Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation

Autores
Conrad, Melanie L.; Freitag, Nancy; Diessler, Mónica Elizabeth; Hernandez, Rocío Belén; Barrientos, Gabriela Laura; Rose, Matthias; Casas, Luciano A.; Barbeito, Claudio Gustavo; Blois, Sandra M.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania
Fil: Diessler, Mónica Elizabeth. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Hernandez, Rocío Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania
Fil: Casas, Luciano A.. Clínica Veterinaria Berizoo; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania
Materia
CANINE
ENDOTHELIOCHORIAL
FELINE
GALECTINS
PLACENTA
PREGNANCY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/180123
Acceder
id CONICETDig_2af75fec5ec01ca6441d91b257ffdbe1
oai_identifier_str oai:ri.conicet.gov.ar:11336/180123
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentationConrad, Melanie L.Freitag, NancyDiessler, Mónica ElizabethHernandez, Rocío BelénBarrientos, Gabriela LauraRose, MatthiasCasas, Luciano A.Barbeito, Claudio GustavoBlois, Sandra M.CANINEENDOTHELIOCHORIALFELINEGALECTINSPLACENTAPREGNANCYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; AlemaniaFil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; AlemaniaFil: Diessler, Mónica Elizabeth. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; ArgentinaFil: Hernandez, Rocío Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; ArgentinaFil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; AlemaniaFil: Rose, Matthias. Charité-Universitätsmedizin Berlin; AlemaniaFil: Casas, Luciano A.. Clínica Veterinaria Berizoo; ArgentinaFil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; ArgentinaFil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; AlemaniaWiley Blackwell Publishing, Inc2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/180123Conrad, Melanie L.; Freitag, Nancy; Diessler, Mónica Elizabeth; Hernandez, Rocío Belén; Barrientos, Gabriela Laura; et al.; Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 75; 3; 11-2015; 317-3251046-7408CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/aji.12452info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12452info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:49Zoai:ri.conicet.gov.ar:11336/180123instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:50.099CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
title Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
spellingShingle Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
Conrad, Melanie L.
CANINE
ENDOTHELIOCHORIAL
FELINE
GALECTINS
PLACENTA
PREGNANCY
title_short Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
title_full Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
title_fullStr Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
title_full_unstemmed Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
title_sort Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation
dc.creator.none.fl_str_mv Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernandez, Rocío Belén
Barrientos, Gabriela Laura
Rose, Matthias
Casas, Luciano A.
Barbeito, Claudio Gustavo
Blois, Sandra M.
author Conrad, Melanie L.
author_facet Conrad, Melanie L.
Freitag, Nancy
Diessler, Mónica Elizabeth
Hernandez, Rocío Belén
Barrientos, Gabriela Laura
Rose, Matthias
Casas, Luciano A.
Barbeito, Claudio Gustavo
Blois, Sandra M.
author_role author
author2 Freitag, Nancy
Diessler, Mónica Elizabeth
Hernandez, Rocío Belén
Barrientos, Gabriela Laura
Rose, Matthias
Casas, Luciano A.
Barbeito, Claudio Gustavo
Blois, Sandra M.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANINE
ENDOTHELIOCHORIAL
FELINE
GALECTINS
PLACENTA
PREGNANCY
topic CANINE
ENDOTHELIOCHORIAL
FELINE
GALECTINS
PLACENTA
PREGNANCY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
Fil: Conrad, Melanie L.. Charité-Universitätsmedizin Berlin; Alemania
Fil: Freitag, Nancy. Charité-Universitätsmedizin Berlin; Alemania
Fil: Diessler, Mónica Elizabeth. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Hernandez, Rocío Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Barrientos, Gabriela Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Charité-Universitätsmedizin Berlin; Alemania
Fil: Rose, Matthias. Charité-Universitätsmedizin Berlin; Alemania
Fil: Casas, Luciano A.. Clínica Veterinaria Berizoo; Argentina
Fil: Barbeito, Claudio Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina
Fil: Blois, Sandra M.. Charité-Universitätsmedizin Berlin; Alemania
description Problem: Galectins influence the progress of pregnancy by regulating key processes associated with embryo-maternal cross talk, including angiogenesis and placentation. Galectin family members exert multiple roles in the context of hemochorial and epitheliochorial placentation; however, the galectin prolife in endotheliochorial placenta remains to be investigated. Method of study: Here, we used immunohistochemistry to analyze galectin (gal)-1, gal-3 and gal-9 expression during early and late endotheliochorial placentation in two different species (dogs and cats). Results: We found that during early feline gestation, all three galectin members were more strongly expressed on trophoblast and maternal vessels compared to the decidua. This was accompanied by an overall decrease of gal-1, gal-3 and gal-9 expressions in late feline gestation. In canine early pregnancy, we observed that gal-1 and gal-9 were expressed strongly in cytotrophoblast (CTB) cells compared to gal-3, and no galectin expression was observed in syncytiotrophoblast (STB) cells. Progression of canine gestation was accompanied by increased gal-1 and gal-3 expressions on STB cells, whereas gal-9 expression remained similar in CTB and STB. Conclusion: These data suggest that both the maternal and fetal compartments are characterized by a spatiotemporal regulation of galectin expression during endotheliochorial placentation. This strongly suggests the involvement of the galectin family in important developmental processes during gestation including immunemodulation, trophoblast invasion and angiogenesis. A conserved functional role for galectins during mammalian placental development emerges from these studies.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/180123
Conrad, Melanie L.; Freitag, Nancy; Diessler, Mónica Elizabeth; Hernandez, Rocío Belén; Barrientos, Gabriela Laura; et al.; Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 75; 3; 11-2015; 317-325
1046-7408
CONICET Digital
CONICET
url http://hdl.handle.net/11336/180123
identifier_str_mv Conrad, Melanie L.; Freitag, Nancy; Diessler, Mónica Elizabeth; Hernandez, Rocío Belén; Barrientos, Gabriela Laura; et al.; Differential spatiotemporal patterns of galectin expression are a hallmark of endotheliochorial placentation; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 75; 3; 11-2015; 317-325
1046-7408
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/aji.12452
info:eu-repo/semantics/altIdentifier/doi/10.1111/aji.12452
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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