Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy

Autores
Lazarowski, Alberto; Czornyj, Liliana; Girardi, Elena
Año de publicación
2006
Idioma
inglés
Tipo de recurso
reseña artículo
Estado
versión publicada
Descripción
Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.
Sociedad Argentina de Fisiología
Materia
Ciencias Médicas
Epilepsy
P-glycoprotein
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/147248

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network_name_str SEDICI (UNLP)
spelling Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsyLazarowski, AlbertoCzornyj, LilianaGirardi, ElenaCiencias MédicasEpilepsyP-glycoproteinEpilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.Sociedad Argentina de Fisiología2006-10info:eu-repo/semantics/reviewinfo:eu-repo/semantics/publishedVersionRevisionhttp://purl.org/coar/resource_type/c_dcae04bcinfo:ar-repo/semantics/resenaArticuloapplication/pdf19-26http://sedici.unlp.edu.ar/handle/10915/147248enginfo:eu-repo/semantics/altIdentifier/url/https://pmr.safisiol.org.ar/wp-content/uploads/2022/08/vol2_n3_october.pdfinfo:eu-repo/semantics/altIdentifier/issn/1669-5410info:eu-repo/semantics/altIdentifier/issn/1669-5402info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:37:37Zoai:sedici.unlp.edu.ar:10915/147248Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:37:37.599SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
spellingShingle Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
Lazarowski, Alberto
Ciencias Médicas
Epilepsy
P-glycoprotein
title_short Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_full Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_fullStr Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_full_unstemmed Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
title_sort Clinical and experimental evidences for a role of ABC transporters in the mechanisms underlying multidrug resistance in epilepsy
dc.creator.none.fl_str_mv Lazarowski, Alberto
Czornyj, Liliana
Girardi, Elena
author Lazarowski, Alberto
author_facet Lazarowski, Alberto
Czornyj, Liliana
Girardi, Elena
author_role author
author2 Czornyj, Liliana
Girardi, Elena
author2_role author
author
dc.subject.none.fl_str_mv Ciencias Médicas
Epilepsy
P-glycoprotein
topic Ciencias Médicas
Epilepsy
P-glycoprotein
dc.description.none.fl_txt_mv Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.
Sociedad Argentina de Fisiología
description Epilepsy is a common neurological disorder affecting 1-2% of the general population. Although antiepileptic therapies efficiently control seizures in most patients, it is estimated that 20-25% of the affected population fails to achieve good control with antiepileptic drug (AED) treatment, thus defining refractory epilepsy (RE). Although the underlying mechanisms involved in AED resistance are poorly understood, it has been suggested that unresponsiveness to AEDs resembles the mechanism of resistance to chemotherapy in cancer. Considerable progress has bee attained recently in elucidating the molecular mechanisms of refractoriness during cancer chemotherapy. The foundational finding was that tumor cells become refractory to chemotherapeutic agents due to the action of the P-glycoprotein (P-gp), the product of the MDR-1 gene. P-gp acts as energy-dependent pumps that extrudes potentially toxic compounds out of the cells and can confer resistance levels of 1000-fold or more to the expressing cells.
publishDate 2006
dc.date.none.fl_str_mv 2006-10
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dc.language.none.fl_str_mv eng
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info:eu-repo/semantics/altIdentifier/issn/1669-5410
info:eu-repo/semantics/altIdentifier/issn/1669-5402
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
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Creative Commons Attribution 4.0 International (CC BY 4.0)
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