The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection

Autores
Curciarello, Renata; Steele, Alison; Cooper, Dianne; Macdonald, Thomas T.; Kruidenier, Lauren; Takahiro, Kudo
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Steele, Alison. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Cooper, Dianne. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute; Reino Unido
Fil: Macdonald, Thomas T.. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Kruidenier, Lauren. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Takahiro, Kudo. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Materia
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10704
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infectionCurciarello, RenataSteele, AlisonCooper, DianneMacdonald, Thomas T.Kruidenier, LaurenTakahiro, KudoGalectinsGastrointestinal tractCitrobacter rodentium infectionGalectin deficient miceMucosahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino UnidoFil: Steele, Alison. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino UnidoFil: Cooper, Dianne. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute; Reino UnidoFil: Macdonald, Thomas T.. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino UnidoFil: Kruidenier, Lauren. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino UnidoFil: Takahiro, Kudo. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino UnidoPublic Library Of Science2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10704Curciarello, Renata; Steele, Alison; Cooper, Dianne; Macdonald, Thomas T.; Kruidenier, Lauren; et al.; The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection; Public Library Of Science; Plos One; 9; 9; 9-2014; 1-8; e1079331932-6203enginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0107933info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171484/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:38:46Zoai:ri.conicet.gov.ar:11336/10704instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:38:47.138CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
title The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
spellingShingle The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
Curciarello, Renata
Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
title_short The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
title_full The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
title_fullStr The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
title_full_unstemmed The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
title_sort The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection
dc.creator.none.fl_str_mv Curciarello, Renata
Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author Curciarello, Renata
author_facet Curciarello, Renata
Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author_role author
author2 Steele, Alison
Cooper, Dianne
Macdonald, Thomas T.
Kruidenier, Lauren
Takahiro, Kudo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
topic Galectins
Gastrointestinal tract
Citrobacter rodentium infection
Galectin deficient mice
Mucosa
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
Fil: Curciarello, Renata. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Steele, Alison. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Cooper, Dianne. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. William Harvey Research Institute; Reino Unido
Fil: Macdonald, Thomas T.. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Kruidenier, Lauren. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
Fil: Takahiro, Kudo. Queen Mary University of London. Barts and the London School of Medicine and Dentistry. Blizard Institute; Reino Unido
description Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin- 3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10704
Curciarello, Renata; Steele, Alison; Cooper, Dianne; Macdonald, Thomas T.; Kruidenier, Lauren; et al.; The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection; Public Library Of Science; Plos One; 9; 9; 9-2014; 1-8; e107933
1932-6203
url http://hdl.handle.net/11336/10704
identifier_str_mv Curciarello, Renata; Steele, Alison; Cooper, Dianne; Macdonald, Thomas T.; Kruidenier, Lauren; et al.; The role of Galectin-1 and Galectin-3 in the mucosal immune response to Citrobacter rodentium infection; Public Library Of Science; Plos One; 9; 9; 9-2014; 1-8; e107933
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0107933
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107933
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171484/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Of Science
publisher.none.fl_str_mv Public Library Of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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