Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions

Autores
Buldain, Daniel Cornelio; Gortari Castillo, Lihuel; Marchetti, María Laura; Julca Lozano, Karen Geraldine; Bandoni, Arnaldo L.; Mestorino, Olga Nora
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Essential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models are useful in describing the growth, survival, and inactivation of microorganisms against antimicrobials. We evaluated the antimicrobial activity of Melaleuca armillaris EO obtained from plants placed in the province of Buenos Aires (Argentina) against Staphylococcus aureus. The minimum inhibitory and bactericidal concentrations were close and decreased, slightly acidifying the medium from pH 7.4 to 6.5 and 5.0. This result was also evidenced by applying a sigmoid model, where the time and EO concentration necessaries to achieve 50% of the maximum effect decreased when the medium was acidified. Moreover, at pH 7.4, applying the Gompertz model, we found that subinhibitory concentrations of EO decreased the growth rate and the maximum population density and increased the latency period concerning the control. Additionally, we established physicochemical parameters for quality control and standardization of M. armillaris EO. Mathematical modeling allowed us to estimate key parameters in the behavior of S. aureus and Melaleuca armillaris EO at different pH. This is interesting in situations where the pH changes are relevant, such as the control of intracellular infections in public health or the development of preservatives for the food industry.
Facultad de Ciencias Veterinarias
Materia
Veterinaria
Staphylococcus aureus
Melaleuca armillaris
essential oil
Gompertz model
Sigmoid model
antibacterial
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/123589
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/123589
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH ConditionsBuldain, Daniel CornelioGortari Castillo, LihuelMarchetti, María LauraJulca Lozano, Karen GeraldineBandoni, Arnaldo L.Mestorino, Olga NoraVeterinariaStaphylococcus aureusMelaleuca armillarisessential oilGompertz modelSigmoid modelantibacterialEssential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models are useful in describing the growth, survival, and inactivation of microorganisms against antimicrobials. We evaluated the antimicrobial activity of <i>Melaleuca armillaris</i> EO obtained from plants placed in the province of Buenos Aires (Argentina) against <i>Staphylococcus aureus</i>. The minimum inhibitory and bactericidal concentrations were close and decreased, slightly acidifying the medium from pH 7.4 to 6.5 and 5.0. This result was also evidenced by applying a sigmoid model, where the time and EO concentration necessaries to achieve 50% of the maximum effect decreased when the medium was acidified. Moreover, at pH 7.4, applying the Gompertz model, we found that subinhibitory concentrations of EO decreased the growth rate and the maximum population density and increased the latency period concerning the control. Additionally, we established physicochemical parameters for quality control and standardization of <i>M. armillaris</i> EO. Mathematical modeling allowed us to estimate key parameters in the behavior of <i>S. aureus</i> and <i>Melaleuca armillaris</i> EO at different pH. This is interesting in situations where the pH changes are relevant, such as the control of intracellular infections in public health or the development of preservatives for the food industry.Facultad de Ciencias Veterinarias2021-02-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/123589enginfo:eu-repo/semantics/altIdentifier/issn/2079-6382info:eu-repo/semantics/altIdentifier/pmid/33672314info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10020222info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:29:28Zoai:sedici.unlp.edu.ar:10915/123589Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:29:28.693SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
title Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
spellingShingle Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
Buldain, Daniel Cornelio
Veterinaria
Staphylococcus aureus
Melaleuca armillaris
essential oil
Gompertz model
Sigmoid model
antibacterial
title_short Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
title_full Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
title_fullStr Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
title_full_unstemmed Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
title_sort Modeling the Growth and Death of <i>Staphylococcus aureus</i> against <i>Melaleuca armillaris</i> Essential Oil at Different pH Conditions
dc.creator.none.fl_str_mv Buldain, Daniel Cornelio
Gortari Castillo, Lihuel
Marchetti, María Laura
Julca Lozano, Karen Geraldine
Bandoni, Arnaldo L.
Mestorino, Olga Nora
author Buldain, Daniel Cornelio
author_facet Buldain, Daniel Cornelio
Gortari Castillo, Lihuel
Marchetti, María Laura
Julca Lozano, Karen Geraldine
Bandoni, Arnaldo L.
Mestorino, Olga Nora
author_role author
author2 Gortari Castillo, Lihuel
Marchetti, María Laura
Julca Lozano, Karen Geraldine
Bandoni, Arnaldo L.
Mestorino, Olga Nora
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Veterinaria
Staphylococcus aureus
Melaleuca armillaris
essential oil
Gompertz model
Sigmoid model
antibacterial
topic Veterinaria
Staphylococcus aureus
Melaleuca armillaris
essential oil
Gompertz model
Sigmoid model
antibacterial
dc.description.none.fl_txt_mv Essential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models are useful in describing the growth, survival, and inactivation of microorganisms against antimicrobials. We evaluated the antimicrobial activity of <i>Melaleuca armillaris</i> EO obtained from plants placed in the province of Buenos Aires (Argentina) against <i>Staphylococcus aureus</i>. The minimum inhibitory and bactericidal concentrations were close and decreased, slightly acidifying the medium from pH 7.4 to 6.5 and 5.0. This result was also evidenced by applying a sigmoid model, where the time and EO concentration necessaries to achieve 50% of the maximum effect decreased when the medium was acidified. Moreover, at pH 7.4, applying the Gompertz model, we found that subinhibitory concentrations of EO decreased the growth rate and the maximum population density and increased the latency period concerning the control. Additionally, we established physicochemical parameters for quality control and standardization of <i>M. armillaris</i> EO. Mathematical modeling allowed us to estimate key parameters in the behavior of <i>S. aureus</i> and <i>Melaleuca armillaris</i> EO at different pH. This is interesting in situations where the pH changes are relevant, such as the control of intracellular infections in public health or the development of preservatives for the food industry.
Facultad de Ciencias Veterinarias
description Essential oils (EO) are a great antimicrobial resource against bacterial resistance in public health. Math models are useful in describing the growth, survival, and inactivation of microorganisms against antimicrobials. We evaluated the antimicrobial activity of <i>Melaleuca armillaris</i> EO obtained from plants placed in the province of Buenos Aires (Argentina) against <i>Staphylococcus aureus</i>. The minimum inhibitory and bactericidal concentrations were close and decreased, slightly acidifying the medium from pH 7.4 to 6.5 and 5.0. This result was also evidenced by applying a sigmoid model, where the time and EO concentration necessaries to achieve 50% of the maximum effect decreased when the medium was acidified. Moreover, at pH 7.4, applying the Gompertz model, we found that subinhibitory concentrations of EO decreased the growth rate and the maximum population density and increased the latency period concerning the control. Additionally, we established physicochemical parameters for quality control and standardization of <i>M. armillaris</i> EO. Mathematical modeling allowed us to estimate key parameters in the behavior of <i>S. aureus</i> and <i>Melaleuca armillaris</i> EO at different pH. This is interesting in situations where the pH changes are relevant, such as the control of intracellular infections in public health or the development of preservatives for the food industry.
publishDate 2021
dc.date.none.fl_str_mv 2021-02-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/123589
url http://sedici.unlp.edu.ar/handle/10915/123589
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2079-6382
info:eu-repo/semantics/altIdentifier/pmid/33672314
info:eu-repo/semantics/altIdentifier/doi/10.3390/antibiotics10020222
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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