The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia

Autores
Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; Kashani, Baharak Hooshiar; Carossa, Valeria; Ekins, Jayne E.; Gómez Carballa, Alberto; Huber, Gabriela; Zimmermann, Bettina; Corach, Daniel; Babudri, Nora; Panara, Fausto; Myres, Natalie M.; Parson, Walther; Semino, Ornella; Salas, Antonio; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.
Fil: Perego, Ugo A.. Soreson Molecular Genealogy Foundation; Estados Unidos. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Angerhofer, Norman. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Pala, Maria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Olivieri, Anna. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Lancioni, Hovirag. Universita Di Perugia; Italia
Fil: Kashani, Baharak Hooshiar. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Carossa, Valeria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Ekins, Jayne E.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Gómez Carballa, Alberto. Universidad de Santiago de Compostela; España
Fil: Huber, Gabriela. Universidad de Innsbruck; Austria
Fil: Zimmermann, Bettina. Universidad de Innsbruck; Austria
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babudri, Nora. Universita Di Perugia; Italia
Fil: Panara, Fausto. Universita Di Perugia; Italia
Fil: Myres, Natalie M.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Parson, Walther. Universidad de Innsbruck; Austria
Fil: Semino, Ornella. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Salas, Antonio. Universidad de Santiago de Compostela; España
Fil: Woodward, Scott R.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Achilli, Alessandro. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia. Universita Di Perugia; Italia
Fil: Torroni, Antonio. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Materia
Pan-American mitochondrial DNA
Haplogroups
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14470
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/14470
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The initial peopling of the Americas: a growing number of founding mitochondrial genomes from BeringiaPerego, Ugo A.Angerhofer, NormanPala, MariaOlivieri, AnnaLancioni, HoviragKashani, Baharak HooshiarCarossa, ValeriaEkins, Jayne E.Gómez Carballa, AlbertoHuber, GabrielaZimmermann, BettinaCorach, DanielBabudri, NoraPanara, FaustoMyres, Natalie M.Parson, WaltherSemino, OrnellaSalas, AntonioWoodward, Scott R.Achilli, AlessandroTorroni, AntonioPan-American mitochondrial DNAHaplogroupshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.Fil: Perego, Ugo A.. Soreson Molecular Genealogy Foundation; Estados Unidos. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Angerhofer, Norman. Soreson Molecular Genealogy Foundation; Estados UnidosFil: Pala, Maria. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Olivieri, Anna. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Lancioni, Hovirag. Universita Di Perugia; ItaliaFil: Kashani, Baharak Hooshiar. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Carossa, Valeria. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Ekins, Jayne E.. Soreson Molecular Genealogy Foundation; Estados UnidosFil: Gómez Carballa, Alberto. Universidad de Santiago de Compostela; EspañaFil: Huber, Gabriela. Universidad de Innsbruck; AustriaFil: Zimmermann, Bettina. Universidad de Innsbruck; AustriaFil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Babudri, Nora. Universita Di Perugia; ItaliaFil: Panara, Fausto. Universita Di Perugia; ItaliaFil: Myres, Natalie M.. Soreson Molecular Genealogy Foundation; Estados UnidosFil: Parson, Walther. Universidad de Innsbruck; AustriaFil: Semino, Ornella. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaFil: Salas, Antonio. Universidad de Santiago de Compostela; EspañaFil: Woodward, Scott R.. Soreson Molecular Genealogy Foundation; Estados UnidosFil: Achilli, Alessandro. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia. Universita Di Perugia; ItaliaFil: Torroni, Antonio. Università di Pavia. Dipartimento di Genetica e Microbiologia; ItaliaCold Spring Harbor Lab Press2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14470Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; et al.; The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia; Cold Spring Harbor Lab Press; Genome Research; 20; 9; 9-2010; 1174-11791088-90511549-5469enginfo:eu-repo/semantics/altIdentifier/url/http://genome.cshlp.org/content/20/9/1174.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1101/gr.109231.110info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:59Zoai:ri.conicet.gov.ar:11336/14470instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:59.775CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
title The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
spellingShingle The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
Perego, Ugo A.
Pan-American mitochondrial DNA
Haplogroups
title_short The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
title_full The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
title_fullStr The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
title_full_unstemmed The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
title_sort The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia
dc.creator.none.fl_str_mv Perego, Ugo A.
Angerhofer, Norman
Pala, Maria
Olivieri, Anna
Lancioni, Hovirag
Kashani, Baharak Hooshiar
Carossa, Valeria
Ekins, Jayne E.
