Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering

Autores
Lastra, María Laura; Molinuevo, María Silvina; Cortizo, Ana María; Cortizo, María Susana
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Laboratorio de Investigación en Osteopatías y Metabolismo Mineral
Materia
Física
Química
Cross-linked polymers
Osteochondrogenic tissue
Nivel de accesibilidad
acceso abierto
Condiciones de uso
http://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
SEDICI (UNLP)
Institución
Universidad Nacional de La Plata
OAI Identificador
oai:sedici.unlp.edu.ar:10915/103339
Acceder
id SEDICI_25fad2861442a8bea86315e344412f5a
oai_identifier_str oai:sedici.unlp.edu.ar:10915/103339
network_acronym_str SEDICI
repository_id_str 1329
network_name_str SEDICI (UNLP)
spelling Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue EngineeringLastra, María LauraMolinuevo, María SilvinaCortizo, Ana MaríaCortizo, María SusanaFísicaQuímicaCross-linked polymersOsteochondrogenic tissueNatural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.Instituto de Investigaciones Fisicoquímicas Teóricas y AplicadasLaboratorio de Investigación en Osteopatías y Metabolismo Mineral2016-11-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf1600219-1600219http://sedici.unlp.edu.ar/handle/10915/103339enginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201600219info:eu-repo/semantics/altIdentifier/issn/1616-5187info:eu-repo/semantics/altIdentifier/doi/10.1002/mabi.201600219info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2025-10-15T11:14:20Zoai:sedici.unlp.edu.ar:10915/103339Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292025-10-15 11:14:20.655SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
spellingShingle Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
Lastra, María Laura
Física
Química
Cross-linked polymers
Osteochondrogenic tissue
title_short Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_full Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_fullStr Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_full_unstemmed Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
title_sort Fumarate Copolymer–Chitosan Cross-Linked Scaffold Directed to Osteochondrogenic Tissue Engineering
dc.creator.none.fl_str_mv Lastra, María Laura
Molinuevo, María Silvina
Cortizo, Ana María
Cortizo, María Susana
author Lastra, María Laura
author_facet Lastra, María Laura
Molinuevo, María Silvina
Cortizo, Ana María
Cortizo, María Susana
author_role author
author2 Molinuevo, María Silvina
Cortizo, Ana María
Cortizo, María Susana
author2_role author
author
author
dc.subject.none.fl_str_mv Física
Química
Cross-linked polymers
Osteochondrogenic tissue
topic Física
Química
Cross-linked polymers
Osteochondrogenic tissue
dc.description.none.fl_txt_mv Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Laboratorio de Investigación en Osteopatías y Metabolismo Mineral
description Natural and synthetic cross-linked polymers allow the improvement of cytocompatibility and mechanical properties of the individual polymers. In osteochondral lesions of big size it will be required the use of scaffolds to repair the lesion. In this work a borax cross-linked scaffold based on fumarate-vinyl acetate copolymer and chitosan directed to osteochondrondral tissue engineering is developed. The cross-linked scaffolds and physical blends of the polymers are analyzed in based on their morphology, glass transition temperature, and mechanical properties. In addition, the stability, degradation behavior, and the swelling kinetics are studied. The results demonstrate that the borax cross-linked scaffold exhibits hydrogel behavior with appropriated mechanical properties for bone and cartilage tissue regeneration. Bone marrow progenitor cells and primary chondrocytes are used to demonstrate its osteo- and chondrogenic properties, respectively, assessing the osteoand chondroblastic growth and maturation, without evident signs of cytotoxicity as it is evaluated in an in vitro system.
publishDate 2016
dc.date.none.fl_str_mv 2016-11-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/103339
url http://sedici.unlp.edu.ar/handle/10915/103339
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/mabi.201600219
info:eu-repo/semantics/altIdentifier/issn/1616-5187
info:eu-repo/semantics/altIdentifier/doi/10.1002/mabi.201600219
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
dc.format.none.fl_str_mv application/pdf
1600219-1600219
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
_version_ 1846064201249849344
score 13.22299

Publicaciones similares