Deranged sodium to sudden death

Autores
Clancy, Colleen E.; Chen-Izu, Ye; Bers, Donald M.; Belardinelli, Luiz; Boyden, Penelope A.; Csernoch, Laszlo; Despa, Sanda; Fermini, Bernard; Hool, Livia C.; Izu, Leighton; Kass, Robert S.; Lederer, W. Jonathan; Louch, William E.; Maack, Christoph; Mattiazzi, Alicia Ramona; Qu, Zhilin; Rajamani, Sridharan; Rippinger, Crystal M.; Sejersted, Ole M.; O’Rourke, Brian; Weiss, James N.; Varró, Andras; Zaza, Antonio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Neuroscience
Extramural
Cardiac disorders
Sudden death
Sodium channel
Sodium
Homeostasis
Medicine
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/127083

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network_name_str SEDICI (UNLP)
spelling Deranged sodium to sudden deathClancy, Colleen E.Chen-Izu, YeBers, Donald M.Belardinelli, LuizBoyden, Penelope A.Csernoch, LaszloDespa, SandaFermini, BernardHool, Livia C.Izu, LeightonKass, Robert S.Lederer, W. JonathanLouch, William E.Maack, ChristophMattiazzi, Alicia RamonaQu, ZhilinRajamani, SridharanRippinger, Crystal M.Sejersted, Ole M.O’Rourke, BrianWeiss, James N.Varró, AndrasZaza, AntonioCiencias MédicasNeuroscienceExtramuralCardiac disordersSudden deathSodium channelSodiumHomeostasisMedicineIn February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.Centro de Investigaciones Cardiovasculares2015-03-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1331-1345http://sedici.unlp.edu.ar/handle/10915/127083enginfo:eu-repo/semantics/altIdentifier/issn/1469-7793info:eu-repo/semantics/altIdentifier/issn/0022-3751info:eu-repo/semantics/altIdentifier/pmid/25772289info:eu-repo/semantics/altIdentifier/doi/10.1113/jphysiol.2014.281204info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:42Zoai:sedici.unlp.edu.ar:10915/127083Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:43.059SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Deranged sodium to sudden death
title Deranged sodium to sudden death
spellingShingle Deranged sodium to sudden death
Clancy, Colleen E.
Ciencias Médicas
Neuroscience
Extramural
Cardiac disorders
Sudden death
Sodium channel
Sodium
Homeostasis
Medicine
title_short Deranged sodium to sudden death
title_full Deranged sodium to sudden death
title_fullStr Deranged sodium to sudden death
title_full_unstemmed Deranged sodium to sudden death
title_sort Deranged sodium to sudden death
dc.creator.none.fl_str_mv Clancy, Colleen E.
Chen-Izu, Ye
Bers, Donald M.
Belardinelli, Luiz
Boyden, Penelope A.
Csernoch, Laszlo
Despa, Sanda
Fermini, Bernard
Hool, Livia C.
Izu, Leighton
Kass, Robert S.
Lederer, W. Jonathan
Louch, William E.
Maack, Christoph
Mattiazzi, Alicia Ramona
Qu, Zhilin
Rajamani, Sridharan
Rippinger, Crystal M.
Sejersted, Ole M.
O’Rourke, Brian
Weiss, James N.
Varró, Andras
Zaza, Antonio
author Clancy, Colleen E.
author_facet Clancy, Colleen E.
Chen-Izu, Ye
Bers, Donald M.
Belardinelli, Luiz
Boyden, Penelope A.
Csernoch, Laszlo
Despa, Sanda
Fermini, Bernard
Hool, Livia C.
Izu, Leighton
Kass, Robert S.
Lederer, W. Jonathan
Louch, William E.
Maack, Christoph
Mattiazzi, Alicia Ramona
Qu, Zhilin
Rajamani, Sridharan
Rippinger, Crystal M.
Sejersted, Ole M.
O’Rourke, Brian
Weiss, James N.
Varró, Andras
Zaza, Antonio
author_role author
author2 Chen-Izu, Ye
Bers, Donald M.
Belardinelli, Luiz
Boyden, Penelope A.
Csernoch, Laszlo
Despa, Sanda
Fermini, Bernard
Hool, Livia C.
Izu, Leighton
Kass, Robert S.
Lederer, W. Jonathan
Louch, William E.
Maack, Christoph
Mattiazzi, Alicia Ramona
Qu, Zhilin
Rajamani, Sridharan
Rippinger, Crystal M.
Sejersted, Ole M.
O’Rourke, Brian
Weiss, James N.
Varró, Andras
Zaza, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Neuroscience
Extramural
Cardiac disorders
Sudden death
Sodium channel
Sodium
Homeostasis
Medicine
topic Ciencias Médicas
Neuroscience
Extramural
Cardiac disorders
Sudden death
Sodium channel
Sodium
Homeostasis
Medicine
dc.description.none.fl_txt_mv In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.
Centro de Investigaciones Cardiovasculares
description In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-13
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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info:eu-repo/semantics/altIdentifier/doi/10.1113/jphysiol.2014.281204
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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