A historical legacy of antibiotic utilization on bacterial seed banks in sediments

Autores
Madueño, Laura; Paul, Christophe; Junier, Thomas; Bayrychenko, Zhanna; Filippidou, Sevasti; Beck, Karin; Greub, Gilbert; Bürgmann, Helmut; Junier, Pilar
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
Fil: Madueño, Laura. Universite de Neuchatel; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Paul, Christophe. Universite de Neuchatel; Suiza
Fil: Junier, Thomas. Swiss Institute of Bioinformatics; Suiza
Fil: Bayrychenko, Zhanna. Universite de Neuchatel; Suiza
Fil: Filippidou, Sevasti. Universite de Neuchatel; Suiza
Fil: Beck, Karin. Swiss Federal Institute of Aquatic Science and Technology; Suiza
Fil: Greub, Gilbert. Universite de Lausanne; Suiza
Fil: Bürgmann, Helmut. Swiss Federal Institute of Aquatic Science and Technology; Suiza
Fil: Junier, Pilar. Universite de Neuchatel; Suiza
Materia
ANTIBIOTIC RESISTANCE
CLOSTRIDIA
ENDOSPORES
SEDIMENTS
SEED BANK
SULFONAMIDE
TETRACYCLINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/93894
Acceder
id CONICETDig_99df38f73d43228c7b0f59285141628c
oai_identifier_str oai:ri.conicet.gov.ar:11336/93894
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A historical legacy of antibiotic utilization on bacterial seed banks in sedimentsMadueño, LauraPaul, ChristopheJunier, ThomasBayrychenko, ZhannaFilippidou, SevastiBeck, KarinGreub, GilbertBürgmann, HelmutJunier, PilarANTIBIOTIC RESISTANCECLOSTRIDIAENDOSPORESSEDIMENTSSEED BANKSULFONAMIDETETRACYCLINEhttps://purl.org/becyt/ford/1.5https://purl.org/becyt/ford/1The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.Fil: Madueño, Laura. Universite de Neuchatel; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; ArgentinaFil: Paul, Christophe. Universite de Neuchatel; SuizaFil: Junier, Thomas. Swiss Institute of Bioinformatics; SuizaFil: Bayrychenko, Zhanna. Universite de Neuchatel; SuizaFil: Filippidou, Sevasti. Universite de Neuchatel; SuizaFil: Beck, Karin. Swiss Federal Institute of Aquatic Science and Technology; SuizaFil: Greub, Gilbert. Universite de Lausanne; SuizaFil: Bürgmann, Helmut. Swiss Federal Institute of Aquatic Science and Technology; SuizaFil: Junier, Pilar. Universite de Neuchatel; SuizaPeerJ2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/93894Madueño, Laura; Paul, Christophe; Junier, Thomas; Bayrychenko, Zhanna; Filippidou, Sevasti; et al.; A historical legacy of antibiotic utilization on bacterial seed banks in sediments; PeerJ ; PeerJ; 2018; 1; 1-2018; 2-192167-8359CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.4197info:eu-repo/semantics/altIdentifier/url/https://peerj.com/articles/4197/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:41Zoai:ri.conicet.gov.ar:11336/93894instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:42.159CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title A historical legacy of antibiotic utilization on bacterial seed banks in sediments
spellingShingle A historical legacy of antibiotic utilization on bacterial seed banks in sediments
Madueño, Laura
ANTIBIOTIC RESISTANCE
CLOSTRIDIA
ENDOSPORES
SEDIMENTS
SEED BANK
SULFONAMIDE
TETRACYCLINE
title_short A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_fullStr A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full_unstemmed A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_sort A historical legacy of antibiotic utilization on bacterial seed banks in sediments
dc.creator.none.fl_str_mv Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author Madueño, Laura
author_facet Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author_role author
author2 Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIBIOTIC RESISTANCE
CLOSTRIDIA
ENDOSPORES
SEDIMENTS
SEED BANK
SULFONAMIDE
TETRACYCLINE
topic ANTIBIOTIC RESISTANCE
CLOSTRIDIA
ENDOSPORES
SEDIMENTS
SEED BANK
SULFONAMIDE
TETRACYCLINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.5
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
Fil: Madueño, Laura. Universite de Neuchatel; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina
Fil: Paul, Christophe. Universite de Neuchatel; Suiza
Fil: Junier, Thomas. Swiss Institute of Bioinformatics; Suiza
Fil: Bayrychenko, Zhanna. Universite de Neuchatel; Suiza
Fil: Filippidou, Sevasti. Universite de Neuchatel; Suiza
Fil: Beck, Karin. Swiss Federal Institute of Aquatic Science and Technology; Suiza
Fil: Greub, Gilbert. Universite de Lausanne; Suiza
Fil: Bürgmann, Helmut. Swiss Federal Institute of Aquatic Science and Technology; Suiza
Fil: Junier, Pilar. Universite de Neuchatel; Suiza
description The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (tet(W)) and sulfonamide (sul1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of tet(W) and a steady increase in sul1. The abrupt change in tet(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum Firmicutes. In contrast, the relative abundance of sul1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting sul1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/93894
Madueño, Laura; Paul, Christophe; Junier, Thomas; Bayrychenko, Zhanna; Filippidou, Sevasti; et al.; A historical legacy of antibiotic utilization on bacterial seed banks in sediments; PeerJ ; PeerJ; 2018; 1; 1-2018; 2-19
2167-8359
CONICET Digital
CONICET
url http://hdl.handle.net/11336/93894
identifier_str_mv Madueño, Laura; Paul, Christophe; Junier, Thomas; Bayrychenko, Zhanna; Filippidou, Sevasti; et al.; A historical legacy of antibiotic utilization on bacterial seed banks in sediments; PeerJ ; PeerJ; 2018; 1; 1-2018; 2-19
2167-8359
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.7717/peerj.4197
info:eu-repo/semantics/altIdentifier/url/https://peerj.com/articles/4197/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv PeerJ
publisher.none.fl_str_mv PeerJ
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614448386408448
score 13.070432

Publicaciones similares