas, SamarjitMedicinamicroRNAmiRNAmitochondriaMitomiRmitochondrial calciumheart failureAbnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca<sup>2+</sup>]<sub>m</sub> uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca<sup>2+</sup>]<sub>m</sub> levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca<sup>2+</sup>]<sub>m</sub> handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca<sup>2+</sup>]<sub>m</sub> handling.Facultad de Ciencias MédicasCentro de Investigaciones Cardiovasculares2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/107839enginfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6160583&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2018.01291/fullinfo:eu-repo/semantics/altIdentifier/issn/1664-042Xinfo:eu-repo/semantics/altIdentifier/pmid/30298016info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01291info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:06Zoai:sedici.unlp.edu.ar:10915/107839Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:06.868SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The Influence of MicroRNAs on Mitochondrial Calcium
title The Influence of MicroRNAs on Mitochondrial Calcium
spellingShingle The Influence of MicroRNAs on Mitochondrial Calcium
Jaquenod De Giusti, Carolina
Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
title_short The Influence of MicroRNAs on Mitochondrial Calcium
title_full The Influence of MicroRNAs on Mitochondrial Calcium
title_fullStr The Influence of MicroRNAs on Mitochondrial Calcium
title_full_unstemmed The Influence of MicroRNAs on Mitochondrial Calcium
title_sort The Influence of MicroRNAs on Mitochondrial Calcium
dc.creator.none.fl_str_mv Jaquenod De Giusti, Carolina
Román, Bárbara Soledad
Das, Samarjit
author Jaquenod De Giusti, Carolina
author_facet Jaquenod De Giusti, Carolina
Román, Bárbara Soledad
Das, Samarjit
author_role author
author2 Román, Bárbara Soledad
Das, Samarjit
author2_role author
author
dc.subject.none.fl_str_mv Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
topic Medicina
microRNA
miRNA
mitochondria
MitomiR
mitochondrial calcium
heart failure
dc.description.none.fl_txt_mv Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca<sup>2+</sup>]<sub>m</sub> uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca<sup>2+</sup>]<sub>m</sub> levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca<sup>2+</sup>]<sub>m</sub> handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca<sup>2+</sup>]<sub>m</sub> handling.
Facultad de Ciencias Médicas
Centro de Investigaciones Cardiovasculares
description Abnormal mitochondrial calcium ([Ca<sup>2+</sup>]<sub>m</sub>) handling and energy deficiency results in cellular dysfunction and cell death. Recent studies suggest that nuclear-encoded microRNAs (miRNA) are able to translocate in to the mitochondrial compartment, and modulate mitochondrial activities, including [Ca<sup>2+</sup>]<sub>m</sub> uptake. Apart from this subset of miRNAs, there are several miRNAs that have been reported to target genes that play a role in maintaining [Ca<sup>2+</sup>]<sub>m</sub> levels in the cytoplasm. It is imperative to validate miRNAs that alter [Ca<sup>2+</sup>]<sub>m</sub> handling, and thereby alter cellular fate. The focus of this review is to highlight the mitochondrial miRNAs (MitomiRs), and other cytosolic miRNAs that target mRNAs which play an important role in [Ca<sup>2+</sup>]<sub>m</sub> handling.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/107839
url http://sedici.unlp.edu.ar/handle/10915/107839
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6160583&blobtype=pdf
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphys.2018.01291/full
info:eu-repo/semantics/altIdentifier/issn/1664-042X
info:eu-repo/semantics/altIdentifier/pmid/30298016
info:eu-repo/semantics/altIdentifier/doi/10.3389/fphys.2018.01291
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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