Estabilidad térmica en endoperoxidos en solución: Ascaridol

Autores
Jeandupex, Rene; Romanelli, Gustavo Pablo; Cafferata, Lázaro F. R.
Año de publicación
2002
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical properties reported for ascaridole, a cyclic endoperoxide isolated from the vegetal named Paico and also from synthetic procedures by photoxygenation of a-tcrpinene, are significantly differents. This lead lo perform the preparation of that substance by Schenck's method, but working al OºC and doing its separalion and purification al room tcmperature by preparative column chromatography .. Excelcnt yields of ascaridol were obtained (ca. 80 % GCFID) of high degree of purity (>98 %, GC; RPHPLC; NMR, 1H, 13C). The thermal stability of ascaridole in solution is advanced, reporting the activation parameters values for the unimolecular decomposition of that substance in isopropyl alcohol.
Laboratorio de Estudio de Compuestos Orgánicos
Centro de Investigación y Desarrollo en Ciencias Aplicadas
Materia
Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/96089
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/96089
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Estabilidad térmica en endoperoxidos en solución: AscaridolJeandupex, ReneRomanelli, Gustavo PabloCafferata, Lázaro F. R.QuímicaEndoperoxides-ascaridoleThermal stabilityAtimalarial agentsEndoperóxidosAscaridolEstabilidad termicaAntimaláricosThe importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical properties reported for ascaridole, a cyclic endoperoxide isolated from the vegetal named Paico and also from synthetic procedures by photoxygenation of a-tcrpinene, are significantly differents. This lead lo perform the preparation of that substance by Schenck's method, but working al OºC and doing its separalion and purification al room tcmperature by preparative column chromatography .. Excelcnt yields of ascaridol were obtained (ca. 80 % GCFID) of high degree of purity (>98 %, GC; RPHPLC; NMR, 1H, 13C). The thermal stability of ascaridole in solution is advanced, reporting the activation parameters values for the unimolecular decomposition of that substance in isopropyl alcohol.Laboratorio de Estudio de Compuestos OrgánicosCentro de Investigación y Desarrollo en Ciencias Aplicadas2002-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf63-66http://sedici.unlp.edu.ar/handle/10915/96089spainfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/63652info:eu-repo/semantics/altIdentifier/issn/2078-3949info:eu-repo/semantics/altIdentifier/hdl/11336/63652info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:20:16Zoai:sedici.unlp.edu.ar:10915/96089Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:20:17.116SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Estabilidad térmica en endoperoxidos en solución: Ascaridol
title Estabilidad térmica en endoperoxidos en solución: Ascaridol
spellingShingle Estabilidad térmica en endoperoxidos en solución: Ascaridol
Jeandupex, Rene
Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
title_short Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_full Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_fullStr Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_full_unstemmed Estabilidad térmica en endoperoxidos en solución: Ascaridol
title_sort Estabilidad térmica en endoperoxidos en solución: Ascaridol
dc.creator.none.fl_str_mv Jeandupex, Rene
Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
author Jeandupex, Rene
author_facet Jeandupex, Rene
Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
author_role author
author2 Romanelli, Gustavo Pablo
Cafferata, Lázaro F. R.
author2_role author
author
dc.subject.none.fl_str_mv Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
topic Química
Endoperoxides-ascaridole
Thermal stability
Atimalarial agents
Endoperóxidos
Ascaridol
Estabilidad termica
Antimaláricos
dc.description.none.fl_txt_mv The importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical properties reported for ascaridole, a cyclic endoperoxide isolated from the vegetal named Paico and also from synthetic procedures by photoxygenation of a-tcrpinene, are significantly differents. This lead lo perform the preparation of that substance by Schenck's method, but working al OºC and doing its separalion and purification al room tcmperature by preparative column chromatography .. Excelcnt yields of ascaridol were obtained (ca. 80 % GCFID) of high degree of purity (>98 %, GC; RPHPLC; NMR, 1H, 13C). The thermal stability of ascaridole in solution is advanced, reporting the activation parameters values for the unimolecular decomposition of that substance in isopropyl alcohol.
Laboratorio de Estudio de Compuestos Orgánicos
Centro de Investigación y Desarrollo en Ciencias Aplicadas
description The importance of cyclic peroxides as the substituted I ,2,4-trioxanes, 1,2,4,5-tetroxanes and endoperoxides has grown considerably in recent years ever since the naturally occurring trioxanc artemisinine and some of its dcrivatives achievcd prominence as potent antimalarial agents. Physical properties reported for ascaridole, a cyclic endoperoxide isolated from the vegetal named Paico and also from synthetic procedures by photoxygenation of a-tcrpinene, are significantly differents. This lead lo perform the preparation of that substance by Schenck's method, but working al OºC and doing its separalion and purification al room tcmperature by preparative column chromatography .. Excelcnt yields of ascaridol were obtained (ca. 80 % GCFID) of high degree of purity (>98 %, GC; RPHPLC; NMR, 1H, 13C). The thermal stability of ascaridole in solution is advanced, reporting the activation parameters values for the unimolecular decomposition of that substance in isopropyl alcohol.
publishDate 2002
dc.date.none.fl_str_mv 2002-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/96089
url http://sedici.unlp.edu.ar/handle/10915/96089
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/63652
info:eu-repo/semantics/altIdentifier/issn/2078-3949
info:eu-repo/semantics/altIdentifier/hdl/11336/63652
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
63-66
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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