Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder

Autores
Dunne, Margaret R.; Byrne, Greg; Chirdo, Fernando Gabriel; Feighery, Conleth
Año de publicación
2020
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.
Instituto de Estudios Inmunológicos y Fisiopatológicos
Materia
Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/119001

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spelling Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated DisorderDunne, Margaret R.Byrne, GregChirdo, Fernando GabrielFeighery, ConlethBiologíaCoeliac diseasePathogenesisEnteropathyImmunopathologyInnate and adaptive immune responseMolecular mechanisms of diseaseCoeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.Instituto de Estudios Inmunológicos y Fisiopatológicos2020info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/119001enginfo:eu-repo/semantics/altIdentifier/issn/1664-3224info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.01374info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:28:04Zoai:sedici.unlp.edu.ar:10915/119001Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:28:04.769SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
spellingShingle Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
Dunne, Margaret R.
Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
title_short Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_full Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_fullStr Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_full_unstemmed Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_sort Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
dc.creator.none.fl_str_mv Dunne, Margaret R.
Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
author Dunne, Margaret R.
author_facet Dunne, Margaret R.
Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
author_role author
author2 Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
author2_role author
author
author
dc.subject.none.fl_str_mv Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
topic Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
dc.description.none.fl_txt_mv Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.
Instituto de Estudios Inmunológicos y Fisiopatológicos
description Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.
publishDate 2020
dc.date.none.fl_str_mv 2020
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info:eu-repo/semantics/publishedVersion
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dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1664-3224
info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.01374
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
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rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
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