Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features

Autores
Seifer, Gustavo; Blenkmann, Alejandro; Princich, Juan Pablo; Consalvo, Damián; Papayannis, Cristina; Muravchik, Carlos Horacio; Kochen, Silvia
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Purpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with white matter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance. We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.
Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales
Comisión de Investigaciones Científicas de la provincia de Buenos Aires
Materia
Ingeniería Electrónica
Epilepsia
Neuroimágenes
Imagen por Resonancia Magnética
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123678

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network_name_str SEDICI (UNLP)
spelling Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging FeaturesSeifer, GustavoBlenkmann, AlejandroPrincich, Juan PabloConsalvo, DamiánPapayannis, CristinaMuravchik, Carlos HoracioKochen, SilviaIngeniería ElectrónicaEpilepsiaNeuroimágenesImagen por Resonancia MagnéticaPurpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with white matter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance. We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.Instituto de Investigaciones en Electrónica, Control y Procesamiento de SeñalesComisión de Investigaciones Científicas de la provincia de Buenos Aires2012-03-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/123678enginfo:eu-repo/semantics/altIdentifier/issn/2090-1356info:eu-repo/semantics/altIdentifier/issn/2090-1348info:eu-repo/semantics/altIdentifier/pmid/22957239info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/736784info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:33Zoai:sedici.unlp.edu.ar:10915/123678Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:33.599SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
title Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
spellingShingle Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
Seifer, Gustavo
Ingeniería Electrónica
Epilepsia
Neuroimágenes
Imagen por Resonancia Magnética
title_short Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
title_full Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
title_fullStr Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
title_full_unstemmed Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
title_sort Noninvasive Approach to Focal Cortical Dysplasias: Clinical, EEG, and Neuroimaging Features
dc.creator.none.fl_str_mv Seifer, Gustavo
Blenkmann, Alejandro
Princich, Juan Pablo
Consalvo, Damián
Papayannis, Cristina
Muravchik, Carlos Horacio
Kochen, Silvia
author Seifer, Gustavo
author_facet Seifer, Gustavo
Blenkmann, Alejandro
Princich, Juan Pablo
Consalvo, Damián
Papayannis, Cristina
Muravchik, Carlos Horacio
Kochen, Silvia
author_role author
author2 Blenkmann, Alejandro
Princich, Juan Pablo
Consalvo, Damián
Papayannis, Cristina
Muravchik, Carlos Horacio
Kochen, Silvia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Ingeniería Electrónica
Epilepsia
Neuroimágenes
Imagen por Resonancia Magnética
topic Ingeniería Electrónica
Epilepsia
Neuroimágenes
Imagen por Resonancia Magnética
dc.description.none.fl_txt_mv Purpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with white matter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance. We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.
Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales
Comisión de Investigaciones Científicas de la provincia de Buenos Aires
description Purpose. The main purpose is to define more accurately the epileptogenic zone (EZ) with noninvasive methods in those patients with MRI diagnosis of focal cortical dysplasia (FCD) and epilepsy who are candidates of epilepsy surgery. Methods. Twenty patients were evaluated prospectively between 2007 and 2010 with comprehensive clinical evaluation, video-electroencephalography, diffusion tensor imaging (DTI), and high-resolution EEG to localize the equivalent current dipole (ECD). Key Findings. In 11 cases with white matter asymmetries in DTI the ECDs were located next to lesion on MRI with mean distance of 14.63 millimeters with topographical correlation with the EZ. Significance. We could establish a hypothesis of EZ based on Video-EEG, high-resolution EEG, ECD method, MRI, and DTI. These results are consistent with the hypothesis that the EZ in the FCD is complex and is often larger than visible lesion in MRI.
publishDate 2012
dc.date.none.fl_str_mv 2012-03-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123678
url http://sedici.unlp.edu.ar/handle/10915/123678
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/issn/2090-1348
info:eu-repo/semantics/altIdentifier/pmid/22957239
info:eu-repo/semantics/altIdentifier/doi/10.1155/2012/736784
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
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dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
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instname_str Universidad Nacional de La Plata
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institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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