Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals
- Autores
- Meneses, María Laura; Albarellos, G. A.; Landoni, María Fabiana
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The increase in bacterial resistance to antimicrobials has motivated researchers to develop experimental animal models to integrate pharmacokinetic/pharmacodynamic (PK/ PD) profiles to predict the effectiveness of antimicrobials treatments. The models used to date have a weakness based on the use of the minimum inhibitory concentration (MIC), whose value is obtained only in vitro , determined under constant conditions with an exponential error, regarding to the double dilution used. The aim of this study was to develop and validate a device for subcutaneous implantation, which can be applied in any animal species, allowing simultaneous description of in vivo bacterial killing curve and pharmacokinetic profile of the drug under study. Based on the obtained results, it can be concluded that the use of this model will allow researchers to apply PK/ PD decreasing the error originated in the use of MIC as a measure of antimicrobial pharmacodynamics.
Facultad de Ciencias Veterinarias - Materia
-
Ciencias Veterinarias
Pharmacokinetic
Pharmacodynamic
Minimum inhibitory concentration
Antimicrobials - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/124137
Ver los metadatos del registro completo
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Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animalsMeneses, María LauraAlbarellos, G. A.Landoni, María FabianaCiencias VeterinariasPharmacokineticPharmacodynamicMinimum inhibitory concentrationAntimicrobialsThe increase in bacterial resistance to antimicrobials has motivated researchers to develop experimental animal models to integrate pharmacokinetic/pharmacodynamic (PK/ PD) profiles to predict the effectiveness of antimicrobials treatments. The models used to date have a weakness based on the use of the minimum inhibitory concentration (MIC), whose value is obtained only in vitro , determined under constant conditions with an exponential error, regarding to the double dilution used. The aim of this study was to develop and validate a device for subcutaneous implantation, which can be applied in any animal species, allowing simultaneous description of in vivo bacterial killing curve and pharmacokinetic profile of the drug under study. Based on the obtained results, it can be concluded that the use of this model will allow researchers to apply PK/ PD decreasing the error originated in the use of MIC as a measure of antimicrobial pharmacodynamics.Facultad de Ciencias Veterinarias2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/124137enginfo:eu-repo/semantics/altIdentifier/issn/2038-9698info:eu-repo/semantics/altIdentifier/issn/2038-9701info:eu-repo/semantics/altIdentifier/doi/10.4081/vsd.2012.3760info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:21:27Zoai:sedici.unlp.edu.ar:10915/124137Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:21:27.232SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| title |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| spellingShingle |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals Meneses, María Laura Ciencias Veterinarias Pharmacokinetic Pharmacodynamic Minimum inhibitory concentration Antimicrobials |
| title_short |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| title_full |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| title_fullStr |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| title_full_unstemmed |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| title_sort |
Development and validation of an in vivo model for pharmacokinetic/pharmacodynamic studies of antimicrobials in domestic animals |
| dc.creator.none.fl_str_mv |
Meneses, María Laura Albarellos, G. A. Landoni, María Fabiana |
| author |
Meneses, María Laura |
| author_facet |
Meneses, María Laura Albarellos, G. A. Landoni, María Fabiana |
| author_role |
author |
| author2 |
Albarellos, G. A. Landoni, María Fabiana |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
Ciencias Veterinarias Pharmacokinetic Pharmacodynamic Minimum inhibitory concentration Antimicrobials |
| topic |
Ciencias Veterinarias Pharmacokinetic Pharmacodynamic Minimum inhibitory concentration Antimicrobials |
| dc.description.none.fl_txt_mv |
The increase in bacterial resistance to antimicrobials has motivated researchers to develop experimental animal models to integrate pharmacokinetic/pharmacodynamic (PK/ PD) profiles to predict the effectiveness of antimicrobials treatments. The models used to date have a weakness based on the use of the minimum inhibitory concentration (MIC), whose value is obtained only in vitro , determined under constant conditions with an exponential error, regarding to the double dilution used. The aim of this study was to develop and validate a device for subcutaneous implantation, which can be applied in any animal species, allowing simultaneous description of in vivo bacterial killing curve and pharmacokinetic profile of the drug under study. Based on the obtained results, it can be concluded that the use of this model will allow researchers to apply PK/ PD decreasing the error originated in the use of MIC as a measure of antimicrobial pharmacodynamics. Facultad de Ciencias Veterinarias |
| description |
The increase in bacterial resistance to antimicrobials has motivated researchers to develop experimental animal models to integrate pharmacokinetic/pharmacodynamic (PK/ PD) profiles to predict the effectiveness of antimicrobials treatments. The models used to date have a weakness based on the use of the minimum inhibitory concentration (MIC), whose value is obtained only in vitro , determined under constant conditions with an exponential error, regarding to the double dilution used. The aim of this study was to develop and validate a device for subcutaneous implantation, which can be applied in any animal species, allowing simultaneous description of in vivo bacterial killing curve and pharmacokinetic profile of the drug under study. Based on the obtained results, it can be concluded that the use of this model will allow researchers to apply PK/ PD decreasing the error originated in the use of MIC as a measure of antimicrobial pharmacodynamics. |
| publishDate |
2012 |
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2012 |
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eng |
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eng |
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