Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>

Autores
Buckley, Michael; Fariña, Richard A.; Lawless, Craig; Tambusso, P. Sebastián; Varela, Luciano; Carlini, Alfredo Armando; Powell, Jaime Eduardo; Martínez, Jorge Gabriel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
For over 200 years, fossils of bizarre extinct creatures have been described from the Americas that have ranged from giant ground sloths to the 'native' South American ungulates, groups of mammals that evolved in relative isolation on South America. Ground sloths belong to the South American xenarthrans, a group with modern although morphologically and ecologically very different representatives (anteaters, armadillos and sloths), which has been proposed to be one of the four main eutherian clades. Recently, proteomics analyses of bone collagen have recently been used to yield a molecular phylogeny for a range of mammals including the unusual 'Malagasy aardvark' shown to be most closely related to the afrotherian tenrecs, and the south American ungulates supporting their morphological association with condylarths. However, proteomics results generate partial sequence information that could impact upon the phylogenetic placement that has not been appropriately tested. For comparison, this paper examines the phylogenetic potential of proteomicsbased sequencing through the analysis of collagen extracted from two extinct giant ground sloths, Lestodon and Megatherium. The ground sloths were placed as sister taxa to extant sloths, but with a closer relationship between Lestodon and the extant sloths than the basal Megatherium. These results highlight that proteomics methods could yield plausible phylogenies that share similarities with other methods, but have the potential to be more useful in fossils beyond the limits of ancient DNA survival.
Facultad de Ciencias Naturales y Museo
Materia
Ciencias Naturales
Colágeno
Proteómica
Megafauna pleistocénica
Antofagasta de la sierra
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/99921

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spelling Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>Buckley, MichaelFariña, Richard A.Lawless, CraigTambusso, P. SebastiánVarela, LucianoCarlini, Alfredo ArmandoPowell, Jaime EduardoMartínez, Jorge GabrielCiencias NaturalesColágenoProteómicaMegafauna pleistocénicaAntofagasta de la sierraFor over 200 years, fossils of bizarre extinct creatures have been described from the Americas that have ranged from giant ground sloths to the 'native' South American ungulates, groups of mammals that evolved in relative isolation on South America. Ground sloths belong to the South American xenarthrans, a group with modern although morphologically and ecologically very different representatives (anteaters, armadillos and sloths), which has been proposed to be one of the four main eutherian clades. Recently, proteomics analyses of bone collagen have recently been used to yield a molecular phylogeny for a range of mammals including the unusual 'Malagasy aardvark' shown to be most closely related to the afrotherian tenrecs, and the south American ungulates supporting their morphological association with condylarths. However, proteomics results generate partial sequence information that could impact upon the phylogenetic placement that has not been appropriately tested. For comparison, this paper examines the phylogenetic potential of proteomicsbased sequencing through the analysis of collagen extracted from two extinct giant ground sloths, <i>Lestodon</i> and <i>Megatherium</i>. The ground sloths were placed as sister taxa to extant sloths, but with a closer relationship between <i>Lestodon</i> and the extant sloths than the basal <i>Megatherium</i>. These results highlight that proteomics methods could yield plausible phylogenies that share similarities with other methods, but have the potential to be more useful in fossils beyond the limits of ancient DNA survival.Facultad de Ciencias Naturales y Museo2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1-11http://sedici.unlp.edu.ar/handle/10915/99921enginfo:eu-repo/semantics/altIdentifier/url/https://ri.conicet.gov.ar/11336/51264info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0139611info:eu-repo/semantics/altIdentifier/issn/1932-6203info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0139611info:eu-repo/semantics/altIdentifier/hdl/11336/51264info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-09-29T11:20:06Zoai:sedici.unlp.edu.ar:10915/99921Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-09-29 11:20:06.978SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
title Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
spellingShingle Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
Buckley, Michael
Ciencias Naturales
Colágeno
Proteómica
Megafauna pleistocénica
Antofagasta de la sierra
title_short Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
title_full Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
title_fullStr Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
title_full_unstemmed Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
title_sort Collagen sequence analysis of the extinct giant ground sloths <i>Lestodon</i> and <i>Megatherium</i>
dc.creator.none.fl_str_mv Buckley, Michael
Fariña, Richard A.
