Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture

Autores
León, Ignacio Esteban; Etcheverry, Susana Beatriz; Parajón Costa, Beatriz Susana; Baran, Enrique José
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The oxovanadium(IV) complex of oxodiacetic acid (H2ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H2O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H2O can be considered as a good candidate to be further investigated in relation to cancer treatment.
El complejo de oxovanadio(IV) del ácido oxodiacético (H2ODA) y 2,2’-dipiridina (bipy) de estequiometría [VO(ODA)(bipy)]⋅H2O, fue caracterizado detalladamente por espectroscopia infrarroja, Raman y electrónica. La actividad biológica del complejo sobre la proliferación celular fue ensayada sobre células osteoblásticas de fenotipo normal (MC3T3-E1) y tumorales (UMR106) en cultivo. El complejo fue más deletéreo sobre los osteoblastos tumorales que sobre los de fenotipo normal, siendo este efecto más marcado con el aumento de la concentración del mismo. Los resultados de estos estudios biológicos permiten considerar al [VO(ODA)(bipy)]⋅H2O como un buen candidato para futuros estudios en relación a los tratamientos antitumorales.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
Materia
Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/102418
Acceder
id SEDICI_8d7e446abcf427b31d9f447ddfb9a21c
oai_identifier_str oai:sedici.unlp.edu.ar:10915/102418
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in cultureLeón, Ignacio EstebanEtcheverry, Susana BeatrizParajón Costa, Beatriz SusanaBaran, Enrique JoséCiencias ExactasQuímicaOxovanadium(IV)oxodiacetic acid2,2’-bipyridinevibrational spectraelectronic spectraosteoblast cells in cultureantitumoral actionThe oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H<sub>2</sub>O can be considered as a good candidate to be further investigated in relation to cancer treatment.El complejo de oxovanadio(IV) del ácido oxodiacético (H<sub>2</sub>ODA) y 2,2’-dipiridina (bipy) de estequiometría [VO(ODA)(bipy)]⋅H<sub>2</sub>O, fue caracterizado detalladamente por espectroscopia infrarroja, Raman y electrónica. La actividad biológica del complejo sobre la proliferación celular fue ensayada sobre células osteoblásticas de fenotipo normal (MC3T3-E1) y tumorales (UMR106) en cultivo. El complejo fue más deletéreo sobre los osteoblastos tumorales que sobre los de fenotipo normal, siendo este efecto más marcado con el aumento de la concentración del mismo. Los resultados de estos estudios biológicos permiten considerar al [VO(ODA)(bipy)]⋅H<sub>2</sub>O como un buen candidato para futuros estudios en relación a los tratamientos antitumorales.Facultad de Ciencias ExactasCentro de Química Inorgánica2013-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf175-179http://sedici.unlp.edu.ar/handle/10915/102418enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/14478info:eu-repo/semantics/altIdentifier/url/https://www.jmcs.org.mx/index.php/jmcs/article/view/204info:eu-repo/semantics/altIdentifier/issn/1870-249Xinfo:eu-repo/semantics/altIdentifier/hdl/11336/14478info:eu-repo/semantics/altIdentifier/doi/10.29356/jmcs.v57i3.204info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc/4.0/Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-11-12T10:44:11Zoai:sedici.unlp.edu.ar:10915/102418Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-11-12 10:44:11.69SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
spellingShingle Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
León, Ignacio Esteban
Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
title_short Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_full Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_fullStr Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_full_unstemmed Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
title_sort Spectroscopic characterization of an Oxovanadium(IV) complex of Oxodiacetic acid and 2,2’-Bipyridine : Bioactivity on Osteoblast-like cells in culture
dc.creator.none.fl_str_mv León, Ignacio Esteban
Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
author León, Ignacio Esteban
author_facet León, Ignacio Esteban
Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
author_role author
author2 Etcheverry, Susana Beatriz
Parajón Costa, Beatriz Susana
Baran, Enrique José
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
topic Ciencias Exactas
Química
Oxovanadium(IV)
oxodiacetic acid
2,2’-bipyridine
vibrational spectra
electronic spectra
osteoblast cells in culture
antitumoral action
dc.description.none.fl_txt_mv The oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H<sub>2</sub>O can be considered as a good candidate to be further investigated in relation to cancer treatment.
El complejo de oxovanadio(IV) del ácido oxodiacético (H<sub>2</sub>ODA) y 2,2’-dipiridina (bipy) de estequiometría [VO(ODA)(bipy)]⋅H<sub>2</sub>O, fue caracterizado detalladamente por espectroscopia infrarroja, Raman y electrónica. La actividad biológica del complejo sobre la proliferación celular fue ensayada sobre células osteoblásticas de fenotipo normal (MC3T3-E1) y tumorales (UMR106) en cultivo. El complejo fue más deletéreo sobre los osteoblastos tumorales que sobre los de fenotipo normal, siendo este efecto más marcado con el aumento de la concentración del mismo. Los resultados de estos estudios biológicos permiten considerar al [VO(ODA)(bipy)]⋅H<sub>2</sub>O como un buen candidato para futuros estudios en relación a los tratamientos antitumorales.
Facultad de Ciencias Exactas
Centro de Química Inorgánica
description The oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H<sub>2</sub>O can be considered as a good candidate to be further investigated in relation to cancer treatment.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/102418
url http://sedici.unlp.edu.ar/handle/10915/102418
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/14478
info:eu-repo/semantics/altIdentifier/url/https://www.jmcs.org.mx/index.php/jmcs/article/view/204
info:eu-repo/semantics/altIdentifier/issn/1870-249X
info:eu-repo/semantics/altIdentifier/hdl/11336/14478
info:eu-repo/semantics/altIdentifier/doi/10.29356/jmcs.v57i3.204
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc/4.0/
Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
dc.format.none.fl_str_mv application/pdf
175-179
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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