First report of cerebellar abiotrophy in an Arabian foal from Argentina

Autores
Sadaba, Sebastián Andres; Madariaga, G.J; Corbi Botto, Claudia; Carino, Mónica H.; Zappa, María Eugenia; Peral García, Pilar; Olguín, Silvia Andrea; Massone, Adriana Raquel; Díaz, Silvina
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.
Instituto de Genética Veterinaria
Facultad de Ciencias Veterinarias
Materia
Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/85963
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/85963
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling First report of cerebellar abiotrophy in an Arabian foal from ArgentinaSadaba, Sebastián AndresMadariaga, G.JCorbi Botto, ClaudiaCarino, Mónica H.Zappa, María EugeniaPeral García, PilarOlguín, Silvia AndreaMassone, Adriana RaquelDíaz, SilvinaCiencias VeterinariasApoptosisArabian horsesCerebellar abiotrophyDNAPurkinje cellsEvidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.Instituto de Genética VeterinariaFacultad de Ciencias Veterinarias2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf259-262http://sedici.unlp.edu.ar/handle/10915/85963enginfo:eu-repo/semantics/altIdentifier/issn/2226-4485info:eu-repo/semantics/altIdentifier/doi/10.4314/ovj.v6i3.17info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:48:58Zoai:sedici.unlp.edu.ar:10915/85963Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:48:59.222SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv First report of cerebellar abiotrophy in an Arabian foal from Argentina
title First report of cerebellar abiotrophy in an Arabian foal from Argentina
spellingShingle First report of cerebellar abiotrophy in an Arabian foal from Argentina
Sadaba, Sebastián Andres
Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
title_short First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_full First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_fullStr First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_full_unstemmed First report of cerebellar abiotrophy in an Arabian foal from Argentina
title_sort First report of cerebellar abiotrophy in an Arabian foal from Argentina
dc.creator.none.fl_str_mv Sadaba, Sebastián Andres
Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
author Sadaba, Sebastián Andres
author_facet Sadaba, Sebastián Andres
Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
author_role author
author2 Madariaga, G.J
Corbi Botto, Claudia
Carino, Mónica H.
Zappa, María Eugenia
Peral García, Pilar
Olguín, Silvia Andrea
Massone, Adriana Raquel
Díaz, Silvina
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
topic Ciencias Veterinarias
Apoptosis
Arabian horses
Cerebellar abiotrophy
DNA
Purkinje cells
dc.description.none.fl_txt_mv Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.
Instituto de Genética Veterinaria
Facultad de Ciencias Veterinarias
description Evidence of cerebellar abiotrophy (CA) was found in a six-month-old Arabian filly with signs of incoordination, head tremor, wobbling, loss of balance and falling over, consistent with a cerebellar lesion. Normal hematology profile blood test and cerebrospinal fluid analysis excluded infectious encephalitis, and serological testing for Sarcocystis neurona was negative. The filly was euthanized. Postmortem X-ray radiography of the cervical cephalic region identified not abnormalities, discounting spinal trauma. The histopathological analysis of serial transverse cerebellar sections by electron microscopy revealed morphological characteristics of apoptotic cells with pyknotic nuclei and degenerate mitochondria, cytoplasmic condensation and areas with absence of Purkinje cells, matching with CA histopathological characteristics. The indirect DNA test for CA was positive in the filly, and DNA test confirmed the CA carrier state in the parents and the recessive inheritance of the disease. To our knowledge this is the first report of a CA case in Argentina.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/85963
url http://sedici.unlp.edu.ar/handle/10915/85963
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/2226-4485
info:eu-repo/semantics/altIdentifier/doi/10.4314/ovj.v6i3.17
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
259-262
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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