Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls

Autores
Fernández, María Elena; Goszczynski, Daniel Estanislao; Prando, Alberto José; Peral García, Pilar; Baldo, Andrés; Giovambattista, Guillermo; Lirón, Juan Pedro
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.
Instituto de Genética Veterinaria
Materia
Ciencias Veterinarias
Bovine
Puberty
Polymorphism
Thyroglobulin
Association study
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/100592
Acceder
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network_name_str SEDICI (UNLP)
spelling Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bullsFernández, María ElenaGoszczynski, Daniel EstanislaoPrando, Alberto JoséPeral García, PilarBaldo, AndrésGiovambattista, GuillermoLirón, Juan PedroCiencias VeterinariasBovinePubertyPolymorphismThyroglobulinAssociation studyPuberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.Instituto de Genética Veterinaria2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf17-20http://sedici.unlp.edu.ar/handle/10915/100592enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/11791info:eu-repo/semantics/altIdentifier/url/http://janimscitechnol.biomedcentral.com/articles/10.1186/2055-0391-56-17info:eu-repo/semantics/altIdentifier/issn/2055-0391info:eu-repo/semantics/altIdentifier/doi/10.1186/2055-0391-56-17info:eu-repo/semantics/altIdentifier/hdl/11336/11791info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:52:07Zoai:sedici.unlp.edu.ar:10915/100592Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:52:07.281SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
title Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
spellingShingle Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
Fernández, María Elena
Ciencias Veterinarias
Bovine
Puberty
Polymorphism
Thyroglobulin
Association study
title_short Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
title_full Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
title_fullStr Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
title_full_unstemmed Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
title_sort Assessing the association of single nucleotide polymorphisms in thyroglobulin gene with age of puberty in bulls
dc.creator.none.fl_str_mv Fernández, María Elena
Goszczynski, Daniel Estanislao
Prando, Alberto José
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
Lirón, Juan Pedro
author Fernández, María Elena
author_facet Fernández, María Elena
Goszczynski, Daniel Estanislao
Prando, Alberto José
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
Lirón, Juan Pedro
author_role author
author2 Goszczynski, Daniel Estanislao
Prando, Alberto José
Peral García, Pilar
Baldo, Andrés
Giovambattista, Guillermo
Lirón, Juan Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Bovine
Puberty
Polymorphism
Thyroglobulin
Association study
topic Ciencias Veterinarias
Bovine
Puberty
Polymorphism
Thyroglobulin
Association study
dc.description.none.fl_txt_mv Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.
Instituto de Genética Veterinaria
description Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development and spermatogenic function. The objective of this study was to evaluate the association between single nucleotide polymorphisms (SNPs) located in thyroglobulin(TG) gene with age of puberty in Angus bulls. Four SNPs were genotyped in 273 animals using SEQUENOM technology and the association between markers and puberty age was analyzed. Results showed a significant association (P < 0.05) between these markers and puberty age estimated at a sperm concentration of 50 million and a progressive motility of 10%. This is the first report of an association of TG polymorphisms with age of puberty in bulls, and results suggest the importance of thyroidal regulation in bovine sexual development and arrival to puberty.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/100592
url http://sedici.unlp.edu.ar/handle/10915/100592
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/11791
info:eu-repo/semantics/altIdentifier/url/http://janimscitechnol.biomedcentral.com/articles/10.1186/2055-0391-56-17
info:eu-repo/semantics/altIdentifier/issn/2055-0391
info:eu-repo/semantics/altIdentifier/doi/10.1186/2055-0391-56-17
info:eu-repo/semantics/altIdentifier/hdl/11336/11791
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
17-20
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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