Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states

Autores
Gonzalez, M. Micaela; Denofrio, María Paula; García Einschlag, Fernando Sebastián; Franca, Carlos Alberto; Pis Diez, Reinaldo; Erra-Balsells, Rosa; Cabrerizo, Franco Martín
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.
Centro de Química Inorgánica
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Materia
Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/3.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/151512
Acceder
id SEDICI_38ef85a3a17999dea1d5948bfc596ae1
oai_identifier_str oai:sedici.unlp.edu.ar:10915/151512
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited statesGonzalez, M. MicaelaDenofrio, María PaulaGarcía Einschlag, Fernando SebastiánFranca, Carlos AlbertoPis Diez, ReinaldoErra-Balsells, RosaCabrerizo, Franco MartínQuímicaFísicaBeta-CarbolinesAlkaloidsNitrogen HeterocyclesNucleotidesSelf AssembyHeteroassociatonChemometricsInteraction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.Centro de Química InorgánicaInstituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf16547-16562http://sedici.unlp.edu.ar/handle/10915/151512enginfo:eu-repo/semantics/altIdentifier/issn/1463-9076info:eu-repo/semantics/altIdentifier/issn/1463-9084info:eu-repo/semantics/altIdentifier/doi/10.1039/C4CP01910Einfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/Creative Commons Attribution 3.0 Unported (CC BY 3.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:39:02Zoai:sedici.unlp.edu.ar:10915/151512Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:39:02.659SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
spellingShingle Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
Gonzalez, M. Micaela
Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
title_short Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_fullStr Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_full_unstemmed Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
title_sort Determining the molecular basis for the pH-dependent interaction between 2′-deoxynucleotides and 9H-pyrido[3,4-b]indole in its ground and electronic excited states
dc.creator.none.fl_str_mv Gonzalez, M. Micaela
Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
author Gonzalez, M. Micaela
author_facet Gonzalez, M. Micaela
Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
author_role author
author2 Denofrio, María Paula
García Einschlag, Fernando Sebastián
Franca, Carlos Alberto
Pis Diez, Reinaldo
Erra-Balsells, Rosa
Cabrerizo, Franco Martín
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
topic Química
Física
Beta-Carbolines
Alkaloids
Nitrogen Heterocycles
Nucleotides
Self Assemby
Heteroassociaton
Chemometrics
dc.description.none.fl_txt_mv Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.
Centro de Química Inorgánica
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
description Interaction between norharmane and three different 2′-deoxynucleotides (dNMP) (2′-deoxyguanosine 5′-monophosphate (dGMP), 2′-deoxyadenosine 5′-monophosphate (dAMP) and 2′-deoxycytidine 5′-monophosphate (dCMP)), in aqueous solution, was studied in the ground state by means of UV-vis and ¹H-NMR spectroscopy and in the first electronic excited state using steady-state and time-resolved fluorescence spectroscopy. In all cases, the norharmane–dNMP interaction dependence on the pH was examined. Possible mechanisms for the interaction of both ground and electronic excited states of norharmane with nucleotides are discussed. Spectroscopic, molecular modeling and chemometric analysis were performed to further characterize the chemical structure of the complexes formed and to get additional information concerning the interaction between dNMPs and norharmane.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/151512
url http://sedici.unlp.edu.ar/handle/10915/151512
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/1463-9076
info:eu-repo/semantics/altIdentifier/issn/1463-9084
info:eu-repo/semantics/altIdentifier/doi/10.1039/C4CP01910E
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/
Creative Commons Attribution 3.0 Unported (CC BY 3.0)
dc.format.none.fl_str_mv application/pdf
16547-16562
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.070432

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