Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling

Autores
Aiello, Ernesto Alejandro; De Giusti, Verónica Celeste
Año de publicación
2013
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The sodium/bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na+ per 1molecule of HCO3- (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na+ per 2 molecules of HCO3- (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pHi and intracellular Na+ concentration, which indirectly, due to the stimulation of the Na+/Ca2+ exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca2+ concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca2+ concentration. The regulation of the intracellular Na+ and Ca2+ concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
Centro de Investigaciones Cardiovasculares
Materia
Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/107781

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spelling Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodellingAiello, Ernesto AlejandroDe Giusti, Verónica CelesteCiencias MédicasAngiotensin IICalcium overloadCardiac arrhythmiasCardiac hypertrophyElectrogenic sodium/bicarbonate cotransporterSodium overloadThe sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.Centro de Investigaciones Cardiovasculares2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf24-32http://sedici.unlp.edu.ar/handle/10915/107781spainfo:eu-repo/semantics/altIdentifier/url/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3584305&blobtype=pdfinfo:eu-repo/semantics/altIdentifier/issn/1573-403Xinfo:eu-repo/semantics/altIdentifier/pmid/23116057info:eu-repo/semantics/altIdentifier/doi/10.2174/157340313805076340info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:56:07Zoai:sedici.unlp.edu.ar:10915/107781Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:56:07.838SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
spellingShingle Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
Aiello, Ernesto Alejandro
Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
title_short Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_full Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_fullStr Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_full_unstemmed Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_sort Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
dc.creator.none.fl_str_mv Aiello, Ernesto Alejandro
De Giusti, Verónica Celeste
author Aiello, Ernesto Alejandro
author_facet Aiello, Ernesto Alejandro
De Giusti, Verónica Celeste
author_role author
author2 De Giusti, Verónica Celeste
author2_role author
dc.subject.none.fl_str_mv Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
topic Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
dc.description.none.fl_txt_mv The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
Centro de Investigaciones Cardiovasculares
description The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
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info:eu-repo/semantics/altIdentifier/pmid/23116057
info:eu-repo/semantics/altIdentifier/doi/10.2174/157340313805076340
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