Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access

Autores
Bia, Daniel; Galli, Cintia Nora; Zócalo, Yanina; Valtuille, Rodolfo; Wray, Sandra; Pessana, Franco Martin; Cabrera Fischer, Edmundo Ignacio
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained on the side of the body where the VA was placed and compare them to its contralateral intact side. Since it is difficult to adequately measure cr-PWV in patients with a VA in the forearm, we measured the carotid-brachial PWV (cb-PWV) and used it to calculate PWV-ratio (cf-PWV/cb-PWV). Methods: A Pearson’s correlation and Bland & Altman analysis were performed in hemodialyzed (n=135) and non-hemodialyzed (n=77) patients, to quantify the equivalence between arterial stiffness parameters (cf-PWV, cb-PWV, PWV-ratio) obtained on each side of the body with respect to its contralateral side. Results: We conclude that PWV-ratio values measured on the side where the VA is placed were significantly higher than those obtained in its contralateral side, in hemodialyzed patients included in this research. Moreover, cf-PWV, cb-PWV and PWV-ratio values obtained on one side of the body were always highly correlated with its contralateral side. Conclusion: According to this research, any research involving PWV-ratio should always consider the observed territory.
Fil: Bia, Daniel. Universidad de la República; Uruguay
Fil: Galli, Cintia Nora. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Zócalo, Yanina. Universidad de la República; Uruguay
Fil: Valtuille, Rodolfo. Fresenius FME; Argentina
Fil: Wray, Sandra. Universidad Favaloro; Argentina
Fil: Pessana, Franco Martin. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Fil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina. Universidad Favaloro; Argentina
Materia
AORTIC STIFFNESS
ARTERIAL STIFFNESS
HEMODIALYSIS
PULSE WAVE VELOCITY
PWV-RATIO
TERRITORY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87746
Acceder
id CONICETDig_a2282392579ff15fd73953a04665745f
oai_identifier_str oai:ri.conicet.gov.ar:11336/87746
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular accessBia, DanielGalli, Cintia NoraZócalo, YaninaValtuille, RodolfoWray, SandraPessana, Franco MartinCabrera Fischer, Edmundo IgnacioAORTIC STIFFNESSARTERIAL STIFFNESSHEMODIALYSISPULSE WAVE VELOCITYPWV-RATIOTERRITORYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained on the side of the body where the VA was placed and compare them to its contralateral intact side. Since it is difficult to adequately measure cr-PWV in patients with a VA in the forearm, we measured the carotid-brachial PWV (cb-PWV) and used it to calculate PWV-ratio (cf-PWV/cb-PWV). Methods: A Pearson’s correlation and Bland & Altman analysis were performed in hemodialyzed (n=135) and non-hemodialyzed (n=77) patients, to quantify the equivalence between arterial stiffness parameters (cf-PWV, cb-PWV, PWV-ratio) obtained on each side of the body with respect to its contralateral side. Results: We conclude that PWV-ratio values measured on the side where the VA is placed were significantly higher than those obtained in its contralateral side, in hemodialyzed patients included in this research. Moreover, cf-PWV, cb-PWV and PWV-ratio values obtained on one side of the body were always highly correlated with its contralateral side. Conclusion: According to this research, any research involving PWV-ratio should always consider the observed territory.Fil: Bia, Daniel. Universidad de la República; UruguayFil: Galli, Cintia Nora. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; ArgentinaFil: Zócalo, Yanina. Universidad de la República; UruguayFil: Valtuille, Rodolfo. Fresenius FME; ArgentinaFil: Wray, Sandra. Universidad Favaloro; ArgentinaFil: Pessana, Franco Martin. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; ArgentinaFil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina. Universidad Favaloro; ArgentinaBentham Science Publishers2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/87746Bia, Daniel; Galli, Cintia Nora; Zócalo, Yanina; Valtuille, Rodolfo; Wray, Sandra; et al.; Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access; Bentham Science Publishers; Current Hypertension Reviews; 14; 2; 11-2018; 128-1361573-40211875-6506CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2174/1573402114666180413122055info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/161258/articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:42Zoai:ri.conicet.gov.ar:11336/87746instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:43.03CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
title Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
spellingShingle Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
Bia, Daniel
AORTIC STIFFNESS
ARTERIAL STIFFNESS
HEMODIALYSIS
PULSE WAVE VELOCITY
PWV-RATIO
TERRITORY
title_short Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
title_full Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
title_fullStr Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
title_full_unstemmed Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
title_sort Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access
