Prodigiosin: a promising biomolecule with many potential biomedical applications

Autores
Islan, Germán Abel; Rodenak-Kladniew, Boris; Noacco, Nehuen; Duran, Nelson; Castro, Guillermo Raúl
Año de publicación
2022
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Instituto de Investigaciones Bioquímicas de La Plata
Materia
Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/154604
Acceder
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repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Prodigiosin: a promising biomolecule with many potential biomedical applicationsIslan, Germán AbelRodenak-Kladniew, BorisNoacco, NehuenDuran, NelsonCastro, Guillermo RaúlBioquímicaCiencias MédicasProdigiosinSerratia marcescensProdigiosin productionProdigiosin biological activitiesAnticancerAntimicrobialAntifungalPigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.Centro de Investigación y Desarrollo en Fermentaciones IndustrialesInstituto de Investigaciones Bioquímicas de La Plata2022info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf4227–14258http://sedici.unlp.edu.ar/handle/10915/154604enginfo:eu-repo/semantics/altIdentifier/issn/2165-5979info:eu-repo/semantics/altIdentifier/issn/2165-5987info:eu-repo/semantics/altIdentifier/doi/10.1080/21655979.2022.2084498info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:40:04Zoai:sedici.unlp.edu.ar:10915/154604Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:40:04.525SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Prodigiosin: a promising biomolecule with many potential biomedical applications
title Prodigiosin: a promising biomolecule with many potential biomedical applications
spellingShingle Prodigiosin: a promising biomolecule with many potential biomedical applications
Islan, Germán Abel
Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
title_short Prodigiosin: a promising biomolecule with many potential biomedical applications
title_full Prodigiosin: a promising biomolecule with many potential biomedical applications
title_fullStr Prodigiosin: a promising biomolecule with many potential biomedical applications
title_full_unstemmed Prodigiosin: a promising biomolecule with many potential biomedical applications
title_sort Prodigiosin: a promising biomolecule with many potential biomedical applications
dc.creator.none.fl_str_mv Islan, Germán Abel
Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
author Islan, Germán Abel
author_facet Islan, Germán Abel
Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
author_role author
author2 Rodenak-Kladniew, Boris
Noacco, Nehuen
Duran, Nelson
Castro, Guillermo Raúl
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
topic Bioquímica
Ciencias Médicas
Prodigiosin
Serratia marcescens
Prodigiosin production
Prodigiosin biological activities
Anticancer
Antimicrobial
Antifungal
dc.description.none.fl_txt_mv Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.
Centro de Investigación y Desarrollo en Fermentaciones Industriales
Instituto de Investigaciones Bioquímicas de La Plata
description Pigments are among the most fascinating molecules found in nature and used by human civilizations since the prehistoric ages. Although most of the bio-dyes reported in the literature were discovered around the eighties, the necessity to explore novel compounds for new biological applications has made them resurface as potential alternatives. Prodigiosin (PG) is an alkaloid red bio-dye produced by diverse microorganisms and composed of a linear tripyrrole chemical structure. PG emerges as a really interesting tool since it shows a wide spectrum of biological activities, such as antibacterial, antifungal, algicidal, anti-Chagas, antiamoebic, antimalarial, anticancer, antiparasitic, antiviral, and/or immunosuppressive. However, PG vehiculation into different delivery systems has been proposed since possesses low bioavailability because of its high hydrophobic character (XLogP3-AA = 4.5). In the present review, the general aspects of the PG correlated with synthesis, production process, and biological activities are reported. Besides, some of the most relevant PG delivery systems described in the literature, as well as novel unexplored applications to potentiate its biological activity in biomedical applications, are proposed.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/154604
url http://sedici.unlp.edu.ar/handle/10915/154604
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2165-5979
info:eu-repo/semantics/altIdentifier/issn/2165-5987
info:eu-repo/semantics/altIdentifier/doi/10.1080/21655979.2022.2084498
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
4227–14258
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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