Arterial Stiffness: Its Relation with Prediabetes and Metabolic Syndrome and Possible Pathogenesis

• Autores: Gagliardino, Juan José; Salazar, Martín R.; Espeche, Walter Gastón; Tolosa Chapasian, Paula; Gomez Garizoain, Daniela; Olano, Ricardo Daniel; Stavile, Rodolfo Nicolás; Balbín, Eduardo; Martínez, Camilo; Leiva Sisnieguez, Betty Cecilia; Leiva Sisnieguez, Carlos Enrique; Carbajal, Horacio Antonio
• Año de publicación: 2021
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Ciencias Médicas; pulse wave velocity; OGTT; prediabetes; TG/HDL ratio; dyslipidemia; arterial stiffness
• Institución: Universidad Nacional de La Plata

Aims: To evaluate arterial stiffness indicators in people with prediabetes (PreD) and its possible pathogenesis. Materials and methods: Pulse wave velocity (PWV) was measured in 208 people with FINDRISC ≥ 13 (57 ± 8 years old, 68.7% women) and thereafter divided into those having either normal glucose tolerance (NGT) or PreD. In each subgroup we also identified those with/out insulin resistance (IR) measured by the triglyceride/HDL-c ratio (normal cut off values previously established in our population). Clinical and metabolic data were collected for all participants. PWV was compared between subgroups using independent t test. Results: Women and men had comparable clinical and metabolic characteristics with obesity (BMI ≥ 30) and antihypertensive-statin treatment, almost half with either NGT or PreD. Whereas 48% of NGT people presented IR (abnormally high TG/HDL-c ratio), 52% had PreD. PWV was significantly higher only in those with a complete picture of metabolic syndrome (MS). Conclusions: Since PWV was significantly impaired in people with a complete picture of MS, clinicians must carefully search for early diagnosis of this condition and prescribe a healthy life-style to prevent development/progression of CVD. This proactive attitude would provide a cost-effective preventive strategy to avoid CVD’s negative impact on patients’ quality of life and on health systems due to their higher care costs.
Centro de Endocrinología Experimental y Aplicada
Facultad de Ciencias Médicas