dc.creator.none.fl_str_mv Bia, Daniel
Galli, Cintia Nora
Zócalo, Yanina
Valtuille, Rodolfo
Wray, Sandra
Pessana, Franco Martin
Cabrera Fischer, Edmundo Ignacio
author Bia, Daniel
author_facet Bia, Daniel
Galli, Cintia Nora
Zócalo, Yanina
Valtuille, Rodolfo
Wray, Sandra
Pessana, Franco Martin
Cabrera Fischer, Edmundo Ignacio
author_role author
author2 Galli, Cintia Nora
Zócalo, Yanina
Valtuille, Rodolfo
Wray, Sandra
Pessana, Franco Martin
Cabrera Fischer, Edmundo Ignacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AORTIC STIFFNESS
ARTERIAL STIFFNESS
HEMODIALYSIS
PULSE WAVE VELOCITY
PWV-RATIO
TERRITORY
topic AORTIC STIFFNESS
ARTERIAL STIFFNESS
HEMODIALYSIS
PULSE WAVE VELOCITY
PWV-RATIO
TERRITORY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained on the side of the body where the VA was placed and compare them to its contralateral intact side. Since it is difficult to adequately measure cr-PWV in patients with a VA in the forearm, we measured the carotid-brachial PWV (cb-PWV) and used it to calculate PWV-ratio (cf-PWV/cb-PWV). Methods: A Pearson’s correlation and Bland & Altman analysis were performed in hemodialyzed (n=135) and non-hemodialyzed (n=77) patients, to quantify the equivalence between arterial stiffness parameters (cf-PWV, cb-PWV, PWV-ratio) obtained on each side of the body with respect to its contralateral side. Results: We conclude that PWV-ratio values measured on the side where the VA is placed were significantly higher than those obtained in its contralateral side, in hemodialyzed patients included in this research. Moreover, cf-PWV, cb-PWV and PWV-ratio values obtained on one side of the body were always highly correlated with its contralateral side. Conclusion: According to this research, any research involving PWV-ratio should always consider the observed territory.
Fil: Bia, Daniel. Universidad de la República; Uruguay
Fil: Galli, Cintia Nora. Gobierno de la Ciudad de Buenos Aires. Hospital de Agudos "D. F. Santojanni"; Argentina
Fil: Zócalo, Yanina. Universidad de la República; Uruguay
Fil: Valtuille, Rodolfo. Fresenius FME; Argentina
Fil: Wray, Sandra. Universidad Favaloro; Argentina
Fil: Pessana, Franco Martin. Universidad Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina
Fil: Cabrera Fischer, Edmundo Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional, Trasplante y Bioingeniería. Fundación Favaloro. Instituto de Medicina Traslacional, Trasplante y Bioingeniería; Argentina. Universidad Favaloro; Argentina
description Background: Pulse wave velocity ratio (PWV-ratio), a measure of central-to-peripheral arterial stiffness gradient, is calculated as a quotient between carotid-femoral and carotid-radial PWV (cf-PWV/cr-PWV). This new index has been reported to be significantly associated with increased mortality in hemodialyzed patients. Since several reports showed differences in arterial stiffness regarding the pathway where the vascular access (VA) is, the purpose of this research was: a) to compare arterial stiffness values obtained in the left and right sides of the body in hemodialyzed and non-hemodialyzed patients, and b) to analyze PWV-ratio values obtained on the side of the body where the VA was placed and compare them to its contralateral intact side. Since it is difficult to adequately measure cr-PWV in patients with a VA in the forearm, we measured the carotid-brachial PWV (cb-PWV) and used it to calculate PWV-ratio (cf-PWV/cb-PWV). Methods: A Pearson’s correlation and Bland & Altman analysis were performed in hemodialyzed (n=135) and non-hemodialyzed (n=77) patients, to quantify the equivalence between arterial stiffness parameters (cf-PWV, cb-PWV, PWV-ratio) obtained on each side of the body with respect to its contralateral side. Results: We conclude that PWV-ratio values measured on the side where the VA is placed were significantly higher than those obtained in its contralateral side, in hemodialyzed patients included in this research. Moreover, cf-PWV, cb-PWV and PWV-ratio values obtained on one side of the body were always highly correlated with its contralateral side. Conclusion: According to this research, any research involving PWV-ratio should always consider the observed territory.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87746
Bia, Daniel; Galli, Cintia Nora; Zócalo, Yanina; Valtuille, Rodolfo; Wray, Sandra; et al.; Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access; Bentham Science Publishers; Current Hypertension Reviews; 14; 2; 11-2018; 128-136
1573-4021
1875-6506
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87746
identifier_str_mv Bia, Daniel; Galli, Cintia Nora; Zócalo, Yanina; Valtuille, Rodolfo; Wray, Sandra; et al.; Central-to-peripheral arterial stiffness gradient in hemodialyzed patients depends on the location of the upper-limb vascular access; Bentham Science Publishers; Current Hypertension Reviews; 14; 2; 11-2018; 128-136
1573-4021
1875-6506
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2174/1573402114666180413122055
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/161258/article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269596936044544
score 13.13397

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