Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1
- Autores
- Cingolani, Horacio Eugenio; Pérez, Néstor Gustavo; Aiello, Ernesto Alejandro; Ennis, Irene Lucía; Garciarena, Carolina Denis; Villa Abrille, María Celeste; Dulce, Raúl Ariel; Caldiz, Claudia Irma; Yeves, Alejandra del Milagro; Correa, María Verónica; Nolly, Mariela Beatriz; Chiappe de Cingolani, Gladys Ethel
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.
Centro de Investigaciones Cardiovasculares - Materia
-
Ciencias Médicas
Cardiología - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
.jpg)
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/138480
Ver los metadatos del registro completo
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Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1Cingolani, Horacio EugenioPérez, Néstor GustavoAiello, Ernesto AlejandroEnnis, Irene LucíaGarciarena, Carolina DenisVilla Abrille, María CelesteDulce, Raúl ArielCaldiz, Claudia IrmaYeves, Alejandra del MilagroCorrea, María VerónicaNolly, Mariela BeatrizChiappe de Cingolani, Gladys EthelCiencias MédicasCardiologíaThe enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways.Centro de Investigaciones Cardiovasculares2008-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf7096-7114http://sedici.unlp.edu.ar/handle/10915/138480enginfo:eu-repo/semantics/altIdentifier/issn/2768-6698info:eu-repo/semantics/altIdentifier/doi/10.2741/3213info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:27:02Zoai:sedici.unlp.edu.ar:10915/138480Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:27:02.963SEDICI (UNLP) - Universidad Nacional de La Platafalse |
| dc.title.none.fl_str_mv |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| title |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| spellingShingle |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 Cingolani, Horacio Eugenio Ciencias Médicas Cardiología |
| title_short |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| title_full |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| title_fullStr |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| title_full_unstemmed |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| title_sort |
Early signals after stretch leading to cardiac hypertrophy : Key role of NHE-1 |
| dc.creator.none.fl_str_mv |
Cingolani, Horacio Eugenio Pérez, Néstor Gustavo Aiello, Ernesto Alejandro Ennis, Irene Lucía Garciarena, Carolina Denis Villa Abrille, María Celeste Dulce, Raúl Ariel Caldiz, Claudia Irma Yeves, Alejandra del Milagro Correa, María Verónica Nolly, Mariela Beatriz Chiappe de Cingolani, Gladys Ethel |
| author |
Cingolani, Horacio Eugenio |
| author_facet |
Cingolani, Horacio Eugenio Pérez, Néstor Gustavo Aiello, Ernesto Alejandro Ennis, Irene Lucía Garciarena, Carolina Denis Villa Abrille, María Celeste Dulce, Raúl Ariel Caldiz, Claudia Irma Yeves, Alejandra del Milagro Correa, María Verónica Nolly, Mariela Beatriz Chiappe de Cingolani, Gladys Ethel |
| author_role |
author |
| author2 |
Pérez, Néstor Gustavo Aiello, Ernesto Alejandro Ennis, Irene Lucía Garciarena, Carolina Denis Villa Abrille, María Celeste Dulce, Raúl Ariel Caldiz, Claudia Irma Yeves, Alejandra del Milagro Correa, María Verónica Nolly, Mariela Beatriz Chiappe de Cingolani, Gladys Ethel |
| author2_role |
author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Ciencias Médicas Cardiología |
| topic |
Ciencias Médicas Cardiología |
| dc.description.none.fl_txt_mv |
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways. Centro de Investigaciones Cardiovasculares |
| description |
The enhanced activity of the cardiac Na+/H+ exchanger (NHE-1) after myocardial stretch is considered a key step of the intracellular signaling pathway leading to the slow force response to stretch as well as an early signal for the development of cardiac hypertrophy. We propose that the chain of events triggered by stretch begins with the release of small amounts of Angiotensin II (Ang II)/endothelin (ET) and ends with the increase in intracellular Ca2+ concentration ([Ca2+]i) through the Na+/Ca2+ exchanger in reverse mode (NCXrev), which triggers cardiac hypertrophy by activation of widely recognized Ca2+-dependent intracellular signaling pathways. |
| publishDate |
2008 |
| dc.date.none.fl_str_mv |
2008-05-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://sedici.unlp.edu.ar/handle/10915/138480 |
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eng |
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eng |
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