Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
- Autores
- Aiello, Ernesto Alejandro; De Giusti, Verónica Celeste
- Año de publicación
- 2013
- Idioma
- español castellano
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The sodium/bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na+ per 1molecule of HCO3- (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na+ per 2 molecules of HCO3- (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pHi and intracellular Na+ concentration, which indirectly, due to the stimulation of the Na+/Ca2+ exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca2+ concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca2+ concentration. The regulation of the intracellular Na+ and Ca2+ concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
Centro de Investigaciones Cardiovasculares - Materia
-
Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/107781
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Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodellingAiello, Ernesto AlejandroDe Giusti, Verónica CelesteCiencias MédicasAngiotensin IICalcium overloadCardiac arrhythmiasCardiac hypertrophyElectrogenic sodium/bicarbonate cotransporterSodium overloadThe sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.Centro de Investigaciones Cardiovasculares2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf24-32http://sedici.unlp.edu.ar/handle/10915/107781spainfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3584305&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/1573-403Xinfo:eu-repo/semantics/altIdentifier/pmid/23116057info:eu-repo/semantics/altIdentifier/doi/10.2174/157340313805076340info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:07Zoai:sedici.unlp.edu.ar:10915/107781Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:07.838SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
title |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
spellingShingle |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling Aiello, Ernesto Alejandro Ciencias Médicas Angiotensin II Calcium overload Cardiac arrhythmias Cardiac hypertrophy Electrogenic sodium/bicarbonate cotransporter Sodium overload |
title_short |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
title_full |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
title_fullStr |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
title_full_unstemmed |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
title_sort |
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling |
dc.creator.none.fl_str_mv |
Aiello, Ernesto Alejandro De Giusti, Verónica Celeste |
author |
Aiello, Ernesto Alejandro |
author_facet |
Aiello, Ernesto Alejandro De Giusti, Verónica Celeste |
author_role |
author |
author2 |
De Giusti, Verónica Celeste |
author2_role |
author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Angiotensin II Calcium overload Cardiac arrhythmias Cardiac hypertrophy Electrogenic sodium/bicarbonate cotransporter Sodium overload |
topic |
Ciencias Médicas Angiotensin II Calcium overload Cardiac arrhythmias Cardiac hypertrophy Electrogenic sodium/bicarbonate cotransporter Sodium overload |
dc.description.none.fl_txt_mv |
The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases. Centro de Investigaciones Cardiovasculares |
description |
The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 |
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