A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents
- Autores
- Díaz, Jorge R. A.; Fernández Baldo, Martín Alejandro; Echeverría, Gustavo Alberto; Baldoni, Héctor Armando; Vullo, Daniela; Soria, Delia Beatriz; Supuran, Claudiu T.; Camí, Gerardo Enrique
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, 1H, and 13C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P21/c space group. Antifungal activity was screened against eight pathogenic yeasts: Candida albicans (DMic 972576), Candida krusei (DMic 951705), Candida glabrata (DMic 982882), Candida tropicalis (DMic 982884), Candida dubliniensis (DMic 93695), Candida guilliermondii (DMic 021150), Cryptococcus neoformans (ATCC 24067), and Cryptococcus gattii (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.
Facultad de Ciencias Exactas
Instituto de Física La Plata
Centro de Química Inorgánica - Materia
-
Ciencias Exactas
Física
Química
antifungal
carbonic anhydrase
metal complex
sulfonamide
thermal stability - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/103239
Ver los metadatos del registro completo
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A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agentsDíaz, Jorge R. A.Fernández Baldo, Martín AlejandroEcheverría, Gustavo AlbertoBaldoni, Héctor ArmandoVullo, DanielaSoria, Delia BeatrizSupuran, Claudiu T.Camí, Gerardo EnriqueCiencias ExactasFísicaQuímicaantifungalcarbonic anhydrasemetal complexsulfonamidethermal stabilityA sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P2<sub>1</sub>/c space group. Antifungal activity was screened against eight pathogenic yeasts: <i>Candida albicans</i> (DMic 972576), <i>Candida krusei</i> (DMic 951705), <i>Candida glabrata</i> (DMic 982882), <i>Candida tropicalis</i> (DMic 982884), <i>Candida dubliniensis</i> (DMic 93695), <i>Candida guilliermondii</i> (DMic 021150), <i>Cryptococcus neoformans</i> (ATCC 24067), and <i>Cryptococcus gattii</i> (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported.Facultad de Ciencias ExactasInstituto de Física La PlataCentro de Química Inorgánica2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf51-62http://sedici.unlp.edu.ar/handle/10915/103239enginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/14756366.2016.1187143info:eu-repo/semantics/altIdentifier/issn/1475-6374info:eu-repo/semantics/altIdentifier/doi/10.1080/14756366.2016.1187143info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:14:19Zoai:sedici.unlp.edu.ar:10915/103239Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:14:19.855SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| title |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| spellingShingle |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents Díaz, Jorge R. A. Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability |
| title_short |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| title_full |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| title_fullStr |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| title_full_unstemmed |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| title_sort |
A substituted sulfonamide and its Co (II), Cu (II), and Zn (II) complexes as potential antifungal agents |
| dc.creator.none.fl_str_mv |
Díaz, Jorge R. A. Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique |
| author |
Díaz, Jorge R. A. |
| author_facet |
Díaz, Jorge R. A. Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique |
| author_role |
author |
| author2 |
Fernández Baldo, Martín Alejandro Echeverría, Gustavo Alberto Baldoni, Héctor Armando Vullo, Daniela Soria, Delia Beatriz Supuran, Claudiu T. Camí, Gerardo Enrique |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability |
| topic |
Ciencias Exactas Física Química antifungal carbonic anhydrase metal complex sulfonamide thermal stability |
| dc.description.none.fl_txt_mv |
A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P2<sub>1</sub>/c space group. Antifungal activity was screened against eight pathogenic yeasts: <i>Candida albicans</i> (DMic 972576), <i>Candida krusei</i> (DMic 951705), <i>Candida glabrata</i> (DMic 982882), <i>Candida tropicalis</i> (DMic 982884), <i>Candida dubliniensis</i> (DMic 93695), <i>Candida guilliermondii</i> (DMic 021150), <i>Cryptococcus neoformans</i> (ATCC 24067), and <i>Cryptococcus gattii</i> (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported. Facultad de Ciencias Exactas Instituto de Física La Plata Centro de Química Inorgánica |
| description |
A sulfonamide 1-tosyl-1-H-benzo(d)imidazol-2-amine (TBZA) and three new complexes of Co(II), Cu(II), and Zn(II) have been synthesized. The compounds have been characterized by elemental analyses, FTIR, <sup>1</sup>H, and <sup>13</sup>C-NMR spectroscopy. The structure of the TBZA, and its Co(II) and Cu(II) complexes, was determined by X-ray diffraction methods. TBZA and its Co(II) complex crystallize in the triclinic P-1 space group, while the Cu(II) complex crystallizes in the monoclinic P2<sub>1</sub>/c space group. Antifungal activity was screened against eight pathogenic yeasts: <i>Candida albicans</i> (DMic 972576), <i>Candida krusei</i> (DMic 951705), <i>Candida glabrata</i> (DMic 982882), <i>Candida tropicalis</i> (DMic 982884), <i>Candida dubliniensis</i> (DMic 93695), <i>Candida guilliermondii</i> (DMic 021150), <i>Cryptococcus neoformans</i> (ATCC 24067), and <i>Cryptococcus gattii</i> (ATCC MYA-4561). Results on the inhibition of various human (h) CAs, hCA I, II, IV, VII, IX, and XII, and pathogenic beta and gamma CAs are also reported. |
| publishDate |
2016 |
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2016 |
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eng |
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eng |
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