The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells

Autores
Tano de la Hoz, María Florencia; Flamini, Mirta Alicia; Zanuzzi, Carolina Natalia; Díaz, Alcira Ofelia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of Lagostomus maximus to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA/Bh/KOH/ PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti-c-kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of L. maximus. Of all types identified, the ICC-SM were the only cells located solely within the colonic groove.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/104820

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spelling The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cellsTano de la Hoz, María FlorenciaFlamini, Mirta AliciaZanuzzi, Carolina NataliaDíaz, Alcira OfeliaCiencias VeterinariasColonic separation mechanismGlycoconjugatesHystricognathiInterstitial cells of CajalMorphologyThe ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <i>Lagostomus maximus</i> to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA/Bh/KOH/ PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti-c-kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of <i>L. maximus</i>. Of all types identified, the ICC-SM were the only cells located solely within the colonic groove.Facultad de Ciencias Veterinarias2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-13http://sedici.unlp.edu.ar/handle/10915/104820enginfo:eu-repo/semantics/altIdentifier/issn/1097-4687info:eu-repo/semantics/altIdentifier/doi/10.1002/jmor.20735info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:57Zoai:sedici.unlp.edu.ar:10915/104820Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:58.047SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
spellingShingle The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
Tano de la Hoz, María Florencia
Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
title_short The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_full The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_fullStr The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_full_unstemmed The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
title_sort The colonic groove of the plains viscacha (<i>Lagostomus maximus</i>) : Histochemical evidence of an abrupt change in the glycosylation pattern of goblet cells
dc.creator.none.fl_str_mv Tano de la Hoz, María Florencia
Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
author Tano de la Hoz, María Florencia
author_facet Tano de la Hoz, María Florencia
Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
author_role author
author2 Flamini, Mirta Alicia
Zanuzzi, Carolina Natalia
Díaz, Alcira Ofelia
author2_role author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
topic Ciencias Veterinarias
Colonic separation mechanism
Glycoconjugates
Hystricognathi
Interstitial cells of Cajal
Morphology
dc.description.none.fl_txt_mv The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <i>Lagostomus maximus</i> to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA/Bh/KOH/ PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti-c-kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of <i>L. maximus</i>. Of all types identified, the ICC-SM were the only cells located solely within the colonic groove.
Facultad de Ciencias Veterinarias
description The ascending colon of most rodent species shows a longitudinal colonic groove that works as a retrograde transport pathway for a mixture of bacteria and mucus toward the cecum. We describe the morphology and glycosylation pattern of the colonic groove of <i>Lagostomus maximus</i> to analyze the role of mucins in this anatomical feature. We also studied the distribution pattern of the interstitial cells of Cajal (ICC) to evaluate their regulatory influence on gut motility. The groove originated near the cecocolic junction and extended along the mesenteric side of the ascending colon, limited at both ends by nonpapillated ridges. These ridges divided the lumen of the ascending colon into two compartments: a narrow channel and a large channel, called the groove lumen and the main lumen, respectively. The histochemical analysis showed differences in the glycosylation pattern of the goblet cells inside and outside the groove. Unlike the mucosa lining the main lumen of the colon, the groove was rich in goblet cells that secrete sulfomucins. The PA/Bh/KOH/ PAS technique evidenced an abrupt change in the histochemical profile of goblet cells, which presented a negative reaction in the groove and a strongly positive one in the rest of the colonic mucosa. The anti-c-kit immunohistochemical analysis showed different ICC subpopulations in the ascending colon of <i>L. maximus</i>. Of all types identified, the ICC-SM were the only cells located solely within the colonic groove.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
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status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/104820
url http://sedici.unlp.edu.ar/handle/10915/104820
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1097-4687
info:eu-repo/semantics/altIdentifier/doi/10.1002/jmor.20735
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
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