Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study

Autores
Larramendy, Marcelo Luis; Majander, Päivi; Saarto, Tiina; Tenhunen, Mikko; Caballín, Rosa; Elomaa, Inkeri; Knuutila, Sakari
Año de publicación
1998
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.
Facultad de Ciencias Naturales y Museo
Materia
Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/122867
Acceder
id SEDICI_aeeeb9b2a5d9281073b7359ef09a8613
oai_identifier_str oai:sedici.unlp.edu.ar:10915/122867
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization studyLarramendy, Marcelo LuisMajander, PäiviSaarto, TiinaTenhunen, MikkoCaballín, RosaElomaa, InkeriKnuutila, SakariBiologíaCiencias MédicasChromosomal translocationMolecular biologyCytogeneticsFluorescence in situ hybridizationIn situBreast AdenocarcinomaRadiation therapyBreast cancerMetaphaseBiologyAgedBreast Neoplasms/geneticsFemaleHumansMiddle AgedThe frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.Facultad de Ciencias Naturales y Museo1998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf57-62http://sedici.unlp.edu.ar/handle/10915/122867enginfo:eu-repo/semantics/altIdentifier/issn/0165-4608info:eu-repo/semantics/altIdentifier/pmid/9406582info:eu-repo/semantics/altIdentifier/doi/10.1016/s0165-4608(97)00014-9info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-22T17:10:09Zoai:sedici.unlp.edu.ar:10915/122867Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-22 17:10:09.482SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
spellingShingle Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
Larramendy, Marcelo Luis
Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
title_short Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_full Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_fullStr Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_full_unstemmed Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
title_sort Radiation therapy for breast cancer and clonal chromosome translocations: a fluorescence in situ hybridization study
dc.creator.none.fl_str_mv Larramendy, Marcelo Luis
Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
author Larramendy, Marcelo Luis
author_facet Larramendy, Marcelo Luis
Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
author_role author
author2 Majander, Päivi
Saarto, Tiina
Tenhunen, Mikko
Caballín, Rosa
Elomaa, Inkeri
Knuutila, Sakari
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
topic Biología
Ciencias Médicas
Chromosomal translocation
Molecular biology
Cytogenetics
Fluorescence in situ hybridization
In situ
Breast Adenocarcinoma
Radiation therapy
Breast cancer
Metaphase
Biology
Aged
Breast Neoplasms/genetics
Female
Humans
Middle Aged
dc.description.none.fl_txt_mv The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.
Facultad de Ciencias Naturales y Museo
description The frequency of chromosomal translocations was analyzed in skin fibroblast cell cultures derived from irradiated and nonirradiated skin biopsies from five cases of breast adenocarcinoma in women, who had undergone radiotherapy after surgery. The study was performed at the first annual check-up. Chromosomal in situ suppression (CISS) hybridization was performed using metaphase nonisotopic fluorescence in situ hybridization (FISH) with library probes specific for chromosomes 1, 2, 3, 4, 5, 7, 8, 13, 19, and 20. The results showed that the frequency of clonal translocations in metaphases obtained from irradiated areas was significantly higher than in metaphases from the nonirradiated tissue samples.
publishDate 1998
dc.date.none.fl_str_mv 1998
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/122867
url http://sedici.unlp.edu.ar/handle/10915/122867
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0165-4608
info:eu-repo/semantics/altIdentifier/pmid/9406582
info:eu-repo/semantics/altIdentifier/doi/10.1016/s0165-4608(97)00014-9
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
57-62
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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