Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress

Autores
Mónaco, Nina; Bartos, Mariana; Dominguez, Sergio; Gallegos, Cristina Eugenia; Bras, Cristina; del Carmen Esandi, María; Bouzat, Cecilia; Giannuzzi, Leda; Minetti, Alejandra; Gumilar, Fernanda
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
Materia
Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/131976
Acceder
id SEDICI_446dcea71cef63af7136d23238d44862
oai_identifier_str oai:sedici.unlp.edu.ar:10915/131976
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stressMónaco, NinaBartos, MarianaDominguez, SergioGallegos, Cristina EugeniaBras, Cristinadel Carmen Esandi, MaríaBouzat, CeciliaGiannuzzi, LedaMinetti, AlejandraGumilar, FernandaCiencias ExactasQuímicaArsenic α7-nicotinic receptorOxidative stressGlutamatesFemale ratsInorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.Centro de Investigación y Desarrollo en Criotecnología de Alimentos2018-04-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf37-45http://sedici.unlp.edu.ar/handle/10915/131976enginfo:eu-repo/semantics/altIdentifier/issn/1872-9711info:eu-repo/semantics/altIdentifier/issn/0161-813xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2018.04.011info:eu-repo/semantics/altIdentifier/pmid/29678590info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2026-05-27T11:25:55Zoai:sedici.unlp.edu.ar:10915/131976Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292026-05-27 11:25:55.909SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
spellingShingle Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
Mónaco, Nina
Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
title_short Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_full Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_fullStr Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_full_unstemmed Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
title_sort Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation : Role of α7 nicotinic receptor, glutamate and oxidative stress
dc.creator.none.fl_str_mv Mónaco, Nina
Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
author Mónaco, Nina
author_facet Mónaco, Nina
Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
author_role author
author2 Bartos, Mariana
Dominguez, Sergio
Gallegos, Cristina Eugenia
Bras, Cristina
del Carmen Esandi, María
Bouzat, Cecilia
Giannuzzi, Leda
Minetti, Alejandra
Gumilar, Fernanda
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
topic Ciencias Exactas
Química
Arsenic α7-nicotinic receptor
Oxidative stress
Glutamates
Female rats
dc.description.none.fl_txt_mv Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.
Centro de Investigación y Desarrollo en Criotecnología de Alimentos
description Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.
publishDate 2018
dc.date.none.fl_str_mv 2018-04-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/131976
url http://sedici.unlp.edu.ar/handle/10915/131976
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1872-9711
info:eu-repo/semantics/altIdentifier/issn/0161-813x
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuro.2018.04.011
info:eu-repo/semantics/altIdentifier/pmid/29678590
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
37-45
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 12.98848

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