Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release

Autores
Cortizo, María Cecilia; Fernández Lorenzo de Mele, Mónica Alicia; Cortizo, Ana María
Año de publicación
2004
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/71077

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spelling Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion ReleaseCortizo, María CeciliaFernández Lorenzo de Mele, Mónica AliciaCortizo, Ana MaríaCiencias Exactasbiocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion releaseMineralesMetalesIons released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.Facultad de Ciencias Exactas2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/71077enginfo:eu-repo/semantics/altIdentifier/url/https://digital.cic.gba.gob.ar/handle/11746/4513info:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:11:29Zoai:sedici.unlp.edu.ar:10915/71077Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:11:29.652SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
spellingShingle Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
Cortizo, María Cecilia
Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
title_short Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_full Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_fullStr Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_full_unstemmed Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
title_sort Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
dc.creator.none.fl_str_mv Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
author Cortizo, María Cecilia
author_facet Cortizo, María Cecilia
Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
author_role author
author2 Fernández Lorenzo de Mele, Mónica Alicia
Cortizo, Ana María
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
topic Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales
dc.description.none.fl_txt_mv Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.
Facultad de Ciencias Exactas
description Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.
publishDate 2004
dc.date.none.fl_str_mv 2004
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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language eng
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info:eu-repo/semantics/altIdentifier/issn/0163-4984
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
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