The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies

Autores
Achilli, Alessandro; Perego, Ugo A.; Bravi, Claudio Marcelo; Coble, Michael D.; Kong, Qing Peng; Woodward, Scott R.; Salas, Antonio; Torroni, Antonio; Bandelt, Hans Jürgen
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrast with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
Instituto Multidisciplinario de Biología Celular
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Exactas
Ciencias Naturales
Native American haplogroups
mitochondrial DNA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/84190

id SEDICI_79efce9b057d3ece0d44fd9b34ee59a1
oai_identifier_str oai:sedici.unlp.edu.ar:10915/84190
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studiesAchilli, AlessandroPerego, Ugo A.Bravi, Claudio MarceloCoble, Michael D.Kong, Qing PengWoodward, Scott R.Salas, AntonioTorroni, AntonioBandelt, Hans JürgenCiencias ExactasCiencias NaturalesNative American haplogroupsmitochondrial DNAOnly a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrast with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.Instituto Multidisciplinario de Biología CelularFacultad de Ciencias Naturales y Museo2008info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/84190enginfo:eu-repo/semantics/altIdentifier/issn/1932-6203info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0001764info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:16:14Zoai:sedici.unlp.edu.ar:10915/84190Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:16:15.181SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
title The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
spellingShingle The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
Achilli, Alessandro
Ciencias Exactas
Ciencias Naturales
Native American haplogroups
mitochondrial DNA
title_short The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
title_full The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
title_fullStr The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
title_full_unstemmed The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
title_sort The phylogeny of the four pan-American MtDNA haplogroups: Implications for evolutionary and disease studies
dc.creator.none.fl_str_mv Achilli, Alessandro
Perego, Ugo A.
Bravi, Claudio Marcelo
Coble, Michael D.
Kong, Qing Peng
Woodward, Scott R.
Salas, Antonio
Torroni, Antonio
Bandelt, Hans Jürgen
author Achilli, Alessandro
author_facet Achilli, Alessandro
Perego, Ugo A.
Bravi, Claudio Marcelo
Coble, Michael D.
Kong, Qing Peng
Woodward, Scott R.
Salas, Antonio
Torroni, Antonio
Bandelt, Hans Jürgen
author_role author
author2 Perego, Ugo A.
Bravi, Claudio Marcelo
Coble, Michael D.
Kong, Qing Peng
Woodward, Scott R.
Salas, Antonio
Torroni, Antonio
Bandelt, Hans Jürgen
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Ciencias Naturales
Native American haplogroups
mitochondrial DNA
topic Ciencias Exactas
Ciencias Naturales
Native American haplogroups
mitochondrial DNA
dc.description.none.fl_txt_mv Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrast with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
Instituto Multidisciplinario de Biología Celular
Facultad de Ciencias Naturales y Museo
description Only a limited number of complete mitochondrial genome sequences belonging to Native American haplogroups were available until recently, which left America as the continent with the least of information about sequence variation of entire mitochondrial DNAs. In this study, a comprehensive overview of all available complete mitochondrial DNA (mtDNA) genomes of the four pan-American haplogroups A2, B2, C1, and D1 is provided by revising the information scattered throughout GenBank and the literature, and adding 14 novel mtDNA sequences. The phylogenies of haplogroups A2, B2, C1, and D1 reveal a large number of sub haplogroups but suggest that the ancestral Beringian population(s) contributed only six (successful) founder haplotypes to these haplogroups. The derived are overall starlike with coalescence times ranging from 18,000 to 21,000 years (with one exception) using the conventional calibration. The average of about 19,000 years somewhat contrast with the corresponding lower age of about 13,500 years that was recently proposed by employing a different calibration and estimation approach. Our estimate indicates a human entry and spread of the pan-American haplogroups into the Americas right after the peak of the Last Glacial Maximum and comfortably agrees with the undisputed ages of the earliest Paleoindians in South America. In addition, the phylogenetic approach also indicates that the pathogenic status proposed for various mtDNA mutations, which actually define branches of Native American haplogroups, was based on insufficient grounds.
publishDate 2008
dc.date.none.fl_str_mv 2008
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/84190
url http://sedici.unlp.edu.ar/handle/10915/84190
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1932-6203
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0001764
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1844616034793816064
score 13.070432