Gómez Carballa, Alberto
Huber, Gabriela
Zimmermann, Bettina
Corach, Daniel
Babudri, Nora
Panara, Fausto
Myres, Natalie M.
Parson, Walther
Semino, Ornella
Salas, Antonio
Woodward, Scott R.
Achilli, Alessandro
Torroni, Antonio
author Perego, Ugo A.
author_facet Perego, Ugo A.
Angerhofer, Norman
Pala, Maria
Olivieri, Anna
Lancioni, Hovirag
Kashani, Baharak Hooshiar
Carossa, Valeria
Ekins, Jayne E.
Gómez Carballa, Alberto
Huber, Gabriela
Zimmermann, Bettina
Corach, Daniel
Babudri, Nora
Panara, Fausto
Myres, Natalie M.
Parson, Walther
Semino, Ornella
Salas, Antonio
Woodward, Scott R.
Achilli, Alessandro
Torroni, Antonio
author_role author
author2 Angerhofer, Norman
Pala, Maria
Olivieri, Anna
Lancioni, Hovirag
Kashani, Baharak Hooshiar
Carossa, Valeria
Ekins, Jayne E.
Gómez Carballa, Alberto
Huber, Gabriela
Zimmermann, Bettina
Corach, Daniel
Babudri, Nora
Panara, Fausto
Myres, Natalie M.
Parson, Walther
Semino, Ornella
Salas, Antonio
Woodward, Scott R.
Achilli, Alessandro
Torroni, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pan-American mitochondrial DNA
Haplogroups
topic Pan-American mitochondrial DNA
Haplogroups
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.
Fil: Perego, Ugo A.. Soreson Molecular Genealogy Foundation; Estados Unidos. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Angerhofer, Norman. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Pala, Maria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Olivieri, Anna. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Lancioni, Hovirag. Universita Di Perugia; Italia
Fil: Kashani, Baharak Hooshiar. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Carossa, Valeria. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Ekins, Jayne E.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Gómez Carballa, Alberto. Universidad de Santiago de Compostela; España
Fil: Huber, Gabriela. Universidad de Innsbruck; Austria
Fil: Zimmermann, Bettina. Universidad de Innsbruck; Austria
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Babudri, Nora. Universita Di Perugia; Italia
Fil: Panara, Fausto. Universita Di Perugia; Italia
Fil: Myres, Natalie M.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Parson, Walther. Universidad de Innsbruck; Austria
Fil: Semino, Ornella. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
Fil: Salas, Antonio. Universidad de Santiago de Compostela; España
Fil: Woodward, Scott R.. Soreson Molecular Genealogy Foundation; Estados Unidos
Fil: Achilli, Alessandro. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia. Universita Di Perugia; Italia
Fil: Torroni, Antonio. Università di Pavia. Dipartimento di Genetica e Microbiologia; Italia
description Pan-American mitochondrial DNA (mtDNA) haplogroup C1 has been recently subdivided into three branches, two of which (C1b and C1c) are characterized by ages and geographical distributions that are indicative of an early arrival from Beringia with Paleo-Indians. In contrast, the estimated ages of C1d—the third subset of C1—looked too young to fit the above scenario. To define the origin of this enigmatic C1 branch, we completely sequenced 63 C1d mitochondrial genomes from a wide range of geographically diverse, mixed, and indigenous American populations. The revised phylogeny not only brings the age of C1d within the range of that of its two sister clades, but reveals that there were two C1d founder genomes for Paleo-Indians. Thus, the recognized maternal founding lineages of Native Americans are at least 15, indicating that the overall number of Beringian or Asian founder mitochondrial genomes will probably increase extensively when all Native American haplogroups reach the same level of phylogenetic and genomic resolution as obtained here for C1d.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14470
Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; et al.; The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia; Cold Spring Harbor Lab Press; Genome Research; 20; 9; 9-2010; 1174-1179
1088-9051
1549-5469
url http://hdl.handle.net/11336/14470
identifier_str_mv Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; et al.; The initial peopling of the Americas: a growing number of founding mitochondrial genomes from Beringia; Cold Spring Harbor Lab Press; Genome Research; 20; 9; 9-2010; 1174-1179
1088-9051
1549-5469
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://genome.cshlp.org/content/20/9/1174.full
info:eu-repo/semantics/altIdentifier/doi/10.1101/gr.109231.110
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cold Spring Harbor Lab Press
publisher.none.fl_str_mv Cold Spring Harbor Lab Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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