Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays

Autores
Suárez, Santiago Emmanuel; Aphalo, Paula; Rinaldi, Gustavo; Añón, María Cristina; Quiroga, Alejandra Viviana
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Facultad de Ciencias Médicas
Materia
Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/151446
Acceder
id SEDICI_4bf8ce5b313f196d50fcf2a36b2c7942
oai_identifier_str oai:sedici.unlp.edu.ar:10915/151446
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assaysSuárez, Santiago EmmanuelAphalo, PaulaRinaldi, GustavoAñón, María CristinaQuiroga, Alejandra VivianaCiencias ExactasAmaranth proteinsAntihypertensive activityProtein hydrolysateSpontaneously hypertensive ratsRenin-angiotensin systemThe aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.Centro de Investigación y Desarrollo en Criotecnología de AlimentosFacultad de Ciencias Médicas2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://sedici.unlp.edu.ar/handle/10915/151446enginfo:eu-repo/semantics/altIdentifier/issn/0308-8146info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodchem.2019.125601info:eu-repo/semantics/reference/hdl/10915/107694info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:30:50Zoai:sedici.unlp.edu.ar:10915/151446Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:30:50.61SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
spellingShingle Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
Suárez, Santiago Emmanuel
Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
title_short Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_full Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_fullStr Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_full_unstemmed Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
title_sort Effect of amaranth proteins on the RAS system : In vitro, in vivo and ex vivo assays
dc.creator.none.fl_str_mv Suárez, Santiago Emmanuel
Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
author Suárez, Santiago Emmanuel
author_facet Suárez, Santiago Emmanuel
Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
author_role author
author2 Aphalo, Paula
Rinaldi, Gustavo
Añón, María Cristina
Quiroga, Alejandra Viviana
author2_role author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
topic Ciencias Exactas
Amaranth proteins
Antihypertensive activity
Protein hydrolysate
Spontaneously hypertensive rats
Renin-angiotensin system
dc.description.none.fl_txt_mv The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Facultad de Ciencias Médicas
description The aim of this work was to analyse the hypotensive effect of amaranth protein/peptides on spontaneously hypertensive rats (SHR). The mechanism of action of these peptides was studied in vivo and ex vivo. We also tested the effect of protection against gastrointestinal digestion (GID) exerted by an O:W emulsion on the integrity of the antihypertensive peptides. All samples tested produced a decrease in blood pressure (SBP). The animals treated with emulsion (GE) and emulsion+peptide (GE+VIKP) showed the most significant reduction in the SBP (42 ± 2 mmHg and 35 ± 2 mmHg, respectively). The results presented suggest that after GID, a variety of peptides with biological activities were released or were resistant to this process. These peptides play a role in the regulation of the SBP by acting on plasma ACE, plasma renin and the vascular system. These results support the use of amaranth protein/peptides in the elaboration of functional foods for hypertensive individuals.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/151446
url http://sedici.unlp.edu.ar/handle/10915/151446
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0308-8146
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodchem.2019.125601
info:eu-repo/semantics/reference/hdl/10915/107694
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.22299

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