Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in...

Autores
Bonansea, Rocio Ines; Marino, Damián José Gabriel; Bertrand, Lidwina; Wunderlin, Daniel Alberto; Amé, María Valeria
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.
Centro de Investigaciones del Medioambiente
Materia
Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/101215
Acceder
id SEDICI_9eb90cc2da5ffd1b6db83ec30ca76092
oai_identifier_str oai:sedici.unlp.edu.ar:10915/101215
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixturesBonansea, Rocio InesMarino, Damián José GabrielBertrand, LidwinaWunderlin, Daniel AlbertoAmé, María ValeriaCiencias NaturalesGas chromatography electron capture detectorHigh-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzerMetabolismMixturesTissue distributionThe aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.Centro de Investigaciones del Medioambiente2016-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1764-1774http://sedici.unlp.edu.ar/handle/10915/101215enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/48047info:eu-repo/semantics/altIdentifier/issn/0730-7268info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.3613info:eu-repo/semantics/altIdentifier/hdl/11336/48047info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:21:01Zoai:sedici.unlp.edu.ar:10915/101215Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:21:01.684SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
spellingShingle Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
Bonansea, Rocio Ines
Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
title_short Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_full Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_fullStr Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_full_unstemmed Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
title_sort Tissue-specific bioconcentration and biotransformation of cypermethrin and chlorpyrifos in a native fish (<i>Jenynsia multidentata</i>) exposed to these insecticides singly and in mixtures
dc.creator.none.fl_str_mv Bonansea, Rocio Ines
Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
author Bonansea, Rocio Ines
author_facet Bonansea, Rocio Ines
Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
author_role author
author2 Marino, Damián José Gabriel
Bertrand, Lidwina
Wunderlin, Daniel Alberto
Amé, María Valeria
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
topic Ciencias Naturales
Gas chromatography electron capture detector
High-performance liquid chromatography electrospray ionization source quadrupole time-of-flight analyzer
Metabolism
Mixtures
Tissue distribution
dc.description.none.fl_txt_mv The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.
Centro de Investigaciones del Medioambiente
description The aim of the present study was to evaluate the accumulation of cypermethrin and chlorpyrifos when the fish Jenynsia multidentata was exposed to these pesticides singly and in technical and commercial mixtures. Adult female fish were exposed over 96 h to 0.04 μg/L of cypermethrin; 0.4 μg/L of chlorpyrifos; 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a technical mixture; and 0.04 μg/L of cypermethrin + 0.4 μg/L of chlorpyrifos in a mixture of commercial products. Fish exposed to cypermethrin accumulated this compound only in muscle, probably because of the low biotransformation capacity of this organ and the induction of cytochrome P4501A1 (CYP1A1) expression in the liver. The accumulation of chlorpyrifos occurred in fish exposed to the insecticide (intestine > liver > gills) even when these fish had higher gluthatione-S-transferase (GST) activin gills and P-glycoprotein (P-gp) expression in the liver, compared with the control. Fish exposed to the technical mixture showed cypermethrin accumulation (liver > intestine > gills) with higher levels than those measured in fish after only cypermethrin exposure. Higher expression levels of CYP1A1 in the liver were also observed compared with the Control. Fish exposed to the commercial mixture accumulated both insecticides (cypermethrin: intestine > gills and chlorpyrifos: liver > intestine > gills > muscle). In the organs where accumulation occurred, biotransformation enzymes were inhibited. Consequently, the commercial formulation exposure provoked the highest accumulation of cypermethrin and chlorpyrifos in J. multidentata, possibly associated with the biotransformation system inhibition.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/101215
url http://sedici.unlp.edu.ar/handle/10915/101215
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/48047
info:eu-repo/semantics/altIdentifier/issn/0730-7268
info:eu-repo/semantics/altIdentifier/doi/10.1002/etc.3613
info:eu-repo/semantics/altIdentifier/hdl/11336/48047
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1764-1774
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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