Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
- Autores
- Lazarowski, Alberto; Czornyj, Liliana; Girardi, Elena
- Año de publicación
- 2006
- Idioma
- inglés
- Tipo de recurso
- reseña artículo
- Estado
- versión publicada
- Descripción
- Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.
Sociedad Argentina de Fisiología - Materia
-
Ciencias Médicas
Epilepsy
P-glycoprotein - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by/4.0/
- Repositorio
- Institución
- Universidad Nacional de La Plata
- OAI Identificador
- oai:sedici.unlp.edu.ar:10915/147248
Ver los metadatos del registro completo
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Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsyLazarowski, AlbertoCzornyj, LilianaGirardi, ElenaCiencias MédicasEpilepsyP-glycoproteinEpilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.Sociedad Argentina de Fisiología2006-10info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf19-26http://sedici.unlp.edu.ar/handle/10915/147248enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol2_n3_october.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:37:37Zoai:sedici.unlp.edu.ar:10915/147248Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:37:37.599SEDICI (UNLP) - Universidad Nacional de La Platafalse |
dc.title.none.fl_str_mv |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
title |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
spellingShingle |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy Lazarowski, Alberto Ciencias Médicas Epilepsy P-glycoprotein |
title_short |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
title_full |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
title_fullStr |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
title_full_unstemmed |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
title_sort |
Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy |
dc.creator.none.fl_str_mv |
Lazarowski, Alberto Czornyj, Liliana Girardi, Elena |
author |
Lazarowski, Alberto |
author_facet |
Lazarowski, Alberto Czornyj, Liliana Girardi, Elena |
author_role |
author |
author2 |
Czornyj, Liliana Girardi, Elena |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Ciencias Médicas Epilepsy P-glycoprotein |
topic |
Ciencias Médicas Epilepsy P-glycoprotein |
dc.description.none.fl_txt_mv |
Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells. Sociedad Argentina de Fisiología |
description |
Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Revision http://purl.org/coar/resource_type/c_dcae04bc info:ar-repo/semantics/resenaArticulo |
format |
review |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://sedici.unlp.edu.ar/handle/10915/147248 |
url |
http://sedici.unlp.edu.ar/handle/10915/147248 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol2_n3_october.pdf info:eu-repo/semantics/altIdentifier/issn/1669-5410 info:eu-repo/semantics/altIdentifier/issn/1669-5402 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
eu_rights_str_mv |
openAccess |
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http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
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application/pdf 19-26 |
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SEDICI (UNLP) - Universidad Nacional de La Plata |
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alira@sedici.unlp.edu.ar |
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