Photosensitization of peptides and proteins by pterin derivatives

Autores
Dántola, María Laura; Reid, Lara Olivia; Castaño, Carolina; Lorente, Carolina; Oliveros, Esther; Thomas, Andrés Héctor
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological conditions, such as vitiligo, oxidized pterins accumulate in the white skin patches of patients suffering this depigmentation disorder. It is known that pterins are able to photosensitize damage in nucleotides and DNA by type I (electron transfer) and type II (singlet oxygen) mechanisms. Recently, it has been demonstrated that proteins and its components may also be damaged when solutions containing both proteins and pterin are exposed to UV-A radiation. Therefore, given the biological and medical relevance of the photosensitizing properties of these molecules, we present in this article an overview of the capability of different pterin derivatives to photoinduce damage in proteins present in the skin, focusing our attention on the chemical modifications of tyrosine and tryptophan residues.
Facultad de Ciencias Exactas
Materia
Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/74893
Acceder
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oai_identifier_str oai:sedici.unlp.edu.ar:10915/74893
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Photosensitization of peptides and proteins by pterin derivativesDántola, María LauraReid, Lara OliviaCastaño, CarolinaLorente, CarolinaOliveros, EstherThomas, Andrés HéctorCiencias ExactasQuímicaPteridinaselectron transfer; photosensitization; proteins; pterins; UV-A radiationProteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological conditions, such as vitiligo, oxidized pterins accumulate in the white skin patches of patients suffering this depigmentation disorder. It is known that pterins are able to photosensitize damage in nucleotides and DNA by type I (electron transfer) and type II (singlet oxygen) mechanisms. Recently, it has been demonstrated that proteins and its components may also be damaged when solutions containing both proteins and pterin are exposed to UV-A radiation. Therefore, given the biological and medical relevance of the photosensitizing properties of these molecules, we present in this article an overview of the capability of different pterin derivatives to photoinduce damage in proteins present in the skin, focusing our attention on the chemical modifications of tyrosine and tryptophan residues.Facultad de Ciencias Exactas2017-10-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf105-114http://sedici.unlp.edu.ar/handle/10915/74893enginfo:eu-repo/semantics/altIdentifier/doi/10.1515/pterid-2017-0013info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-03T10:45:00Zoai:sedici.unlp.edu.ar:10915/74893Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-03 10:45:00.876SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Photosensitization of peptides and proteins by pterin derivatives
title Photosensitization of peptides and proteins by pterin derivatives
spellingShingle Photosensitization of peptides and proteins by pterin derivatives
Dántola, María Laura
Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
title_short Photosensitization of peptides and proteins by pterin derivatives
title_full Photosensitization of peptides and proteins by pterin derivatives
title_fullStr Photosensitization of peptides and proteins by pterin derivatives
title_full_unstemmed Photosensitization of peptides and proteins by pterin derivatives
title_sort Photosensitization of peptides and proteins by pterin derivatives
dc.creator.none.fl_str_mv Dántola, María Laura
Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
author Dántola, María Laura
author_facet Dántola, María Laura
Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
author_role author
author2 Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
topic Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
dc.description.none.fl_txt_mv Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological conditions, such as vitiligo, oxidized pterins accumulate in the white skin patches of patients suffering this depigmentation disorder. It is known that pterins are able to photosensitize damage in nucleotides and DNA by type I (electron transfer) and type II (singlet oxygen) mechanisms. Recently, it has been demonstrated that proteins and its components may also be damaged when solutions containing both proteins and pterin are exposed to UV-A radiation. Therefore, given the biological and medical relevance of the photosensitizing properties of these molecules, we present in this article an overview of the capability of different pterin derivatives to photoinduce damage in proteins present in the skin, focusing our attention on the chemical modifications of tyrosine and tryptophan residues.
Facultad de Ciencias Exactas
description Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological conditions, such as vitiligo, oxidized pterins accumulate in the white skin patches of patients suffering this depigmentation disorder. It is known that pterins are able to photosensitize damage in nucleotides and DNA by type I (electron transfer) and type II (singlet oxygen) mechanisms. Recently, it has been demonstrated that proteins and its components may also be damaged when solutions containing both proteins and pterin are exposed to UV-A radiation. Therefore, given the biological and medical relevance of the photosensitizing properties of these molecules, we present in this article an overview of the capability of different pterin derivatives to photoinduce damage in proteins present in the skin, focusing our attention on the chemical modifications of tyrosine and tryptophan residues.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-17
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/74893
url http://sedici.unlp.edu.ar/handle/10915/74893
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/pterid-2017-0013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
105-114
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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score 13.13397

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