Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release
- Autores
- Cortizo, María Cecilia; Fernández Lorenzo de Mele, Mónica Alicia; Cortizo, Ana María
- Año de publicación
- 2004
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.
Facultad de Ciencias Exactas - Materia
-
Ciencias Exactas
biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release
Minerales
Metales - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/71077
Ver los metadatos del registro completo
id |
SEDICI_59edbc5293927b2a264a5c948ceb555d |
---|---|
oai_identifier_str |
oai:sedici.unlp.edu.ar:10915/71077 |
network_acronym_str |
SEDICI |
repository_id_str |
1329 |
network_name_str |
SEDICI (UNLP) |
spelling |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion ReleaseCortizo, María CeciliaFernández Lorenzo de Mele, Mónica AliciaCortizo, Ana MaríaCiencias Exactasbiocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion releaseMineralesMetalesIons released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media.Facultad de Ciencias Exactas2004info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/71077enginfo:eu-repo/semantics/altIdentifier/url/https://digital.cic.gba.gob.ar/handle/11746/4513info:eu-repo/semantics/altIdentifier/issn/0163-4984info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:11:29Zoai:sedici.unlp.edu.ar:10915/71077Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:11:29.652SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
title |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
spellingShingle |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release Cortizo, María Cecilia Ciencias Exactas biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release Minerales Metales |
title_short |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
title_full |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
title_fullStr |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
title_full_unstemmed |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
title_sort |
Metallic Dental Material Biocompatibility in Osteoblastlike Cells : Correlation with Metal Ion Release |
dc.creator.none.fl_str_mv |
Cortizo, María Cecilia Fernández Lorenzo de Mele, Mónica Alicia Cortizo, Ana María |
author |
Cortizo, María Cecilia |
author_facet |
Cortizo, María Cecilia Fernández Lorenzo de Mele, Mónica Alicia Cortizo, Ana María |
author_role |
author |
author2 |
Fernández Lorenzo de Mele, Mónica Alicia Cortizo, Ana María |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Exactas biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release Minerales Metales |
topic |
Ciencias Exactas biocompatibility, metallic dental materials, osteoblasts | cytotoxicity, atomic spectroscopy, corrosion, metal ion release Minerales Metales |
dc.description.none.fl_txt_mv |
Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media. Facultad de Ciencias Exactas |
description |
Ions released from metallic dental materials used in orthodontic appliances could induce undesirable effects on cells and tissues. This study evaluates the biocompatibility of two of the most labile components of metallic dental alloys on osteoblastlike cells. The influence of protein and ions on metal dissolution properties is also investigated using different electrolyte solutions. Morphological alterations, cell growth, and differentiation of osteoblasts were assessed after exposure to pure metals (Ag, Cu, Pd, Au) and Ni–Ti alloy and correlated with the kinetic of elements released into the culture media. Results showed that Cu and Ag were the most cytotoxic elements and the other metals were biocompatible with the osteoblasts. The parameters of biocompatibility were correlated with the levels of ions detected into the culture media. Metal ions induced cell death through early mitosis arrest, apoptotic phenomena, and necrotic processes. Voltamograms showed that anions and proteins interfered in the corrosion process. Fetal bovine serum (FBS) strongly affected the electrochemical process, increasing the oxidation rate of the metals. In conclusion, copper and silver ions showed a time-dependent low biocompatibility, which correlated with the concentration of released ions. The dissolution of the metallic materials was dependent on the composition of the simulated biological media. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Articulo http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/71077 |
url |
http://sedici.unlp.edu.ar/handle/10915/71077 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://digital.cic.gba.gob.ar/handle/11746/4513 info:eu-repo/semantics/altIdentifier/issn/0163-4984 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:SEDICI (UNLP) instname:Universidad Nacional de La Plata instacron:UNLP |
reponame_str |
SEDICI (UNLP) |
collection |
SEDICI (UNLP) |
instname_str |
Universidad Nacional de La Plata |
instacron_str |
UNLP |
institution |
UNLP |
repository.name.fl_str_mv |
SEDICI (UNLP) - Universidad Nacional de La Plata |
repository.mail.fl_str_mv |
alira@sedici.unlp.edu.ar |
_version_ |
1844615984397156352 |
score |
13.070432 |