Potential role of the intestinal microbiota of the mother in neonatal immune education
- Autores
- Donnet Hughes, Anne; Pérez, Pablo Fernando; Doré, Joël; Leclerc, Marion; Levenez, Florence; Benyacoub, Jalil; Serrant, Patrick; Segura Roggero, Iris; Schiffrin, Eduardo J.
- Año de publicación
- 2010
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.
Facultad de Ciencias Exactas - Materia
-
Ciencias Exactas
Bacterial translocation
Breast milk
Lactation
Microbiota
Neonatal immunity
Pregnancy - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/82485
Ver los metadatos del registro completo
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Potential role of the intestinal microbiota of the mother in neonatal immune educationDonnet Hughes, AnnePérez, Pablo FernandoDoré, JoëlLeclerc, MarionLevenez, FlorenceBenyacoub, JalilSerrant, PatrickSegura Roggero, IrisSchiffrin, Eduardo J.Ciencias ExactasBacterial translocationBreast milkLactationMicrobiotaNeonatal immunityPregnancyMucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns.Facultad de Ciencias Exactas2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf407-415http://sedici.unlp.edu.ar/handle/10915/82485enginfo:eu-repo/semantics/altIdentifier/issn/00296651info:eu-repo/semantics/altIdentifier/doi/10.1017/S0029665110001898info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:15:31Zoai:sedici.unlp.edu.ar:10915/82485Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:15:31.278SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
title |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
spellingShingle |
Potential role of the intestinal microbiota of the mother in neonatal immune education Donnet Hughes, Anne Ciencias Exactas Bacterial translocation Breast milk Lactation Microbiota Neonatal immunity Pregnancy |
title_short |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
title_full |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
title_fullStr |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
title_full_unstemmed |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
title_sort |
Potential role of the intestinal microbiota of the mother in neonatal immune education |
dc.creator.none.fl_str_mv |
Donnet Hughes, Anne Pérez, Pablo Fernando Doré, Joël Leclerc, Marion Levenez, Florence Benyacoub, Jalil Serrant, Patrick Segura Roggero, Iris Schiffrin, Eduardo J. |
author |
Donnet Hughes, Anne |
author_facet |
Donnet Hughes, Anne Pérez, Pablo Fernando Doré, Joël Leclerc, Marion Levenez, Florence Benyacoub, Jalil Serrant, Patrick Segura Roggero, Iris Schiffrin, Eduardo J. |
author_role |
author |
author2 |
Pérez, Pablo Fernando Doré, Joël Leclerc, Marion Levenez, Florence Benyacoub, Jalil Serrant, Patrick Segura Roggero, Iris Schiffrin, Eduardo J. |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas Bacterial translocation Breast milk Lactation Microbiota Neonatal immunity Pregnancy |
topic |
Ciencias Exactas Bacterial translocation Breast milk Lactation Microbiota Neonatal immunity Pregnancy |
dc.description.none.fl_txt_mv |
Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns. Facultad de Ciencias Exactas |
description |
Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/82485 |
url |
http://sedici.unlp.edu.ar/handle/10915/82485 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/issn/00296651 info:eu-repo/semantics/altIdentifier/doi/10.1017/S0029665110001898 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf 407-415 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
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