The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection

Autores
Curciarello, Renata; Steele, Alison; Cooper, Dianne; Macdonald, Thomas T.; Kruidenier, Lauren; Takahiro, Kudo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Materia
Biología
Ciencias Naturales
Ciencias Exactas
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/104084
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/104084
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infectionCurciarello, RenataSteele, AlisonCooper, DianneMacdonald, Thomas T.Kruidenier, LaurenTakahiro, KudoBiologíaCiencias NaturalesCiencias ExactasGalectinsGastrointestinal tractCitrobacter rodentium infectionGalectin deficient miceMucosaDespite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with <i>C. rodentium</i> and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on <i>C. rodentium</i> infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.Centro de Investigación y Desarrollo en Criotecnología de Alimentos2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-8http://sedici.unlp.edu.ar/handle/10915/104084enginfo:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/10704info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933info:eu-repo/semantics/altIdentifier/issn/1932-6203info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0107933info:eu-repo/semantics/altIdentifier/hdl/11336/10704info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:42Zoai:sedici.unlp.edu.ar:10915/104084Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:43.064SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
spellingShingle The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
Curciarello, Renata
Biología
Ciencias Naturales
Ciencias Exactas
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
title_short The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_full The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_fullStr The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_full_unstemmed The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
title_sort The role of Galectin-1 and Galectin-3 in the mucosal immune response to <i>Citrobacter rodentium</i> infection
dc.creator.none.fl_str_mv Curciarello, Renata
Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author Curciarello, Renata
author_facet Curciarello, Renata
Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author_role author
author2 Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Biología
Ciencias Naturales
Ciencias Exactas
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
topic Biología
Ciencias Naturales
Ciencias Exactas
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
dc.description.none.fl_txt_mv Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with <i>C. rodentium</i> and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on <i>C. rodentium</i> infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
description Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the <i>Citrobacter rodentium</i> model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with <i>C. rodentium</i> and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on <i>C. rodentium</i> infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/104084
url http://sedici.unlp.edu.ar/handle/10915/104084
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/10704
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933
info:eu-repo/semantics/altIdentifier/issn/1932-6203
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0107933
info:eu-repo/semantics/altIdentifier/hdl/11336/10704
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
1-8
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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