Controlled release biopolymers for enhancing the immune response

Autores
Castro, Guillermo Raúl; Panilaitis, Bruce; Bora, Emilia; Kaplan, David L.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Materia
Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/152990

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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Controlled release biopolymers for enhancing the immune responseCastro, Guillermo RaúlPanilaitis, BruceBora, EmiliaKaplan, David L.BioquímicaQuímicaBiologíaEmulsanβ-glucanControlled releaseImmunopotentiationDrug deliveryAcinetobacterControlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles.Centro de Investigación y Desarrollo en Fermentaciones Industriales2007info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/152990enginfo:eu-repo/semantics/altIdentifier/issn/1543-8392info:eu-repo/semantics/altIdentifier/doi/10.1021/mp060100xinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T11:11:34Zoai:sedici.unlp.edu.ar:10915/152990Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 11:11:35.089SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Controlled release biopolymers for enhancing the immune response
title Controlled release biopolymers for enhancing the immune response
spellingShingle Controlled release biopolymers for enhancing the immune response
Castro, Guillermo Raúl
Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
title_short Controlled release biopolymers for enhancing the immune response
title_full Controlled release biopolymers for enhancing the immune response
title_fullStr Controlled release biopolymers for enhancing the immune response
title_full_unstemmed Controlled release biopolymers for enhancing the immune response
title_sort Controlled release biopolymers for enhancing the immune response
dc.creator.none.fl_str_mv Castro, Guillermo Raúl
Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
author Castro, Guillermo Raúl
author_facet Castro, Guillermo Raúl
Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
author_role author
author2 Panilaitis, Bruce
Bora, Emilia
Kaplan, David L.
author2_role author
author
author
dc.subject.none.fl_str_mv Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
topic Bioquímica
Química
Biología
Emulsan
β-glucan
Controlled release
Immunopotentiation
Drug delivery
Acinetobacter
dc.description.none.fl_txt_mv Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
description Controlled release of biologically active compounds in the context of drug and vaccine delivery is an important area of research with broad implications in many areas of medicine. In particular, the challenges of oral delivery are of specific interest to reduce the cost and potential health risks related to parenteral administration of pharmaceuticals and vaccine formulations. We discuss the biological activities of two biopolymers, β-glucans and emulsans, both of which offer significant potential for individual formulations related to drug impact, while in combination offer synergistic opportunities in terms of formulation and delivery. β-Glucans have been established as potent immunomodulatory and biologically active compounds with application in a wide range of disease systems. The emulsan family of biopolymers also has significant potential in vaccine and drug delivery based on recent studies. Each of these biopolymers offers exciting opportunities to modulate biological responses via control of chemistry and physical properties achieved during biosynthesis or postsynthesis modifications. When combined into a delivery system for controlled release, synergistic outcomes may be achieved that offer new and exciting opportunities as described in the present paper. These outcomes represent the combined improvements of solubility in physiological environments and immunomodulation due to the specific chemistry and structures involved. Overall, this approach provides a new direction in controlled release wherein the biomaterial carrier, in this case emulsan, and the drug, in this case β-glucan, play an active role both in biological activation as well as in delivery profiles.
publishDate 2007
dc.date.none.fl_str_mv 2007
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info:eu-repo/semantics/publishedVersion
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language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1543-8392
info:eu-repo/semantics/altIdentifier/doi/10.1021/mp060100x
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Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
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rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
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