Lawless, Craig
Tambusso, P. Sebastián
Varela, Luciano
Carlini, Alfredo Armando
Powell, Jaime Eduardo
Martínez, Jorge Gabriel
author Buckley, Michael
author_facet Buckley, Michael
Fariña, Richard A.
Lawless, Craig
Tambusso, P. Sebastián
Varela, Luciano
Carlini, Alfredo Armando
Powell, Jaime Eduardo
Martínez, Jorge Gabriel
author_role author
author2 Fariña, Richard A.
Lawless, Craig
Tambusso, P. Sebastián
Varela, Luciano
Carlini, Alfredo Armando
Powell, Jaime Eduardo
Martínez, Jorge Gabriel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ciencias Naturales
Colágeno
Proteómica
Megafauna pleistocénica
Antofagasta de la sierra
topic Ciencias Naturales
Colágeno
Proteómica
Megafauna pleistocénica
Antofagasta de la sierra
dc.description.none.fl_txt_mv For over 200 years, fossils of bizarre extinct creatures have been described from the Americas that have ranged from giant ground sloths to the 'native' South American ungulates, groups of mammals that evolved in relative isolation on South America. Ground sloths belong to the South American xenarthrans, a group with modern although morphologically and ecologically very different representatives (anteaters, armadillos and sloths), which has been proposed to be one of the four main eutherian clades. Recently, proteomics analyses of bone collagen have recently been used to yield a molecular phylogeny for a range of mammals including the unusual 'Malagasy aardvark' shown to be most closely related to the afrotherian tenrecs, and the south American ungulates supporting their morphological association with condylarths. However, proteomics results generate partial sequence information that could impact upon the phylogenetic placement that has not been appropriately tested. For comparison, this paper examines the phylogenetic potential of proteomicsbased sequencing through the analysis of collagen extracted from two extinct giant ground sloths, <i>Lestodon</i> and <i>Megatherium</i>. The ground sloths were placed as sister taxa to extant sloths, but with a closer relationship between <i>Lestodon</i> and the extant sloths than the basal <i>Megatherium</i>. These results highlight that proteomics methods could yield plausible phylogenies that share similarities with other methods, but have the potential to be more useful in fossils beyond the limits of ancient DNA survival.
Facultad de Ciencias Naturales y Museo
description For over 200 years, fossils of bizarre extinct creatures have been described from the Americas that have ranged from giant ground sloths to the 'native' South American ungulates, groups of mammals that evolved in relative isolation on South America. Ground sloths belong to the South American xenarthrans, a group with modern although morphologically and ecologically very different representatives (anteaters, armadillos and sloths), which has been proposed to be one of the four main eutherian clades. Recently, proteomics analyses of bone collagen have recently been used to yield a molecular phylogeny for a range of mammals including the unusual 'Malagasy aardvark' shown to be most closely related to the afrotherian tenrecs, and the south American ungulates supporting their morphological association with condylarths. However, proteomics results generate partial sequence information that could impact upon the phylogenetic placement that has not been appropriately tested. For comparison, this paper examines the phylogenetic potential of proteomicsbased sequencing through the analysis of collagen extracted from two extinct giant ground sloths, <i>Lestodon</i> and <i>Megatherium</i>. The ground sloths were placed as sister taxa to extant sloths, but with a closer relationship between <i>Lestodon</i> and the extant sloths than the basal <i>Megatherium</i>. These results highlight that proteomics methods could yield plausible phylogenies that share similarities with other methods, but have the potential to be more useful in fossils beyond the limits of ancient DNA survival.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
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