Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation

Autores
Conrad, Melanie L.; Freitag, Nancy; Diessler, Mónica Elizabeth; Hernández, Rocío; Barrientos, Gabriela; Rose, Matthias; Casas, Luciano Agustín; Barbeito, Claudio Gustavo; Blois, Sandra M.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/86265
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/86265
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial PlacentationConrad, Melanie L.Freitag, NancyDiessler, Mónica ElizabethHernández, RocíoBarrientos, GabrielaRose, MatthiasCasas, Luciano AgustínBarbeito, Claudio GustavoBlois, Sandra M.Ciencias VeterinariasCanineendotheliochorialfelinegalectinsplacentapregnancyProblem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.Facultad de Ciencias Veterinarias2016info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf317-325http://sedici.unlp.edu.ar/handle/10915/86265enginfo:eu-repo/semantics/altIdentifier/issn/1046-7408info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12452info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:49:07Zoai:sedici.unlp.edu.ar:10915/86265Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:49:07.871SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
spellingShingle Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
Conrad, Melanie L.
Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
title_short Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_full Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_fullStr Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_full_unstemmed Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
title_sort Differential Spatiotemporal Patterns of Galectin Expression are a Hallmark of Endotheliochorial Placentation
dc.creator.none.fl_str_mv Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
author Conrad, Melanie L.
author_facet Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
author_role author
author2 Freitag, Nancy
Diessler, Mónica Elizabeth
Hernández, Rocío
Barrientos, Gabriela
Rose, Matthias
Casas, Luciano Agustín
Barbeito, Claudio Gustavo
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
topic Ciencias Veterinarias
Canine
endotheliochorial
feline
galectins
placenta
pregnancy
dc.description.none.fl_txt_mv Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
Facultad de Ciencias Veterinarias
description Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/review
info:eu-repo/semantics/publishedVersion
Revision
http://purl.org/coar/resource_type/c_dcae04bc
info:ar-repo/semantics/resenaArticulo
format review
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/86265
url http://sedici.unlp.edu.ar/handle/10915/86265
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1046-7408
info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12452
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
317-325
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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