Synthesis and anticonvulsant activity of amino acid-derived sulfamides

Autores
Gavernet, Luciana; Elvira, Juan E.; Samaja, Gisela; Pastore, Valentina; Sella Cravero, Mariana; Enrique, Andrea Verónica; Estiú, Guillermina; Bruno Blanch, Luis Enrique
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
Facultad de Ciencias Exactas
Materia
Química
Sulfamides
Anticonvulsant compounds
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123431
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Synthesis and anticonvulsant activity of amino acid-derived sulfamidesGavernet, LucianaElvira, Juan E.Samaja, GiselaPastore, ValentinaSella Cravero, MarianaEnrique, Andrea VerónicaEstiú, GuillerminaBruno Blanch, Luis EnriqueQuímicaSulfamidesAnticonvulsant compoundsSulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).Facultad de Ciencias Exactas2009info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1592-1601http://sedici.unlp.edu.ar/handle/10915/123431enginfo:eu-repo/semantics/altIdentifier/issn/1520-4804info:eu-repo/semantics/altIdentifier/issn/0022-2623info:eu-repo/semantics/altIdentifier/pmid/19249853info:eu-repo/semantics/altIdentifier/doi/10.1021/jm800764pinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:28Zoai:sedici.unlp.edu.ar:10915/123431Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:28.799SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title Synthesis and anticonvulsant activity of amino acid-derived sulfamides
spellingShingle Synthesis and anticonvulsant activity of amino acid-derived sulfamides
Gavernet, Luciana
Química
Sulfamides
Anticonvulsant compounds
title_short Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_full Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_fullStr Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_full_unstemmed Synthesis and anticonvulsant activity of amino acid-derived sulfamides
title_sort Synthesis and anticonvulsant activity of amino acid-derived sulfamides
dc.creator.none.fl_str_mv Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
author Gavernet, Luciana
author_facet Gavernet, Luciana
Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
author_role author
author2 Elvira, Juan E.
Samaja, Gisela
Pastore, Valentina
Sella Cravero, Mariana
Enrique, Andrea Verónica
Estiú, Guillermina
Bruno Blanch, Luis Enrique
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
Sulfamides
Anticonvulsant compounds
topic Química
Sulfamides
Anticonvulsant compounds
dc.description.none.fl_txt_mv Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
Facultad de Ciencias Exactas
description Sulfamides are promising functions for the design of new antiepileptic drugs (Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123431
url http://sedici.unlp.edu.ar/handle/10915/123431
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1520-4804
info:eu-repo/semantics/altIdentifier/issn/0022-2623
info:eu-repo/semantics/altIdentifier/pmid/19249853
info:eu-repo/semantics/altIdentifier/doi/10.1021/jm800764p
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1592-1601
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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