A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam

Autores
Machicote, Roberta Grisel; Castillo, Marcela A.; Pacheco, María Emilia; Bruzzone, Liliana
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )eselected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.
Facultad de Ciencias Exactas
Laboratorio de Investigación y Desarrollo de Métodos Analíticos (LIDMA)
Materia
Química
benzodiazepines
oxazepam
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/3.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/81069
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/81069
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for OxazepamMachicote, Roberta GriselCastillo, Marcela A.Pacheco, María EmiliaBruzzone, LilianaQuímicabenzodiazepinesoxazepamA flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )eselected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.Facultad de Ciencias ExactasLaboratorio de Investigación y Desarrollo de Métodos Analíticos (LIDMA)2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/81069enginfo:eu-repo/semantics/altIdentifier/issn/2090-8873info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/6302609info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:01Zoai:sedici.unlp.edu.ar:10915/81069Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:01.906SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
spellingShingle A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
Machicote, Roberta Grisel
Química
benzodiazepines
oxazepam
title_short A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_full A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_fullStr A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_full_unstemmed A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
title_sort A Molecular Imprinted Polymer as a Flow-Through Optical Sensor for Oxazepam
dc.creator.none.fl_str_mv Machicote, Roberta Grisel
Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
author Machicote, Roberta Grisel
author_facet Machicote, Roberta Grisel
Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
author_role author
author2 Castillo, Marcela A.
Pacheco, María Emilia
Bruzzone, Liliana
author2_role author
author
author
dc.subject.none.fl_str_mv Química
benzodiazepines
oxazepam
topic Química
benzodiazepines
oxazepam
dc.description.none.fl_txt_mv A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )eselected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.
Facultad de Ciencias Exactas
Laboratorio de Investigación y Desarrollo de Métodos Analíticos (LIDMA)
description A flow-through optosensing system for oxazepam recognition with fluorescence detection was performed by means of a molecular imprinted polymer based on its acid hydrolysis product, 2-amino-5-chlorobenzophenone. )e synthesis was conducted via a noncovalent imprinting methodology, using methacrylic acid as a functional monomer and ethylene glycol dimethacrylate as a cross-linking agent. Hydrolysis (types and concentration of acids), polymer retention capacity, binding properties, and elution (selectivity and reversibility) conditions were optimized. )eselected molecular imprinted polymer had a molar ratio composition of 1 : 6 : 45 (template : functional monomer : cross-linker). )e proposed method was applied to the determination of oxazepam in a pharmaceutical formulation. External standard calibration, standard additions calibration, and Youden’s calibration were carried out in order to evaluate constant and proportional errors due to the matrix. )e developed metabolite-based recognition system for benzodiazepines is an innovative procedure that could be followed in routine and quality control assays.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/81069
url http://sedici.unlp.edu.ar/handle/10915/81069
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2090-8873
info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/6302609
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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