A mathematical model of receptive field reorganization following stroke

Autores
Einarsdottir, Hildur; Montani, Fernando Fabián; Schultz, Simon R
Año de publicación
2007
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue.
Facultad de Ciencias Exactas
Materia
Física
Ingeniería
Insufficient blood transport to neurons in the brain
Stroke
gamma-aminobutyric acid
Recovery receptive field plasticity.
damaged tissue
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/160201
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/160201
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling A mathematical model of receptive field reorganization following strokeEinarsdottir, HildurMontani, Fernando FabiánSchultz, Simon RFísicaIngenieríaInsufficient blood transport to neurons in the brainStrokegamma-aminobutyric acidRecovery receptive field plasticity.damaged tissueInsufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue.Facultad de Ciencias Exactas2007-07info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionObjeto de conferenciahttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/160201enginfo:eu-repo/semantics/altIdentifier/issn/2161-9476info:eu-repo/semantics/altIdentifier/doi/10.1109/DEVLRN.2007.4354027info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:41:56Zoai:sedici.unlp.edu.ar:10915/160201Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:41:56.616SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv A mathematical model of receptive field reorganization following stroke
title A mathematical model of receptive field reorganization following stroke
spellingShingle A mathematical model of receptive field reorganization following stroke
Einarsdottir, Hildur
Física
Ingeniería
Insufficient blood transport to neurons in the brain
Stroke
gamma-aminobutyric acid
Recovery receptive field plasticity.
damaged tissue
title_short A mathematical model of receptive field reorganization following stroke
title_full A mathematical model of receptive field reorganization following stroke
title_fullStr A mathematical model of receptive field reorganization following stroke
title_full_unstemmed A mathematical model of receptive field reorganization following stroke
title_sort A mathematical model of receptive field reorganization following stroke
dc.creator.none.fl_str_mv Einarsdottir, Hildur
Montani, Fernando Fabián
Schultz, Simon R
author Einarsdottir, Hildur
author_facet Einarsdottir, Hildur
Montani, Fernando Fabián
Schultz, Simon R
author_role author
author2 Montani, Fernando Fabián
Schultz, Simon R
author2_role author
author
dc.subject.none.fl_str_mv Física
Ingeniería
Insufficient blood transport to neurons in the brain
Stroke
gamma-aminobutyric acid
Recovery receptive field plasticity.
damaged tissue
topic Física
Ingeniería
Insufficient blood transport to neurons in the brain
Stroke
gamma-aminobutyric acid
Recovery receptive field plasticity.
damaged tissue
dc.description.none.fl_txt_mv Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue.
Facultad de Ciencias Exactas
description Insufficient blood transport to neurons in the brain due to blocked or ruptured blood vessels (stroke) can lead to damage or death of cells, causing functional impairment. Intact neurons surrounding a stroke-like lesion have been shown to adapt to the damage by expanding their sensory receptive fields in the direction towards the lesion, thereby restoring information processing capacity within the cortex. We developed model of the effect of focal ischaemia on the performance of a neuronal population code, in order to study physiological parameters that could be influenced to enhance recovery from stroke. Our findings show that recovery of the accuracy of the population code is optimal by a specific amount of receptive field plasticity. This plasticity may be influenced by changing the level of gamma-aminobutyric acid (GABA-ergic) inhibition in the areas surrounding the damaged tissue.
publishDate 2007
dc.date.none.fl_str_mv 2007-07
dc.type.none.fl_str_mv info:eu-repo/semantics/conferenceObject
info:eu-repo/semantics/publishedVersion
Objeto de conferencia
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
format conferenceObject
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/160201
url http://sedici.unlp.edu.ar/handle/10915/160201
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2161-9476
info:eu-repo/semantics/altIdentifier/doi/10.1109/DEVLRN.2007.4354027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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