Deranged sodium to sudden death
- Autores
- Clancy, Colleen E.; Chen-Izu, Ye; Bers, Donald M.; Belardinelli, Luiz; Boyden, Penelope A.; Csernoch, Laszlo; Despa, Sanda; Fermini, Bernard; Hool, Livia C.; Izu, Leighton; Kass, Robert S.; Lederer, W. Jonathan; Louch, William E.; Maack, Christoph; Mattiazzi, Alicia Ramona; Qu, Zhilin; Rajamani, Sridharan; Rippinger, Crystal M.; Sejersted, Ole M.; O’Rourke, Brian; Weiss, James N.; Varró, Andras; Zaza, Antonio
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.
Centro de Investigaciones Cardiovasculares - Materia
-
Ciencias Médicas
Neuroscience
Extramural
Cardiac disorders
Sudden death
Sodium channel
Sodium
Homeostasis
Medicine - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/127083
Ver los metadatos del registro completo
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Deranged sodium to sudden deathClancy, Colleen E.Chen-Izu, YeBers, Donald M.Belardinelli, LuizBoyden, Penelope A.Csernoch, LaszloDespa, SandaFermini, BernardHool, Livia C.Izu, LeightonKass, Robert S.Lederer, W. JonathanLouch, William E.Maack, ChristophMattiazzi, Alicia RamonaQu, ZhilinRajamani, SridharanRippinger, Crystal M.Sejersted, Ole M.O’Rourke, BrianWeiss, James N.Varró, AndrasZaza, AntonioCiencias MédicasNeuroscienceExtramuralCardiac disordersSudden deathSodium channelSodiumHomeostasisMedicineIn February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy.Centro de Investigaciones Cardiovasculares2015-03-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1331-1345http://sedici.unlp.edu.ar/handle/10915/127083enginfo:eu-repo/semantics/altIdentifier/issn/1469-7793info:eu-repo/semantics/altIdentifier/issn/0022-3751info:eu-repo/semantics/altIdentifier/pmid/25772289info:eu-repo/semantics/altIdentifier/doi/10.1113/jphysiol.2014.281204info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:30:42Zoai:sedici.unlp.edu.ar:10915/127083Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:30:43.059SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Deranged sodium to sudden death |
title |
Deranged sodium to sudden death |
spellingShingle |
Deranged sodium to sudden death Clancy, Colleen E. Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine |
title_short |
Deranged sodium to sudden death |
title_full |
Deranged sodium to sudden death |
title_fullStr |
Deranged sodium to sudden death |
title_full_unstemmed |
Deranged sodium to sudden death |
title_sort |
Deranged sodium to sudden death |
dc.creator.none.fl_str_mv |
Clancy, Colleen E. Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio |
author |
Clancy, Colleen E. |
author_facet |
Clancy, Colleen E. Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio |
author_role |
author |
author2 |
Chen-Izu, Ye Bers, Donald M. Belardinelli, Luiz Boyden, Penelope A. Csernoch, Laszlo Despa, Sanda Fermini, Bernard Hool, Livia C. Izu, Leighton Kass, Robert S. Lederer, W. Jonathan Louch, William E. Maack, Christoph Mattiazzi, Alicia Ramona Qu, Zhilin Rajamani, Sridharan Rippinger, Crystal M. Sejersted, Ole M. O’Rourke, Brian Weiss, James N. Varró, Andras Zaza, Antonio |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine |
topic |
Ciencias Médicas Neuroscience Extramural Cardiac disorders Sudden death Sodium channel Sodium Homeostasis Medicine |
dc.description.none.fl_txt_mv |
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy. Centro de Investigaciones Cardiovasculares |
description |
In February 2014, a group of scientists convened as part of the University of California Davis Cardiovascular Symposium to bring together experimental and mathematical modelling perspectives and discuss points of consensus and controversy on the topic of sodium in the heart. This paper summarizes the topics of presentation and discussion from the symposium, with a focus on the role of aberrant sodium channels and abnormal sodium homeostasis in cardiac arrhythmias and pharmacotherapy from the subcellular scale to the whole heart. Two following papers focus on Na⁺ channel structure, function and regulation, and Na⁺/Ca²⁺ exchange and Na⁺/K⁺ ATPase. The UC Davis Cardiovascular Symposium is a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The focus on Na⁺ in the 2014 symposium stemmed from the multitude of recent studies that point to the importance of maintaining Na⁺ homeostasis in the heart, as disruption of homeostatic processes are increasingly identified in cardiac disease states. Understanding how disruption in cardiac Na⁺-based processes leads to derangement in multiple cardiac components at the level of the cell and to then connect these perturbations to emergent behaviour in the heart to cause disease is a critical area of research. The ubiquity of disruption of Na⁺ channels and Na⁺ homeostasis in cardiac disorders of excitability and mechanics emphasizes the importance of a fundamental understanding of the associated mechanisms and disease processes to ultimately reveal new targets for human therapy. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03-13 |
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