A historical legacy of antibiotic utilization on bacterial seed banks in sediments

Autores
Madueño, Laura; Paul, Christophe; Junier, Thomas; Bayrychenko, Zhanna; Filippidou, Sevasti; Beck, Karin; Greub, Gilbert; Bürgmann, Helmut; Junier, Pilar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
Departamento de Ciencias Biológicas
Materia
Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/104623
Acceder
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network_name_str SEDICI (UNLP)
spelling A historical legacy of antibiotic utilization on bacterial seed banks in sedimentsMadueño, LauraPaul, ChristopheJunier, ThomasBayrychenko, ZhannaFilippidou, SevastiBeck, KarinGreub, GilbertBürgmann, HelmutJunier, PilarCiencias MédicasCiencias ExactasAntibiotic resistanceClostridiaEndosporesSedimentsSeed bankSulfonamideTetracyclineThe introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (<i>tet</i>(W)) and sulfonamide (<i>sul</i>1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of <i>tet</i>(W) and a steady increase in sul1. The abrupt change in <i>tet</i>(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum <i>Firmicutes</i>. In contrast, the relative abundance of <i>sul</i>1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting <i>sul</i>1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.Departamento de Ciencias Biológicas2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf2-19http://sedici.unlp.edu.ar/handle/10915/104623enginfo:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/93894info:eu-repo/semantics/altIdentifier/issn/2167-8359info:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.4197info:eu-repo/semantics/altIdentifier/hdl/11336/93894info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:22:43Zoai:sedici.unlp.edu.ar:10915/104623Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:22:44.316SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title A historical legacy of antibiotic utilization on bacterial seed banks in sediments
spellingShingle A historical legacy of antibiotic utilization on bacterial seed banks in sediments
Madueño, Laura
Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
title_short A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_fullStr A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full_unstemmed A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_sort A historical legacy of antibiotic utilization on bacterial seed banks in sediments
dc.creator.none.fl_str_mv Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author Madueño, Laura
author_facet Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author_role author
author2 Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
topic Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
dc.description.none.fl_txt_mv The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (<i>tet</i>(W)) and sulfonamide (<i>sul</i>1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of <i>tet</i>(W) and a steady increase in sul1. The abrupt change in <i>tet</i>(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum <i>Firmicutes</i>. In contrast, the relative abundance of <i>sul</i>1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting <i>sul</i>1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
Departamento de Ciencias Biológicas
description The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (<i>tet</i>(W)) and sulfonamide (<i>sul</i>1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of <i>tet</i>(W) and a steady increase in sul1. The abrupt change in <i>tet</i>(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum <i>Firmicutes</i>. In contrast, the relative abundance of <i>sul</i>1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting <i>sul</i>1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/104623
url http://sedici.unlp.edu.ar/handle/10915/104623
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://hdl.handle.net/11336/93894
info:eu-repo/semantics/altIdentifier/issn/2167-8359
info:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.4197
info:eu-repo/semantics/altIdentifier/hdl/11336/93894
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
2-19
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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