α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population
- Autores
- Acosta, Karina Beatriz; Lorenzini Campos, M. N.; Etcheverry, Susana B.; Zapata, Pedro D.
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The α6β4 integrin is composed of the α6 and β4 subunits that are encoded by the ITGα6 and the ITGβ4 genes, respectively. The α6β4 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate the potential role of ITGα6 (A380T) and ITGβ4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGα6 (A380T) single nucleotide polymorphism, a high frequency of heterozygous genotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52-1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGα6) and the risk of developing breast cancer. The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature.
Facultad de Ciencias Exactas
Centro de Química Inorgánica - Materia
-
Ciencias Exactas
Breast cancer
Genetic variations
α6β4 integrin - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/86418
Ver los metadatos del registro completo
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α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian populationAcosta, Karina BeatrizLorenzini Campos, M. N.Etcheverry, Susana B.Zapata, Pedro D.Ciencias ExactasBreast cancerGenetic variationsα6β4 integrinThe α6β4 integrin is composed of the α6 and β4 subunits that are encoded by the ITGα6 and the ITGβ4 genes, respectively. The α6β4 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate the potential role of ITGα6 (A380T) and ITGβ4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGα6 (A380T) single nucleotide polymorphism, a high frequency of heterozygous genotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52-1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGα6) and the risk of developing breast cancer. The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature.Facultad de Ciencias ExactasCentro de Química Inorgánica2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/86418enginfo:eu-repo/semantics/altIdentifier/issn/1661-6596info:eu-repo/semantics/altIdentifier/doi/10.3390/ijms17101540info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-01-14T13:41:00Zoai:sedici.unlp.edu.ar:10915/86418Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-01-14 13:41:00.875SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| title |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| spellingShingle |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population Acosta, Karina Beatriz Ciencias Exactas Breast cancer Genetic variations α6β4 integrin |
| title_short |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| title_full |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| title_fullStr |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| title_full_unstemmed |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| title_sort |
α6β4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population |
| dc.creator.none.fl_str_mv |
Acosta, Karina Beatriz Lorenzini Campos, M. N. Etcheverry, Susana B. Zapata, Pedro D. |
| author |
Acosta, Karina Beatriz |
| author_facet |
Acosta, Karina Beatriz Lorenzini Campos, M. N. Etcheverry, Susana B. Zapata, Pedro D. |
| author_role |
author |
| author2 |
Lorenzini Campos, M. N. Etcheverry, Susana B. Zapata, Pedro D. |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Ciencias Exactas Breast cancer Genetic variations α6β4 integrin |
| topic |
Ciencias Exactas Breast cancer Genetic variations α6β4 integrin |
| dc.description.none.fl_txt_mv |
The α6β4 integrin is composed of the α6 and β4 subunits that are encoded by the ITGα6 and the ITGβ4 genes, respectively. The α6β4 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate the potential role of ITGα6 (A380T) and ITGβ4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGα6 (A380T) single nucleotide polymorphism, a high frequency of heterozygous genotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52-1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGα6) and the risk of developing breast cancer. The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature. Facultad de Ciencias Exactas Centro de Química Inorgánica |
| description |
The α6β4 integrin is composed of the α6 and β4 subunits that are encoded by the ITGα6 and the ITGβ4 genes, respectively. The α6β4 main function is to intervene in lamination and epithelia integrity maintenance by cell-matrix interactions. This integrin appears to have importance in breast cancer malignancy, as well as other epithelial carcinomas. The aim of this work was to investigate the potential role of ITGα6 (A380T) and ITGβ4 (R1281W) genetic variations in breast cancer susceptibility, in a female population from the northeast region of Argentina (Misiones). We performed a case-control study of 85 breast cancer patients and 113 cancer-free controls. Genotyping was performed by RFLP-PCR. For ITGα6 (A380T) single nucleotide polymorphism, a high frequency of heterozygous genotype GA in cases compared to controls was observed, achieving values of 48% and 49%, respectively. No association between the A380T SNP and breast cancer development was found (Odds Ratio = 0.92; 95% Confidence Interval = 0.52-1.63; p = 0.884). In conclusion, we did not find evidence of an association between A380T (ITGα6) and the risk of developing breast cancer. The results represent the first report of these genetic variations in breast cancer; therefore, they are an important contribution to the literature. |
| publishDate |
2016 |
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2016 |
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eng |
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