Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture

Autores
Rivadeneira, Josefina; Barrio, Daniel Alejandro; Etcheverry, Susana Beatriz; Baran, Enrique José
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The oxovanadium(IV) complex of oxodiacetic acid (H₂oda) of stoichiometry [VO(oda)(H₂O)₂], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman, electronic, and electron paramagnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. The effect of the complex in cell differentiation was tested through the specific activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. What occurs with other vanadium compounds [VO(oda)(H₂O)₂] is an inhibitory agent of osteoblast differentiation.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
Oxovanadium(IV)
Oxodiacetic acid
Vibrational spectra
Electronic spectra
EPR spectra
Osteoblasts
Cells in culture
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/133469
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/133469
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in CultureRivadeneira, JosefinaBarrio, Daniel AlejandroEtcheverry, Susana BeatrizBaran, Enrique JoséCiencias ExactasQuímicaOxovanadium(IV)Oxodiacetic acidVibrational spectraElectronic spectraEPR spectraOsteoblastsCells in cultureThe oxovanadium(IV) complex of oxodiacetic acid (H₂oda) of stoichiometry [VO(oda)(H₂O)₂], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman, electronic, and electron paramagnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. The effect of the complex in cell differentiation was tested through the specific activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. What occurs with other vanadium compounds [VO(oda)(H₂O)₂] is an inhibitory agent of osteoblast differentiation.Facultad de Ciencias ExactasCentro de Química Inorgánica2007-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf159-166http://sedici.unlp.edu.ar/handle/10915/133469enginfo:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/altIdentifier/issn/1559-0720info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-007-0025-9info:eu-repo/semantics/altIdentifier/pmid/17873358info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:12:47Zoai:sedici.unlp.edu.ar:10915/133469Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:12:47.626SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
title Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
spellingShingle Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
Rivadeneira, Josefina
Ciencias Exactas
Química
Oxovanadium(IV)
Oxodiacetic acid
Vibrational spectra
Electronic spectra
EPR spectra
Osteoblasts
Cells in culture
title_short Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
title_full Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
title_fullStr Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
title_full_unstemmed Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
title_sort Spectroscopic Characterization of a VO²⁺ Complex of Oxodiacetic Acid and its Bioactivity on Osteoblast-like Cells in Culture
dc.creator.none.fl_str_mv Rivadeneira, Josefina
Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Baran, Enrique José
author Rivadeneira, Josefina
author_facet Rivadeneira, Josefina
Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Baran, Enrique José
author_role author
author2 Barrio, Daniel Alejandro
Etcheverry, Susana Beatriz
Baran, Enrique José
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Oxovanadium(IV)
Oxodiacetic acid
Vibrational spectra
Electronic spectra
EPR spectra
Osteoblasts
Cells in culture
topic Ciencias Exactas
Química
Oxovanadium(IV)
Oxodiacetic acid
Vibrational spectra
Electronic spectra
EPR spectra
Osteoblasts
Cells in culture
dc.description.none.fl_txt_mv The oxovanadium(IV) complex of oxodiacetic acid (H₂oda) of stoichiometry [VO(oda)(H₂O)₂], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman, electronic, and electron paramagnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. The effect of the complex in cell differentiation was tested through the specific activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. What occurs with other vanadium compounds [VO(oda)(H₂O)₂] is an inhibitory agent of osteoblast differentiation.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
description The oxovanadium(IV) complex of oxodiacetic acid (H₂oda) of stoichiometry [VO(oda)(H₂O)₂], which presents an unprecedented tridentate OOO coordination, was thoroughly characterized by infrared, Raman, electronic, and electron paramagnetic resonance spectroscopies. The biological activity of the complex on the cell proliferation and differentiation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but the cytotoxicity was stronger in the normal (MC3T3E1) than in the tumoral (UMR106) osteoblasts. The effect of the complex in cell differentiation was tested through the specific activity of alkaline phosphatase of the UMR106 cells because they expressed a high activity of this enzyme. What occurs with other vanadium compounds [VO(oda)(H₂O)₂] is an inhibitory agent of osteoblast differentiation.
publishDate 2007
dc.date.none.fl_str_mv 2007-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/133469
url http://sedici.unlp.edu.ar/handle/10915/133469
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0163-4984
info:eu-repo/semantics/altIdentifier/issn/1559-0720
info:eu-repo/semantics/altIdentifier/doi/10.1007/s12011-007-0025-9
info:eu-repo/semantics/altIdentifier/pmid/17873358
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
159-166
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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