Potential role of the intestinal microbiota of the mother in neonatal immune education

Autores
Donnet Hughes, Anne; Pérez, Pablo Fernando; Doré, Joël; Leclerc, Marion; Levenez, Florence; Benyacoub, Jalil; Serrant, Patrick; Segura Roggero, Iris; Schiffrin, Eduardo J.
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/82485

id SEDICI_5ce1447267388b1d42d11add12b20026
oai_identifier_str oai:sedici.unlp.edu.ar:10915/82485
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Potential role of the intestinal microbiota of the mother in neonatal immune educationDonnet Hughes, AnnePérez, Pablo FernandoDoré, JoëlLeclerc, MarionLevenez, FlorenceBenyacoub, JalilSerrant, PatrickSegura Roggero, IrisSchiffrin, Eduardo J.Ciencias ExactasBacterial translocationBreast milkLactationMicrobiotaNeonatal immunityPregnancyMucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.Facultad de Ciencias Exactas2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf407-415http://sedici.unlp.edu.ar/handle/10915/82485enginfo:eu-repo/semantics/altIdentifier/issn/00296651info:eu-repo/semantics/altIdentifier/doi/10.1017/S0029665110001898info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:31Zoai:sedici.unlp.edu.ar:10915/82485Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:31.278SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Potential role of the intestinal microbiota of the mother in neonatal immune education
title Potential role of the intestinal microbiota of the mother in neonatal immune education
spellingShingle Potential role of the intestinal microbiota of the mother in neonatal immune education
Donnet Hughes, Anne
Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
title_short Potential role of the intestinal microbiota of the mother in neonatal immune education
title_full Potential role of the intestinal microbiota of the mother in neonatal immune education
title_fullStr Potential role of the intestinal microbiota of the mother in neonatal immune education
title_full_unstemmed Potential role of the intestinal microbiota of the mother in neonatal immune education
title_sort Potential role of the intestinal microbiota of the mother in neonatal immune education
dc.creator.none.fl_str_mv Donnet Hughes, Anne
Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
author Donnet Hughes, Anne
author_facet Donnet Hughes, Anne
Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
author_role author
author2 Pérez, Pablo Fernando
Doré, Joël
Leclerc, Marion
Levenez, Florence
Benyacoub, Jalil
Serrant, Patrick
Segura Roggero, Iris
Schiffrin, Eduardo J.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
topic Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy
dc.description.none.fl_txt_mv Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.
Facultad de Ciencias Exactas
description Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/82485
url http://sedici.unlp.edu.ar/handle/10915/82485
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/00296651
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0029665110001898
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
407-415
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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