Antiseizure medication discovery: Recent and future paradigm shifts
- Autores
- Talevi, Alan
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100 years. How efficient are we translating positive outcomes from basic research to clinical trials and/or the clinical scenario? It is possible that fresh thinking and exploration of new paradigms are required to arrive at truly novel therapeutic solutions, as seemingly proven by recently approved first-in-class antiseizure medications and drug candidates undergoing late clinical trials. Here, the author discusses some approximations in line with the network pharmacology philosophy, which may result in highly innovative (and, hopefully, safer and/or more efficacious) medications for the control of seizures, as embodied with some recent examples in the field, namely tailored multi-target agents and low-affinity ligands.
Laboratorio de Investigación y Desarrollo de Bioactivos - Materia
-
Ciencias Exactas
Biología
disrupting innovation
drug discovery
epilepsy
innovation
low-affinity ligand
multi-target
multi-target drugs
network pharmacology
partial agonist
radical innovation
systems pharmacology - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/155997
Ver los metadatos del registro completo
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Antiseizure medication discovery: Recent and future paradigm shiftsTalevi, AlanCiencias ExactasBiologíadisrupting innovationdrug discoveryepilepsyinnovationlow-affinity ligandmulti-targetmulti-target drugsnetwork pharmacologypartial agonistradical innovationsystems pharmacologyDespite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100 years. How efficient are we translating positive outcomes from basic research to clinical trials and/or the clinical scenario? It is possible that fresh thinking and exploration of new paradigms are required to arrive at truly novel therapeutic solutions, as seemingly proven by recently approved first-in-class antiseizure medications and drug candidates undergoing late clinical trials. Here, the author discusses some approximations in line with the network pharmacology philosophy, which may result in highly innovative (and, hopefully, safer and/or more efficacious) medications for the control of seizures, as embodied with some recent examples in the field, namely tailored multi-target agents and low-affinity ligands.Laboratorio de Investigación y Desarrollo de Bioactivos2022-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfS133-S141http://sedici.unlp.edu.ar/handle/10915/155997enginfo:eu-repo/semantics/altIdentifier/issn/2470-9239info:eu-repo/semantics/altIdentifier/doi/10.1002/epi4.12581info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:40:31Zoai:sedici.unlp.edu.ar:10915/155997Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:40:32.077SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Antiseizure medication discovery: Recent and future paradigm shifts |
title |
Antiseizure medication discovery: Recent and future paradigm shifts |
spellingShingle |
Antiseizure medication discovery: Recent and future paradigm shifts Talevi, Alan Ciencias Exactas Biología disrupting innovation drug discovery epilepsy innovation low-affinity ligand multi-target multi-target drugs network pharmacology partial agonist radical innovation systems pharmacology |
title_short |
Antiseizure medication discovery: Recent and future paradigm shifts |
title_full |
Antiseizure medication discovery: Recent and future paradigm shifts |
title_fullStr |
Antiseizure medication discovery: Recent and future paradigm shifts |
title_full_unstemmed |
Antiseizure medication discovery: Recent and future paradigm shifts |
title_sort |
Antiseizure medication discovery: Recent and future paradigm shifts |
dc.creator.none.fl_str_mv |
Talevi, Alan |
author |
Talevi, Alan |
author_facet |
Talevi, Alan |
author_role |
author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Biología disrupting innovation drug discovery epilepsy innovation low-affinity ligand multi-target multi-target drugs network pharmacology partial agonist radical innovation systems pharmacology |
topic |
Ciencias Exactas Biología disrupting innovation drug discovery epilepsy innovation low-affinity ligand multi-target multi-target drugs network pharmacology partial agonist radical innovation systems pharmacology |
dc.description.none.fl_txt_mv |
Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100 years. How efficient are we translating positive outcomes from basic research to clinical trials and/or the clinical scenario? It is possible that fresh thinking and exploration of new paradigms are required to arrive at truly novel therapeutic solutions, as seemingly proven by recently approved first-in-class antiseizure medications and drug candidates undergoing late clinical trials. Here, the author discusses some approximations in line with the network pharmacology philosophy, which may result in highly innovative (and, hopefully, safer and/or more efficacious) medications for the control of seizures, as embodied with some recent examples in the field, namely tailored multi-target agents and low-affinity ligands. Laboratorio de Investigación y Desarrollo de Bioactivos |
description |
Despite the ever-increasing number of available options for the treatment of epilepsies and the remarkable advances on the understanding of their pathophysiology, the proportion of refractory patients has remained approximately unmodified during the last 100 years. How efficient are we translating positive outcomes from basic research to clinical trials and/or the clinical scenario? It is possible that fresh thinking and exploration of new paradigms are required to arrive at truly novel therapeutic solutions, as seemingly proven by recently approved first-in-class antiseizure medications and drug candidates undergoing late clinical trials. Here, the author discusses some approximations in line with the network pharmacology philosophy, which may result in highly innovative (and, hopefully, safer and/or more efficacious) medications for the control of seizures, as embodied with some recent examples in the field, namely tailored multi-target agents and low-affinity ligands. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/155997 |
url |
http://sedici.unlp.edu.ar/handle/10915/155997 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/2470-9239 info:eu-repo/semantics/altIdentifier/doi/10.1002/epi4.12581 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
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openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) |
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application/pdf S133-S141 |
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