Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
- Autores
- Dunne, Margaret R.; Byrne, Greg; Chirdo, Fernando Gabriel; Feighery, Conleth
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.
Instituto de Estudios Inmunológicos y Fisiopatológicos - Materia
-
Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/119001
Ver los metadatos del registro completo
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Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated DisorderDunne, Margaret R.Byrne, GregChirdo, Fernando GabrielFeighery, ConlethBiologíaCoeliac diseasePathogenesisEnteropathyImmunopathologyInnate and adaptive immune responseMolecular mechanisms of diseaseCoeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.Instituto de Estudios Inmunológicos y Fisiopatológicos2020info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/119001enginfo:eu-repo/semantics/altIdentifier/issn/1664-3224info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2020.01374info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:28:04Zoai:sedici.unlp.edu.ar:10915/119001Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:28:04.769SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
title |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
spellingShingle |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder Dunne, Margaret R. Biología Coeliac disease Pathogenesis Enteropathy Immunopathology Innate and adaptive immune response Molecular mechanisms of disease |
title_short |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
title_full |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
title_fullStr |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
title_full_unstemmed |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
title_sort |
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder |
dc.creator.none.fl_str_mv |
Dunne, Margaret R. Byrne, Greg Chirdo, Fernando Gabriel Feighery, Conleth |
author |
Dunne, Margaret R. |
author_facet |
Dunne, Margaret R. Byrne, Greg Chirdo, Fernando Gabriel Feighery, Conleth |
author_role |
author |
author2 |
Byrne, Greg Chirdo, Fernando Gabriel Feighery, Conleth |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
Biología Coeliac disease Pathogenesis Enteropathy Immunopathology Innate and adaptive immune response Molecular mechanisms of disease |
topic |
Biología Coeliac disease Pathogenesis Enteropathy Immunopathology Innate and adaptive immune response Molecular mechanisms of disease |
dc.description.none.fl_txt_mv |
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease. Instituto de Estudios Inmunológicos y Fisiopatológicos |
description |
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 |
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review |
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eng |
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eng |
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